|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 38, 26946-26955, September 17, 1999
From the Departments of In chloride-secretory epithelia, the basolateral
Na-K-2Cl cotransporter (NKCC1) is thought to play a major role in
transepithelial Cl
Mice Lacking the Basolateral Na-K-2Cl Cotransporter Have Impaired
Epithelial Chloride Secretion and Are Profoundly Deaf
,
,,,,,
Molecular Genetics, Physiology,
§§ Cell Biology, Department of Biological
Sciences, University of Cincinnati, Cincinnati, Ohio 45221, and the
§ Department of Veterinary Biomedical Sciences, Dalton
Cardiovascular Research Center, University of Missouri,
Columbia, Missouri 65211
and fluid transport. Similarly,
in marginal cells of the inner ear, NKCC1 has been proposed as a
component of the entry pathway for K+ that is secreted into
the endolymph, thus playing a critical role in hearing. To test these
hypotheses, we generated and analyzed an NKCC1-deficient mouse.
Homozygous mutant (Nkcc1/) mice exhibited
growth retardation, a 28% incidence of death around the time of
weaning, and mild difficulties in maintaining their balance. Mean
arterial blood pressure was significantly reduced in both heterozygous
and homozygous mutants, indicating an important function for NKCC1 in
the maintenance of blood pressure. cAMP-induced short circuit currents,
which are dependent on the CFTR Cl channel, were reduced
in jejunum, cecum, and trachea of Nkcc1/
mice, indicating that NKCC1 contributes to cAMP-induced
Cl secretion. In contrast, secretion of gastric acid in
adult Nkcc1/ stomachs and
enterotoxin-stimulated fluid secretion in the intestine of suckling
Nkcc1/ mice were normal. Finally,
homozygous mutants were deaf, and histological analysis of the inner
ear revealed a collapse of the membranous labyrinth, consistent with a
critical role for NKCC1 in transepithelial K+ movements
involved in generation of the K+-rich endolymph and the
endocochlear potential.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. T. Sipila, K. Huttu, J. Yamada, R. Afzalov, J. Voipio, P. Blaesse, and K. Kaila Compensatory Enhancement of Intrinsic Spiking upon NKCC1 Disruption in Neonatal Hippocampus J. Neurosci., May 27, 2009; 29(21): 6982 - 6988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Yang, D. Zhao, and A. S. Verkman Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation FASEB J, February 1, 2009; 23(2): 503 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang, S. Levic, M. A. Gratton, K. J. Doyle, E. N. Yamoah, and A. E. Pegg Spermine Synthase Deficiency Leads to Deafness and a Profound Sensitivity to {alpha}-Difluoromethylornithine J. Biol. Chem., January 9, 2009; 284(2): 930 - 937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zheng, J. Kuhlicke, K. Jackel, H. K. Eltzschig, A. Singh, M. Sjoblom, B. Riederer, C. Weinhold, U. Seidler, S. P. Colgan, et al. Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium FASEB J, January 1, 2009; 23(1): 204 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Prasad, I. Bodi, J. W. Meyer, Y. Wang, M. Ashraf, S. J. Engle, T. Doetschman, K. Sisco, M. L. Nieman, M. L. Miller, et al. Impaired Cardiac Contractility in Mice Lacking Both the AE3 Formula Exchanger and the NKCC1 Na+-K+-2Cl- Cotransporter: EFFECTS ON Ca2+ HANDLING AND PROTEIN PHOSPHATASES J. Biol. Chem., November 14, 2008; 283(46): 31303 - 31314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. G. Romanenko, T. Nakamoto, M. A. Catalan, M. Gonzalez-Begne, G. J. Schwartz, Y. Jaramillo, F. V. Sepulveda, C. D. Figueroa, and J. E. Melvin Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands Am J Physiol Gastrointest Liver Physiol, November 1, 2008; 295(5): G1058 - G1067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Kim, C. Eisner, R. Faulhaber-Walter, D. Mizel, S. M. Wall, J. P. Briggs, and J. Schnermann Salt sensitivity of blood pressure in NKCC1-deficient mice Am J Physiol Renal Physiol, October 1, 2008; 295(4): F1230 - F1238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-L. Chou, M.