| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 39, 27545-27552, September 24, 1999
,,,
, and
From the Mitogen-activated protein kinase (MAPK) cascades
are activated by diverse extracellular signals and participate in the
regulation of an array of cellular programs. In this study, we
investigated the roles of MAPKs in the induction of phase II
detoxifying enzymes by chemicals. Treatment of human hepatoma (HepG2)
and murine hepatoma (Hepa1c1c7) cells with
tert-butylhydroquinone (tBHQ) or sulforaphane (SUL), two
potent phase II enzyme inducers, stimulated the activity of
extracellular signal-regulated protein kinase 2 (ERK2) but not c-Jun
N-terminal kinase 1. tBHQ and SUL also activated MAPK kinase.
Inhibition of MAPK kinase with its inhibitor, PD98059, abolished ERK2
activation and impaired the induction of quinone reductase, a phase II
detoxifying enzyme, and antioxidant response element (ARE)-linked
reporter gene by tBHQ and SUL. Overexpression of a dominant-negative
mutant of ERK2 also attenuated tBHQ and SUL induction of ARE reporter
gene activity. Interestingly, although expression of Ras and its mutant
forms showed distinct effects on basal ARE reporter gene activity, they
did not affect the activation of reporter gene by the inducers.
Furthermore, a dominant-negative mutant of Ras had little effect on
ERK2 activation by tBHQ and SUL, implicating a Ras-independent
mechanism. Indeed, both tBHQ and SUL were able to stimulate Raf-1
kinase activity in vivo as well as in vitro.
Thus, our results indicate that the induction of
ARE-dependent phase II detoxifying enzymes is mediated by a MAPK pathway, which may involve direct activation of Raf-1 by the inducers.
Department of Pharmaceutics and
Pharmacodynamics, Center for Pharmaceutical Biotechnology, College of
Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, the § Department of Microbiology, University of Virginia,
Charlottesville, Virginia 22908, the ¶ Department of Pharmacology,
Lineberger Comprehensive Cancer Center, University of North Carolina,
Chapel Hill, North Carolina 27599, and the H. Lee Moffitt Cancer
Center and Department of Medical Microbiology and Immunology,
University of South Florida, Tampa, Florida 33612
This article has been cited by other articles:
|
|
 |
|
  R. Ghose, D. White, T. Guo, J. Vallejo, and S. J. Karpen Regulation of Hepatic Drug-Metabolizing Enzyme Genes by Toll-Like Receptor 4 Signaling Is Independent of Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein Drug Metab. Dispos., January 1, 2008; 36(1): 95 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Y. Lee, C. Y. Han, J. W. Yang, C. Smith, S. K. Kim, E. Y.-H. P. Lee, S. G. Kim, and K. W. Kang Induction of Glutathione Transferase in Insulin-Like Growth Factor Type I Receptor-Overexpressed Hepatoma Cells Mol. Pharmacol., October 1, 2007; 72(4): 1082 - 1093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Aleksunes and J. E. Manautou Invited Review: Emerging Role of Nrf2 in Protecting Against Hepatic and Gastrointestinal Disease Toxicol Pathol, June 1, 2007; 35(4): 459 - 473. [Abstract] [PDF]
|
|
|
|
 |
|
 S. G. Kim and S. J. Lee PI3K, RSK, and mTOR Signal Networks for the GST Gene Regulation Toxicol. Sci., April 1, 2007; 96(2): 206 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Liu, J. T. Kern, J. R. Walker, J. A. Johnson, P. G. Schultz, and H. Luesch A genomic screen for activators of the antioxidant response element PNAS, March 20, 2007; 104(12): 5205 - 5210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Gupta, K. P. Miller, J. K. Babus, and J. A. Flaws Methoxychlor Inhibits Growth and Induces Atresia of Antral Follicles through an Oxidative Stress Pathway Toxicol. Sci., October 1, 2006; 93(2): 382 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Xu, X. Yuan, Z. Pan, G. Shen, J.-H. Kim, S. Yu, T. O. Khor, W. Li, J. Ma, and A.-N. T. Kong Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Mol. Cancer Ther., August 1, 2006; 5(8): 1918 - 1926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-T. Yeh and G.-C. Yen Involvement of p38 MAPK and Nrf2 in phenolic acid-induced P-form phenol sulfotransferase expression in human hepatoma HepG2 cells Carcinogenesis, May 1, 2006; 27(5): 1008 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Kim, M. A. Abdelmegeed, and R. F. Novak THE MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MEK) INHIBITOR PD98059 ELEVATES PRIMARY CULTURED RAT HEPATOCYTE GLUTATHIONE LEVELS INDEPENDENT OF INHIBITING MEK Drug Metab. Dispos., April 1, 2006; 34(4): 683 - 689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhang, H. Liu, K. E. Iles, R.