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J Biol Chem, Vol. 274, Issue 38, 27076-27082, September 17, 1999
From the The mammalian cation-independent mannose
6-phosphate receptor (CI-MPR) binds mannose 6-phosphate-bearing
glycoproteins and insulin-like growth factor (IGF)-II. However, the
CI-MPR from the opossum has been reported to bind bovine IGF-II with
low affinity (Dahms, N. M., Brzycki-Wessell, M. A.,
Ramanujam, K. S., and Seetharam, B. (1993)
Endocrinology 133, 440-446). This may reflect the use of a
heterologous ligand, or it may represent the intrinsic binding affinity
of this receptor. To examine the binding of IGF-II to a marsupial
CI-MPR in a homologous system, we have previously purified kangaroo
IGF-II (Yandell, C. A., Francis, G. L., Wheldrake, J. F., and Upton, Z. (1998) J. Endocrinol. 156, 195-204), and we now report the purification and characterization of the CI-MPR from
kangaroo liver. The interaction of the kangaroo CI-MPR with IGF-II has
been examined by ligand blotting, radioreceptor assay, and real-time
biomolecular interaction analysis. Using both a heterologous and
homologous approach, we have demonstrated that the kangaroo CI-MPR has
a lower binding affinity for IGF-II than its eutherian (placental
mammal) counterparts. Furthermore, real-time biomolecular interaction
analysis revealed that the kangaroo CI-MPR has a higher affinity for
kangaroo IGF-II than for human IGF-II. The cDNA sequence of the
kangaroo CI-MPR indicates that there is considerable divergence in the
area corresponding to the IGF-II binding site of the eutherian
receptor. Thus, the acquisition of a high-affinity binding site for
regulating IGF-II appears to be a recent event specific to the
eutherian lineage.
The Kangaroo Cation-independent Mannose 6-Phosphate Receptor
Binds Insulin-like Growth Factor II with Low Affinity
§¶,§,¶, and§
Cooperative Research Centre for Tissue
Growth and Repair, P. O. Box 10065, Adelaide B.C., South Australia,
Australia, 5000, § CSIRO Human Nutrition, P. O. Box 10041, Adelaide B.C., South Australia, Australia, 5000, and ¶ School of
Biological Sciences, Flinders University of South Australia, GPO 2100, Adelaide, South Australia, Australia, 5001
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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