-J. Yu, E. M. Kassai, R. G. Morris, J. D. Hoffert, S. M. Wall, and M. A. Knepper Roles of basolateral solute uptake via NKCC1 and of myosin II in vasopressin-induced cell swelling in inner medullary collecting duct Am J Physiol Renal Physiol, July 1, 2008; 295(1): F192 - F201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Choi, C. J. Lee, A. Schroeder, Y. S. Kim, S. H. Jung, J. S. Kim, D. Y. Kim, E. J. Son, H. C. Han, S. K. Hong, et al. Excitatory Actions of GABA in the Suprachiasmatic Nucleus J. Neurosci., May 21, 2008; 28(21): 5450 - 5459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fujii, Y. Takahashi, Y. Itomi, K. Fujita, M. Morii, Y. Tabuchi, S. Asano, K. Tsukada, N. Takeguchi, and H. Sakai K+-Cl- Cotransporter-3a Up-regulates Na+,K+-ATPase in Lipid Rafts of Gastric Luminal Parietal Cells J. Biol. Chem., March 14, 2008; 283(11): 6869 - 6877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Nin, H. Hibino, K. Doi, T. Suzuki, Y. Hisa, and Y. Kurachi The endocochlear potential depends on two K+ diffusion potentials and an electrical barrier in the stria vascularis of the inner ear PNAS, February 5, 2008; 105(5): 1751 - 1756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Lang, V. Vallon, M. Knipper, and P. Wangemann Functional significance of channels and transporters expressed in the inner ear and kidney Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1187 - C1208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. N. Orlov and A. A. Mongin Salt-sensing mechanisms in blood pressure regulation and hypertension Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2039 - H2053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. T. Nickell, N. K. Kleene, and S. J. Kleene Mechanisms of neuronal chloride accumulation in intact mouse olfactory epithelium J. Physiol., September 15, 2007; 583(3): 1005 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Reynolds, A. Parris, L. A. Evans, S. Lindqvist, P. Sharp, M. Lewis, R. Tighe, and M. R. Williams Dynamic and differential regulation of NKCC1 by calcium and cAMP in the native human colonic epithelium J. Physiol., July 15, 2007; 582(2): 507 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-L. Zhang, E. Delpire, and N. Vardi NKCC1 Does Not Accumulate Chloride in Developing Retinal Neurons J Neurophysiol, July 1, 2007; 98(1): 266 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Oppermann, P. B. Hansen, H. Castrop, and J. Schnermann Vasodilatation of afferent arterioles and paradoxical increase of renal vascular resistance by furosemide in mice Am J Physiol Renal Physiol, July 1, 2007; 293(1): F279 - F287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nguyen, A. J. Pace, and B. H. Koller Mice lacking NKCC1 are protected from development of bacteremia and hypothermic sepsis secondary to bacterial pneumonia J. Exp. Med., June 11, 2007; 204(6): 1383 - 1393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Orlov NKCC1 as a regulator of vascular tone and a novel target for antihypertensive therapeutics Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2035 - H2036. [Full Text] [PDF]
|
|
|
|
|
|