-M. Liu, E. M. Postlethwait, Y. Laperche, and H. J. Forman 4-Hydroxynonenal Induces Rat {gamma}-Glutamyl Transpeptidase through Mitogen-Activated Protein Kinase-Mediated Electrophile Response Element/Nuclear Factor Erythroid 2-Related Factor 2 Signaling Am. J. Respir. Cell Mol. Biol., February 1, 2006; 34(2): 174 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-J. Surh, J. K. Kundu, H.-K. Na, and J.-S. Lee Redox-Sensitive Transcription Factors as Prime Targets for Chemoprevention with Anti-Inflammatory and Antioxidative Phytochemicals J. Nutr., December 1, 2005; 135(12): 2993S - 3001S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Feng, Y. Lu, L. L. Bowman, Y. Qian, V. Castranova, and M. Ding Inhibition of Activator Protein-1, NF-{kappa}B, and MAPKs and Induction of Phase 2 Detoxifying Enzyme Activity by Chlorogenic Acid J. Biol. Chem., July 29, 2005; 280(30): 27888 - 27895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Svehlikova, S. Wang, J. Jakubikova, G. Williamson, R. Mithen, and Y. Bao Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells Carcinogenesis, September 1, 2004; 25(9): 1629 - 1637. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Hu, V. Hebbar, B.-R. Kim, C. Chen, B. Winnik, B. Buckley, P. Soteropoulos, P. Tolias, R. P. Hart, and A.-N. T. Kong In Vivo Pharmacokinetics and Regulation of Gene Expression Profiles by Isothiocyanate Sulforaphane in the Rat J. Pharmacol. Exp. Ther., July 1, 2004; 310(1): 263 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Pullar, S. J. Thomson, M. J. King, C. I. Turnbull, R. G. Midwinter, and M. B. Hampton The chemopreventive agent phenethyl isothiocyanate sensitizes cells to Fas-mediated apoptosis Carcinogenesis, May 1, 2004; 25(5): 765 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Bloom and A. K. Jaiswal Phosphorylation of Nrf2 at Ser40 by Protein Kinase C in Response to Antioxidants Leads to the Release of Nrf2 from INrf2, but Is Not Required for Nrf2 Stabilization/Accumulation in the Nucleus and Transcriptional Activation of Antioxidant Response Element-mediated NAD(P)H:Quinone Oxidoreductase-1 Gene Expression J. Biol. Chem., November 7, 2003; 278(45): 44675 - 44682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.-R. Kim, R. Hu, Y.-S. Keum, V. Hebbar, G. Shen, S. S. Nair, and A-N. T. Kong Effects of Glutathione on Antioxidant Response Element-Mediated Gene Expression and Apoptosis Elicited by Sulforaphane Cancer Res., November 1, 2003; 63(21): 7520 - 7525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Lee, M. J. Calkins, K. Chan, Y. W. Kan, and J. A. Johnson Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis J. Biol. Chem., March 28, 2003; 278(14): 12029 - 12038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. W. Kang, E. Y. Park, and S. G. Kim Activation of CCAAT/enhancer-binding protein {beta} by 2'-amino-3'-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2 Carcinogenesis, March 1, 2003; 24(3): 475 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nguyen, P. J. Sherratt, H.-C. Huang, C. S. Yang, and C. B. Pickett Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element. DEGRADATION OF Nrf2 BY THE 26 S PROTEASOME J. Biol. Chem., February 7, 2003; 278(7): 4536 - 4541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. W. Kang, I. J. Cho, C. H. Lee, and S. G. Kim Essential Role of Phosphatidylinositol 3-Kinase-Dependent CCAAT/Enhancer Binding Protein {beta} Activation in the Induction of Glutathione S-Transferase by Oltipraz J Natl Cancer Inst, January 1, 2003; 95(1): 53 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Misra, E. D. Owuor, W. Li, S. Yu, C. Qi, K. Meyer, Y.-J. Zhu, M. S. Rao, A.-N. T. Kong, and J. K. Reddy Phosphorylation of Transcriptional Coactivator Peroxisome Proliferator-activated Receptor (PPAR)-binding Protein (PBP). STIMULATION OF TRANSCRIPTIONAL REGULATION BY MITOGEN-ACTIVATED PROTEIN KINASE J. Biol. Chem., December 6, 2002; 277(50): 48745 - 48754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Huang, T. Nguyen, and C. B. Pickett Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription J. Biol. Chem., November 1, 2002; 277(45): 42769 - 42774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. P. Basten, Y. Bao, and G. Williamson Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells Carcinogenesis, August 1, 2002; 23(8): 1399 - 1404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Le Ferrec, D. Lagadic-Gossmann, C. Rauch, C. Bardiau, K. Maheo, F. Massiere, M. Le Vee, A. Guillouzo, and F. Morel Transcriptional Induction of CYP1A1 by Oltipraz in Human Caco-2 Cells Is Aryl Hydrocarbon Receptor- and Calcium-dependent J. Biol. Chem., June 28, 2002; 277(27): 24780 - 24787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Fimognari, M. Nusse, R. Cesari, R. Iori, G. Cantelli-Forti, and P. Hrelia Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane Carcinogenesis, April 1, 2002; 23(4): 581 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Morimitsu, Y. Nakagawa, K. Hayashi, H. Fujii, T. Kumagai, Y. Nakamura, T. Osawa, F. Horio, K. Itoh, K. Iida, et al. A Sulforaphane Analogue That Potently Activates the Nrf2-dependent Detoxification Pathway J. Biol. Chem., January 25, 2002; 277(5): 3456 - 3463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, J.