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J Biol Chem, Vol. 274, Issue 37, 26209-26216, September 10, 1999
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From the The neurotrophins have been implicated in the
acute regulation of synaptic plasticity. Neurotrophin-stimulated
presynaptic calcium uptake appears to play a key role in this process.
To understand the mechanism of neurotrophin-stimulated calcium uptake, the regulation of calcium uptake and intracellular mobilization by
nerve growth factor (NGF) was investigated using NIH 3T3 cells stably
transfected with either the high affinity NGF receptor p140trk
(3T3-Trk) or the low affinity NGF receptor p75NGFR
(3T3-p75). In 3T3-Trk cells, NGF increased both calcium uptake and
intracellular calcium mobilization. In 3T3-p75 cells, NGF increased
calcium uptake but not intracellular calcium mobilization. K-252a alone
increased intracellular calcium in 3T3-Trk cells but not in 3T3-p75
cells. Nifedipine, an inhibitor of calcium uptake through
L-type calcium channels, inhibited the action of NGF on
both 3T3-Trk cells and 3T3-p75 cells, indicating that both p140trk and p75NGFR receptors are linked to
nifedipine-sensitive L-type calcium channels. These studies
show that either NGF receptor will support increases in intracellular
calcium but that p140trk does so by increasing both uptake and
mobilization, whereas p75NGFR does so by increasing uptake only.
Section on Growth Factors,
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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