L. R. Gawenis, E. M. Bradford, V. Prasad, J. N. Lorenz, J. E. Simpson, L. L. Clarke, A. L. Woo, C. Grisham, L. P. Sanford, T. Doetschman, et al. Colonic Anion Secretory Defects and Metabolic Acidosis in Mice Lacking the NBC1 Formula Cotransporter J. Biol. Chem., March 23, 2007; 282(12): 9042 - 9052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Kintner, J. Luo, J. Gerdts, A. J. Ballard, G. E. Shull, and D. Sun Role of Na+-K+-Cl- cotransport and Na+/Ca2+ exchange in mitochondrial dysfunction in astrocytes following in vitro ischemia Am J Physiol Cell Physiol, March 1, 2007; 292(3): C1113 - C1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. H. Quraishi and R. M. Raphael Computational model of vectorial potassium transport by cochlear marginal cells and vestibular dark cells Am J Physiol Cell Physiol, January 1, 2007; 292(1): C591 - C602. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. T. Kahle, J. Rinehart, A. Ring, I. Gimenez, G. Gamba, S. C. Hebert, and R. P. Lifton WNK Protein Kinases Modulate Cellular Cl- Flux by Altering the Phosphorylation State of the Na-K-Cl and K-Cl Cotransporters. Physiology, October 1, 2006; 21: 326 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hibino and Y. Kurachi Molecular and physiological bases of the k+ circulation in the Mammalian inner ear. Physiology, October 1, 2006; 21: 336 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wangemann Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential J. Physiol., October 1, 2006; 576(1): 11 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Yang, D. Zhao, L. Qian, and A. S. Verkman Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion Am J Physiol Renal Physiol, August 1, 2006; 291(2): F465 - F472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Anselmo, S. Earnest, W. Chen, Y.-C. Juang, S. C. Kim, Y. Zhao, and M. H. Cobb WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells PNAS, July 18, 2006; 103(29): 10883 - 10888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Pedersen, M. E. O'Donnell, S. E. Anderson, and P. M. Cala Physiology and pathophysiology of Na+/H+ exchange and Na+-K+-2Cl- cotransport in the heart, brain, and blood Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R1 - R25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Geibel, K. Sritharan, R. Geibel, P. Geibel, J. S. Persing, A. Seeger, T. K. Roepke, M. Deichstetter, C. Prinz, S. X. Cheng, et al. Inaugural Article: Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction PNAS, June 20, 2006; 103(25): 9390 - 9397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wouters, A. D. Laet, L. V. Donck, E. Delpire, P.-P. van Bogaert, J.-P. Timmermans, A. de Kerchove d'Exaerde, K. Smans, and J.-M. Vanderwinden Subtractive hybridization unravels a role for the ion cotransporter NKCC1 in the murine intestinal pacemaker Am J Physiol Gastrointest Liver Physiol, June 1, 2006; 290(6): G1219 - G1227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Rust, J. Faulhaber, M. K. Budack, C. Pfeffer, T. Maritzen, M. Didie, F.-X. Beck, T. Boettger, R. Schubert, H. Ehmke, et al. Neurogenic Mechanisms Contribute to Hypertension in Mice With Disruption of the K-Cl Cotransporter KCC3 Circ. Res., March 3, 2006; 98(4): 549 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. T. Nickell, N. K. Kleene, R. C. Gesteland, and S. J. Kleene Neuronal Chloride Accumulation in Olfactory Epithelium of Mice Lacking NKCC1 J Neurophysiol, March 1, 2006; 95(3): 2003 - 2006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Wall, M. A. Knepper, K. A. Hassell, M. P. Fischer, A. Shodeinde, W. Shin, T. D. Pham, J. W. Meyer, J. N. Lorenz, W. H. Beierwaltes, et al. Hypotension in NKCC1 null mice: role of the kidneys Am J Physiol Renal Physiol, February 1, 2006; 290(2): F409 - F416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Beierwaltes Alternative renin regulatory pathways and the NKCC1 isoform Am J Physiol Renal Physiol, December 1, 2005; 289(6): F1183 - F1184. [Full Text] [PDF]
|
|
|
|
|
|