-M. Lee, and J. A. Johnson Microarray Analysis Reveals an Antioxidant Responsive Element-driven Gene Set Involved in Conferring Protection from an Oxidative Stress-induced Apoptosis in IMR-32 Cells J. Biol. Chem., January 4, 2002; 277(1): 388 - 394. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Jorquera and R. M. Tanguay Fumarylacetoacetate, the metabolite accumulating in hereditary tyrosinemia, activates the ERK pathway and induces mitotic abnormalities and genomic instability Hum. Mol. Genet., August 1, 2001; 10(17): 1741 - 1752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. W. Kang, M. K. Cho, C. H. Lee, and S. G. Kim Activation of Phosphatidylinositol 3-Kinase and Akt by tert-Butylhydroquinone Is Responsible for Antioxidant Response Element-Mediated rGSTA2 Induction in H4IIE Cells Mol. Pharmacol., April 16, 2001; 59(5): 1147 - 1156. [Abstract] [Full Text]
|
|
|
|
|
|
C. R. Wolf Chemoprevention: Increased potential to bear fruit PNAS, March 13, 2001; 98(6): 2941 - 2943. [Full Text] [PDF]
|
|
|
|
|
|
K. W. Kang, J. H. Ryu, and S. G. Kim The Essential Role of Phosphatidylinositol 3-Kinase and of p38 Mitogen-Activated Protein Kinase Activation in the Antioxidant Response Element-Mediated rGSTA2 Induction by Decreased Glutathione in H4IIE Hepatoma Cells Mol. Pharmacol., November 1, 2000; 58(5): 1017 - 1025. [Abstract] [Full Text]
|
|
|
|
|
|
H.-C. Huang, T. Nguyen, and C. B. Pickett Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2 PNAS, October 12, 2000; (2000) 220418997. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Kawamoto, Y. Nakamura, Y. Naito, Y. Torii, T. Kumagai, T. Osawa, H. Ohigashi, K. Satoh, M. Imagawa, and K. Uchida Cyclopentenone Prostaglandins as Potential Inducers of Phase II Detoxification Enzymes. 15-DEOXY-Delta 12,14-PROSTAGLANDIN J2-INDUCED EXPRESSION OF GLUTATHIONE S-TRANSFERASES J. Biol. Chem., April 6, 2000; 275(15): 11291 - 11299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Yu, S. Mandlekar, W. Lei, W. E. Fahl, T.-H. Tan, and A.-N. T. Kong p38 Mitogen-activated Protein Kinase Negatively Regulates the Induction of Phase II Drug-metabolizing Enzymes That Detoxify Carcinogens J. Biol. Chem., January 28, 2000; 275(4): 2322 - 2327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nguyen, H. C. Huang, and C. B. Pickett Transcriptional Regulation of the Antioxidant Response Element. ACTIVATION BY Nrf2 AND REPRESSION BY MafK J. Biol. Chem., May 12, 2000; 275(20): 15466 - 15473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Montano, B. M. Wittmann, and N. R. Bianco Identification and Characterization of a Novel Factor That Regulates Quinone Reductase Gene Transcriptional Activity J. Biol. Chem., October 27, 2000; 275(44): 34306 - 34313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Yu, C. Chen, Y.-Y. Mo, V. Hebbar, E. D. Owuor, T.-H. Tan, and A.-N. T. Kong Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism J. Biol. Chem., December 15, 2000; 275(51): 39907 - 39913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Lee, J. M. Hanson, W. A. Chu, and J. A. Johnson Phosphatidylinositol 3-Kinase, Not Extracellular Signal-regulated Kinase, Regulates Activation of the Antioxidant-Responsive Element in IMR-32 Human Neuroblastoma Cells J. Biol. Chem., June 1, 2001; 276(23): 20011 - 20016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Heiss, C. Herhaus, K. Klimo, H. Bartsch, and C. Gerhauser Nuclear Factor kappa B Is a Molecular Target for Sulforaphane-mediated Anti-inflammatory Mechanisms J. Biol. Chem., August 17, 2001; 276(34): 32008 - 32015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Huang, T. Nguyen, and C. B. Pickett Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2 PNAS, November 7, 2000; 97(23): 12475 - 12480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Day, Y. j. Suzuki, J. M. Lum, A. C. White, and B. L. Fanburg Bleomycin upregulates expression of gamma -glutamylcysteine synthetase in pulmonary artery endothelial cells Am J Physiol Lung Cell Mol Physiol, June 1, 2002; 282(6): L1349 - L1357. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
