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J Biol Chem, Vol. 274, Issue 39, 27343-27346, September 24, 1999
§,
From the Macromolecular centromere-kinetochore complex
plays a critical role in sister chromatid separation, but its complete
protein composition as well as its precise dynamic function during
mitosis has not yet been clearly determined. Here we report the
isolation of a novel mouse kinetochore protein, CENP-H. The CENP-H,
with an apparent molecular mass of 33 kDa, was found to contain a
coiled-coil structure and a nuclear localization signal. The CENP-H
transcripts were relatively scarce but were detectable in most tissues
and embryos at various stages of development. Immunofluorescence
stainings of mouse fibroblast cells with anti-CENP-H-specific antibody
demonstrated that the CENP-H is specifically and constitutively
localized in kinetochores throughout the cell cycle; this was also
confirmed by stainings with anti-centromere-specific antibody. Thus the newly isolated CENP-H may play a role in kinetochore organization and
function throughout the cell cycle.
Tsukuba Life Science Center, The
Institute of Physical and Chemical Research (RIKEN), 3-1, Koyadai,
Tsukuba, Ibaraki 305-0074, Japan and the § Institute of
Applied Biochemistry, Tsukuba University, 1-1, Tennoudai, Tsukuba,
Ibaraki 305-8572, Japan
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