H. Castrop, J. N. Lorenz, P. B. Hansen, U. Friis, D. Mizel, M. Oppermann, B. L. Jensen, J. Briggs, O. Skott, and J. Schnermann Contribution of the basolateral isoform of the Na-K-2Cl- cotransporter (NKCC1/BSC2) to renin secretion Am J Physiol Renal Physiol, December 1, 2005; 289(6): F1185 - F1192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. W. Beisel, S. M. Rocha-Sanchez, K. A. Morris, L. Nie, F. Feng, B. Kachar, E. N. Yamoah, and B. Fritzsch Differential Expression of KCNQ4 in Inner Hair Cells and Sensory Neurons Is the Basis of Progressive High-Frequency Hearing Loss J. Neurosci., October 5, 2005; 25(40): 9285 - 9293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Nie, M. A. Gratton, K. J. Mu, J. N. Dinglasan, W. Feng, and E. N. Yamoah Expression and Functional Phenotype of Mouse ERG K+ Channels in the Inner Ear: Potential Role in K+ Regulation in the Inner Ear J. Neurosci., September 21, 2005; 25(38): 8671 - 8679. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Pena-Munzenmayer, M. Catalan, I. Cornejo, C. D. Figueroa, J. E. Melvin, M. I. Niemeyer, L. P. Cid, and F. V. Sepulveda Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif J. Cell Sci., September 15, 2005; 118(18): 4243 - 4252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. McDaniel, A. J. Pace, S. Spiegel, R. Engelhardt, B. H. Koller, U. Seidler, and C. Lytle Role of Na-K-2Cl cotransporter-1 in gastric secretion of nonacidic fluid and pepsinogen Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G550 - G560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Uc, R. F. Husted, R. L. Giriyappa, B. E. Britigan, and J. B. Stokes Hemin induces active chloride secretion in Caco-2 cells Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G202 - G208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Kreindler, A. D. Jackson, P. A. Kemp, R. J. Bridges, and H. Danahay Inhibition of chloride secretion in human bronchial epithelial cells by cigarette smoke extract Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L894 - L902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Gamba Molecular Physiology and Pathophysiology of Electroneutral Cation-Chloride Cotransporters Physiol Rev, April 1, 2005; 85(2): 423 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Gawenis, J. M. Greeb, V. Prasad, C. Grisham, L. P. Sanford, T. Doetschman, A. Andringa, M. L. Miller, and G. E. Shull Impaired Gastric Acid Secretion in Mice with a Targeted Disruption of the NHE4 Na+/H+ Exchanger J. Biol. Chem., April 1, 2005; 280(13): 12781 - 12789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Gawenis, H. Hut, A. G. M. Bot, G. E. Shull, H. R. de Jonge, X. Stien, M. L. Miller, and L. L. Clarke Electroneutral sodium absorption and electrogenic anion secretion across murine small intestine are regulated in parallel Am J Physiol Gastrointest Liver Physiol, December 1, 2004; 287(6): G1140 - G1149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lenart, D. B. Kintner, G. E. Shull, and D. Sun Na-K-Cl Cotransporter-Mediated Intracellular Na+ Accumulation Affects Ca2+ Signaling in Astrocytes in an In Vitro Ischemic Model J. Neurosci., October 27, 2004; 24(43): 9585 - 9597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Gawenis, C. Ledoussal, L. M. Judd, V. Prasad, S. L. Alper, A. Stuart-Tilley, A. L. Woo, C. Grisham, L. P. Sanford, T. Doetschman, et al. Mice with a Targeted Disruption of the AE2 Cl-/HCO3- Exchanger Are Achlorhydric J. Biol. Chem., July 16, 2004; 279(29): 30531 - 30539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nakamura, M. Matsui, K. Uchida, A. Futatsugi, S. Kusakawa, N. Matsumoto, K. Nakamura, T. Manabe, M. M. Taketo, and K. Mikoshiba M3 muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice J. Physiol., July 15, 2004; 558(2): 561 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Gawenis, K. T. Boyle, B. A. Palmer, N. M. Walker, and L. L. Clarke Lateral intercellular space volume as a determinant of CFTR-mediated anion secretion across small intestinal mucosa Am J Physiol Gastrointest Liver Physiol, June 1, 2004; 286(6): G1015 - G1023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Shin, W. Namkung, J. Y. Choi, J.