| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 37, 26127-26134, September 10, 1999
1 Is Activated by Capacitative Calcium
Entry That Follows Phospholipase C-
Activation upon Bradykinin
Stimulation
,,,,, and
From the To characterize the regulatory mechanism of
phospholipase C- Department of Life Science, Pohang
University of Science and Technology, Pohang, 790-784, Republic of
Korea and the § Department of Biochemistry, College of
Medicine, Chung-Ang University, Seoul,
156-756, Republic of Korea
1 (PLC-1) in the bradykinin (BK)
receptor-mediated signaling pathway, we used a clone of PC12 cells,
which stably overexpress PLC-1 (PC12-D1). Stimulation with BK
induced a significantly higher Ca2+ elevation and
inositol 1,4,5-trisphosphate (IP3) production with a much
lower half-maximal effective concentration (EC50) of BK in
PC12-D1 cells than in wild type (PC12-W) or vector-transfected (PC12-V)
cells. However, BK-induced intracellular Ca2+ release and
IP3 generation was similar between PC12-V and PC12-D1 cells
in the absence of extracellular Ca2+, suggesting that the
availability of extracellular Ca2+ is essential to the
activation of PLC-1. When PC12-D1 cells were treated with agents
that induce Ca2+ influx, more IP3 was produced,
suggesting that the Ca2+ entry induces IP3
production in PC12-D1 cells. Furthermore, the additional
IP3 production after BK-induced capacitative calcium entry
was detected in PC12-D1 cells, suggesting that PLC-1 is mainly
activated by capacitative calcium entry. When cells were stimulated
with BK in the presence of extracellular Ca2+,
[3H]norepinephrine secretion was much greater from
PC12-D1 cells than from PC12-V cells. Our results suggest that PLC-1
is activated by capacitative calcium entry following the activation of
PLC-
, additively inducing IP3 production and
Ca2+ rise in BK-stimulated PC12 cells.
This article has been cited by other articles:
|
|
 |
|
  Y. Naito, M. Okada, and H. Yagisawa Phospholipase C Isoforms Are Localized at the Cleavage Furrow during Cytokinesis J. Biochem., December 1, 2006; 140(6): 785 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-S. Park, E.-M. Hur, B.-H. Choi, E. Kwak, D.-J. Jun, S.-J. Park, and K.-T. Kim Involvement of Protein Kinase C-{varepsilon} in Activity-Dependent Potentiation of Large Dense-Core Vesicle Exocytosis in Chromaffin Cells. J. Neurosci., August 30, 2006; 26(35): 8999 - 9005. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. Kelley, K. A. Kaproth-Joslin, S. E. Reks, A. V. Smrcka, and R. J. H. Wojcikiewicz G-protein-coupled Receptor Agonists Activate Endogenous Phospholipase C{epsilon} and Phospholipase Cbeta3 in a Temporally Distinct Manner J. Biol. Chem., February 3, 2006; 281(5): 2639 - 2648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Thore, O. Dyachok, E. Gylfe, and A. Tengholm Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca2+ in insulin-secreting {beta}-cells J. Cell Sci., October 1, 2005; 118(19): 4463 - 4471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. F. Horowitz, W. Hirdes, B.-C. Suh, D. W. Hilgemann, K. Mackie, and B. Hille Phospholipase C in Living Cells: Activation, Inhibition, Ca2+ Requirement, and Regulation of M Current J. Gen. Physiol., August 29, 2005; 126(3): 243 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nakahara, M. Shimozawa, Y. Nakamura, Y. Irino, M. Morita, Y. Kudo, and K. Fukami A Novel Phospholipase C, PLC{eta}2, Is a Neuron-specific Isozyme J. Biol. Chem., August 12, 2005; 280(32): 29128 - 29134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Sidhu, R. R. Clough, and R. P. Bhullar Regulation of Phospholipase C-{delta}1 through Direct Interactions with the Small GTPase Ral and Calmodulin J. Biol. Chem., June 10, 2005; 280(23): 21933 - 21941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Stallings, E. G. Tall, S. Pentyala, and M. J. Rebecchi Nuclear Translocation of Phospholipase C-{delta}1 Is Linked to the Cell Cycle and Nuclear Phosphatidylinositol 4,5-Bisphosphate J. Biol. Chem., June 10, 2005; 280(23): 22060 - 22069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.