-H. Yoon, and M. G. Lee Purinergic Stimulation Induces Ca2+-dependent Activation of Na+-K+-2Cl- Cotransporter in Human Nasal Epithelia J. Biol. Chem., April 30, 2004; 279(18): 18567 - 18574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Jiang, F. Akar, S. L. Cobbs, K. Lomashvilli, R. Lakkis, F. J. Gordon, R. L. Sutliff, and W. C. O'Neill Blood pressure regulates the activity and function of the Na-K-2Cl cotransporter in vascular smooth muscle Am J Physiol Heart Circ Physiol, April 1, 2004; 286(4): H1552 - H1557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O Bachmann, K Wuchner, H Rossmann, J Leipziger, B Osikowska, W H Colledge, R Ratcliff, M J Evans, M Gregor, and U Seidler Expression and regulation of the Na+-K+-2Cl- cotransporter NKCC1 in the Normal and CFTR-deficient murine colon J. Physiol., June 1, 2003; 549(2): 525 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Meyer, M. Flagella, R. L. Sutliff, J. N. Lorenz, M. L. Nieman, C. S. Weber, R. J. Paul, and G. E. Shull Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na+-K+-2Cl- cotransporter Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H1846 - H1855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Hubner and T. J. Jentsch Ion channel diseases Hum. Mol. Genet., October 1, 2002; 11(20): 2435 - 2445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Lorenz, N. R. Baird, L. M. Judd, W. T. Noonan, A. Andringa, T. Doetschman, P. A. Manning, L. H. Liu, M. L. Miller, and G. E. Shull Impaired Renal NaCl Absorption in Mice Lacking the ROMK Potassium Channel, a Model for Type II Bartter's Syndrome J. Biol. Chem., September 27, 2002; 277(40): 37871 - 37880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Shillingford, K. Miyoshi, M. Flagella, G. E. Shull, and L. Hennighausen Mouse Mammary Epithelial Cells Express the Na-K-Cl Cotransporter, NKCC1: Characterization, Localization, and Involvement in Ductal Development and Morphogenesis Mol. Endocrinol., June 1, 2002; 16(6): 1309 - 1321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Athman, A. Tsocas, O. Presset, S. Robine, C. Roze, and E. Ferrary In vivo absorption of water and electrolytes in mouse intestine. Application to villin -/- mice Am J Physiol Gastrointest Liver Physiol, April 1, 2002; 282(4): G634 - G639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Warth and J. Barhanin The multifaceted phenotype of the knockout mouse for the KCNE1 potassium channel gene Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R639 - R648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kunzelmann and M. Mall Electrolyte Transport in the Mammalian Colon: Mechanisms and Implications for Disease Physiol Rev, January 1, 2002; 82(1): 245 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Singh, A. Mennone, A. Gigliozzi, F. Fraioli, and J. L. Boyer Cl{-}-dependent secretory mechanisms in isolated rat bile duct epithelial units Am J Physiol Gastrointest Liver Physiol, August 1, 2001; 281(2): G438 - G446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Grubb, A. J. Pace, E. Lee, B. H. Koller, and R. C. Boucher Alterations in airway ion transport in NKCC1-deficient mice Am J Physiol Cell Physiol, August 1, 2001; 281(2): C615 - C623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Chaudhry, J. Gazzard, C. Baldock, J. Dixon, M. J. Rock, G. C. Skinner, K. P. Steel, C. M. Kielty, and M. J. Dixon Mutation of the gene encoding fibrillin-2 results in syndactyly in mice Hum. Mol. Genet., April 1, 2001; 10(8): 835 - 843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. IKEBE, H. NONOGUCHI, Y. NAKAYAMA, Y. TASHIMA, and K. TOMITA Upregulation of the Secretory-Type Na+/K+/2Cl--Cotransporter in the Kidney by Metabolic Acidosis and Dehydration in Rats J. Am. Soc. Nephrol., March 1, 2001; 12(3): 423 - 430. [Abstract] [Full Text]