-M. Hur, Y.-S. Park, Y. H. Huh, S. H. Yoo, K.-C. Woo, B.-H. Choi, and K.-T. Kim Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling J. Cell Biol., May 23, 2005; 169(4): 657 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Parekh and J. W. Putney Jr. Store-Operated Calcium Channels Physiol Rev, April 1, 2005; 85(2): 757 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Guo, M. Rebecchi, and S. Scarlata Phospholipase C{beta}2 Binds to and Inhibits Phospholipase C{delta}1 J. Biol. Chem., January 14, 2005; 280(2): 1438 - 1447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Murthy, H. Zhou, J. Huang, and S. N. Pentyala Activation of PLC-{delta}1 by Gi/o-coupled receptor agonists Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1679 - C1687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Seifert, M. R. Wing, J. T. Snyder, S. Gershburg, J. Sondek, and T. K. Harden RhoA Activates Purified Phospholipase C-{epsilon} by a Guanine Nucleotide-dependent Mechanism J. Biol. Chem., November 12, 2004; 279(46): 47992 - 47997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Spruce, L. A. Campbell, N. McTavish, M. A. Cooper, M. V. L. Appleyard, M. O'Neill, J. Howie, J. Samson, S. Watt, K. Murray, et al. Small Molecule Antagonists of the {sigma}-1 Receptor Cause Selective Release of the Death Program in Tumor and Self-Reliant Cells and Inhibit Tumor Growth in Vitro and in Vivo Cancer Res., July 15, 2004; 64(14): 4875 - 4886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Stope, F. vom Dorp, D. Szatkowski, A. Bohm, M. Keiper, J. Nolte, P. A. Oude Weernink, D. Rosskopf, S. Evellin, K. H. Jakobs, et al. Rap2B-Dependent Stimulation of Phospholipase C-{varepsilon} by Epidermal Growth Factor Receptor Mediated by c-Src Phosphorylation of RasGRP3 Mol. Cell. Biol., June 1, 2004; 24(11): 4664 - 4676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.-M. Hur, Y.-S. Park, B. D. Lee, I. H. Jang, H. S. Kim, T.-D. Kim, P.-G. Suh, S. H. Ryu, and K.-T. Kim Sensitization of Epidermal Growth Factor-induced Signaling by Bradykinin Is Mediated by c-Src: IMPLICATIONS FOR A ROLE OF LIPID MICRODOMAINS J. Biol. Chem., February 13, 2004; 279(7): 5852 - 5860. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Carraway, X. Gui, and D. E. Cochrane Ca2+ Channel Blockers Enhance Neurotensin (NT) Binding and Inhibit NT-Induced Inositol Phosphate Formation in Prostate Cancer PC3 Cells J. Pharmacol. Exp. Ther., November 1, 2003; 307(2): 640 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Wing, J. T. Snyder, J. Sondek, and T. K. Harden Direct Activation of Phospholipase C-{epsilon} by Rho J. Biol. Chem., October 17, 2003; 278(42): 41253 - 41258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-S. Bae, T. G. Lee, J. C. Park, J. H. Hur, Y. Kim, K. Heo, J.-Y. Kwak, P.-G. Suh, and S. H. Ryu Identification of a Compound That Directly Stimulates Phospholipase C Activity Mol. Pharmacol., May 1, 2003; 63(5): 1043 - 1050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rajebhosale, S. Greenwood, J. Vidugiriene, A. Jeromin, and S. Hilfiker Phosphatidylinositol 4-OH Kinase Is a Downstream Target of Neuronal Calcium Sensor-1 in Enhancing Exocytosis in Neuroendocrine Cells J. Biol. Chem., February 14, 2003; 278(8): 6075 - 6084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sakurada, H. Kato, H. Nagumo, H. Hiraoka, K. Furuya, T. Ikuhara, Y. Yamakita, K. Fukunaga, E. Miyamoto, F. Matsumura, et al. Synapsin I Is Phosphorylated at Ser603 by p21-activated Kinases (PAKs) in Vitro and in PC12 Cells Stimulated with Bradykinin J. Biol. Chem., November 15, 2002; 277(47): 45473 - 45479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Koizumi, P. Rosa, G. B. Willars, R. A. J. Challiss, E. Taverna, M. Francolini, M. D. Bootman, P. Lipp, K. Inoue, J. Roder, et al. Mechanisms Underlying the Neuronal Calcium Sensor-1-evoked Enhancement of Exocytosis in PC12 Cells J. Biol. Chem., August 9, 2002; 277(33): 30315 - 30324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Evellin, J. Nolte, K. Tysack, F. vom Dorp, M. Thiel, P. A. O. Weernink, K. H. Jakobs, E. J. Webb, J. W. Lomasney, and M. Schmidt Stimulation of Phospholipase C-epsilon by the M3 Muscarinic Acetylcholine Receptor Mediated by Cyclic AMP and the GTPase Rap2B J. Biol. Chem., May 3, 2002; 277(19): 16805 - 16813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Wing, D. Houston, G. G. Kelley, C. J. Der, D. P. Siderovski, and T. K. Harden Activation of Phospholipase C-epsilon by Heterotrimeric G Protein beta gamma -Subunits J. Biol. Chem., December 14, 2001; 276(51): 48257 - 48261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. MacKenzie, E. M. Lutz, M. S. Johnson, D. N. Robertson, P. J. Holland, and R. Mitchell Mechanisms of Phospholipase C Activation by the Vasoactive Intestinal Polypeptide/Pituitary Adenylate Cyclase-Activating Polypeptide Type 2 Receptor Endocrinology, March 1, 2001; 142(3): 1209 - 1217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Rebecchi and S. N. Pentyala Structure, Function, and Control of Phosphoinositide-Specific Phospholipase C Physiol Rev, October 1, 2000; 80(4): 1291 - 1335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Nash, R. Saunders, K. W. Young, R. A. J. Challiss, and S. R. Nahorski Reassessment of the Ca2+ Sensing Property of a Type I Metabotropic Glutamate Receptor by Simultaneous Measurement of Inositol 1,4,5-Trisphosphate and Ca2+ in Single Cells J. Biol. Chem., May 25, 2001; 276(22): 19286 - 19293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Lopez, E. C. Mak, J. Ding, H. E. Hamm, and J. W. Lomasney A Novel Bifunctional Phospholipase C That Is Regulated by Galpha 12 and Stimulates the Ras/Mitogen-activated Protein Kinase Pathway J. Biol. Chem., January 19, 2001; 276(4): 2758 - 2765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Baek, S. K. Kang, D. S. Damron, and M.-J. Im Phospholipase Cdelta 1 Is a Guanine Nucleotide Exchanging Factor for Transglutaminase II (Galpha h) and Promotes alpha 1B-Adrenoreceptor-mediated GTP Binding and Intracellular Calcium Release J. Biol. Chem., February 16, 2001; 276(8): 5591 - 5597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Glazner, S. Camandola, J. D. Geiger, and M. P. Mattson Endoplasmic Reticulum D-myo-Inositol 1,4,5-Trisphosphate-sensitive Stores Regulate Nuclear Factor-kappa B Binding Activity in a Calcium-independent Manner J. Biol. Chem., June 15, 2001; 276(25): 22461 - 22467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Mitchell, M. M. Kelly, M. Blewitt, J. R. Wilson, and T. J. Biden Phospholipase C-gamma Mediates the Hydrolysis of Phosphatidylinositol, but Not of Phosphatidylinositol 4,5-Bisphoshate, in Carbamylcholine-stimulated Islets of Langerhans J. Biol. Chem., May 25, 2001; 276(22): 19072 - 19077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nakano, T. Osanai, H. Tomita, M. Sekimata, Y. Homma, and K. Okumura Enhanced Activity of Variant Phospholipase C-{delta}1 Protein (R257H) Detected in Patients With Coronary Artery Spasm Circulation, April 30, 2002; 105(17): 2024 - 2029. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