|
|
|
|
|
|
M. C. Casimiro, B. C. Knollmann, S. N. Ebert, J. C. Vary Jr., A. E. Greene, M. R. Franz, A. Grinberg, S. P. Huang, and K. Pfeifer Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange- Nielsen Syndrome PNAS, February 27, 2001; 98(5): 2526 - 2531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Michea, V. Irribarra, I. A. Goecke, and E. T. Marusic Reduced Na-K pump but increased Na-K-2Cl cotransporter in aorta of streptozotocin-induced diabetic rat Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H851 - H858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. MENETON Comparative Roles of the Renal Apical Sodium Transport Systems in Blood Pressure Control J. Am. Soc. Nephrol., November 1, 2000; 11(90002): S135 - S139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-W. Sung, M. Kirby, M. P. McDonald, D. M. Lovinger, and E. Delpire Abnormal GABAA Receptor-Mediated Currents in Dorsal Root Ganglion Neurons Isolated from Na-K-2Cl Cotransporter Null Mice J. Neurosci., October 15, 2000; 20(20): 7531 - 7538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Grubb, E. Lee, A. J. Pace, B. H. Koller, and R. C. Boucher Intestinal ion transport in NKCC1-deficient mice Am J Physiol Gastrointest Liver Physiol, October 1, 2000; 279(4): G707 - G718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sonnentag, W.-K. Siegel, O. Bachmann, H. Rossmann, A. Mack, H.-J. Wagner, M. Gregor, and U. Seidler Agonist-induced cytoplasmic volume changes in cultured rabbit parietal cells Am J Physiol Gastrointest Liver Physiol, July 1, 2000; 279(1): G40 - G48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Shull, M. L. Miller, and P. J. Schultheis Lessons from Genetically Engineered Animal Models. VIII. Absorption and secretion of ions in the gastrointestinal tract Am J Physiol Gastrointest Liver Physiol, February 1, 2000; 278(2): G185 - G190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cuppoletti An ion transporter involved in congenital deafness Focus on "Human pendrin expressed in Xenopus laevis oocytes mediates chloride/formate exchange" Am J Physiol Cell Physiol, January 1, 2000; 278(1): C11 - C12. [Full Text] [PDF]
|
|
|
|
|
|
R. L. Evans, K. Park, R. J. Turner, G. E. Watson, H.-V. Nguyen, M. R. Dennett, A. R. Hand, M. Flagella, G. E. Shull, and J. E. Melvin Severe Impairment of Salivation in Na+/K+/2Cl- Cotransporter (NKCC1)-deficient Mice J. Biol. Chem., August 25, 2000; 275(35): 26720 - 26726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gerelsaikhan and R. J. Turner Transmembrane Topology of the Secretory Na+-K+-2Cl- Cotransporter NKCC1 Studied by in Vitro Translation J. Biol. Chem., December 15, 2000; 275(51): 40471 - 40477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Dolganov, P. G. Woodruff, A. A. Novikov, Y. Zhang, R. E. Ferrando, R. Szubin, and J. V. Fahy A Novel Method of Gene Transcript Profiling in Airway Biopsy Homogenates Reveals Increased Expression of a Na+-K+-Cl- Cotransporter (NKCC1) in Asthmatic Subjects Genome Res., September 1, 2001; 11(9): 1473 - 1483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. C. Sun and J. A. Bonanno Expression, localization, and functional evaluation of CFTR in bovine corneal endothelial cells Am J Physiol Cell Physiol, April 1, 2002; 282(4): C673 - C683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Su, D. B. Kintner, M. Flagella, G. E. Shull, and D. Sun Astrocytes from Na+-K+-Cl- cotransporter-null mice exhibit absence of swelling and decrease in EAA release Am J Physiol Cell Physiol, May 1, 2002; 282(5): C1147 - C1160. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |