| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 4, 1869-1872, January 22, 1999
From the Department of Biochemistry, Tohoku University School of
Medicine, Sendai 980-8575, Miyagi, Japan
Increases in
[Ca2+]i in pancreatic beta
cells, resulting from Ca2+ mobilization from intracellular
stores as well as Ca2+ influx from extracellular sources,
are important in insulin secretion by glucose. Cyclic ADP-ribose
(cADPR), accumulated in beta cells by glucose stimulation, has been
postulated to serve as a second messenger for intracellular
Ca2+ mobilization for insulin secretion, and CD38 is
thought to be involved in the cADPR accumulation (Takasawa, S., Tohgo,
A., Noguchi, N., Koguma, T., Nata, K., Sugimoto, T., Yonekura, H., and
Okamoto, H. (1993) J. Biol. Chem. 268, 26052-26054).
Here we created "knockout" (CD38
/) mice by
homologous recombination. CD38/ mice developed normally
but showed no increase in their glucose-induced production of cADPR in
pancreatic islets. The glucose-induced [Ca2+]i rise and insulin
secretion were both severely impaired in CD38/ islets,
whereas CD38/ islets responded normally to the
extracellular Ca2+ influx stimulants tolbutamide and KCl.
CD38/ mice showed impaired glucose tolerance, and the
serum insulin level was lower than control, and these impaired
phenotypes were rescued by beta cell-specific expression of CD38
cDNA. These results indicate that CD38 plays an essential role in
intracellular Ca2+ mobilization by cADPR for insulin secretion.
This article has been cited by other articles:
|
|
 |
|
  B.-J. Kim, K.-H. Park, C.-Y. Yim, S. Takasawa, H. Okamoto, M.-J. Im, and U.-H. Kim Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca2+ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets Diabetes, April 1, 2008; 57(4): 868 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. P. Barbosa, S. M. Soares, C. M. Novak, D. Sinclair, J. A. Levine, P. Aksoy, and E. N. Chini The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity FASEB J, November 1, 2007; 21(13): 3629 - 3639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Liu, I. A. Kriksunov, C. Moreau, R. Graeff, B. V. L. Potter, H. C. Lee, and Q. Hao Catalysis-associated Conformational Changes Revealed by Human CD38 Complexed with a Non-hydrolyzable Substrate Analog J. Biol. Chem., August 24, 2007; 282(34): 24825 - 24832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. P. Guedes, J. Paulin, L. Rivero-Nava, H. Kita, F. E. Lund, and M. S. Kannan CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge Am J Physiol Lung Cell Mol Physiol, December 1, 2006; 291(6): L1286 - L1293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Johnson, E. L. Ford, E. Bernal-Mizrachi, K. L. Kusser, D. S. Luciani, Z. Han, H. Tran, T. D. Randall, F. E. Lund, and K. S. Polonsky Suppressed insulin signaling and increased apoptosis in CD38-null islets. Diabetes, October 1, 2006; 55(10): 2737 - 2746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-M. Myint, Y. Yamamoto, T. Doi, I. Kato, A. Harashima, H. Yonekura, T. Watanabe, H. Shinohara, M. Takeuchi, K. Tsuneyama, et al. RAGE Control of Diabetic Nephropathy in a Mouse Model: Effects of RAGE Gene Disruption and Administration of Low-Molecular Weight Heparin Diabetes, September 1, 2006; 55(9): 2510 - 2522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-G. Chen, J. Chen, M. A. Osborne, H. D. Chapman, G. S. Besra, S. A. Porcelli, E. H. Leiter, S. B. Wilson, and D. V. Serreze CD38 Is Required for the Peripheral Survival of Immunotolerogenic CD4+ Invariant NK T Cells in Nonobese Diabetic Mice. J. Immunol., September 1, 2006; 177(5): 2939 - 2947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. E. Lund, H. Muller-Steffner, H. Romero-Ramirez, M. E. Moreno-Garcia, S. Partida-Sanchez, M. Makris, N. J. Oppenheimer, L. Santos-Argumedo, and F. Schuber CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism Int. Immunol., July 1, 2006; 18(7): 1029 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chen, Y.-G. Chen, P. C. Reifsnyder, W. H. Schott, C.-H. Lee, M. Osborne, F. Scheuplein, F. Haag, F. Koch-Nolte, D. V. Serreze, et al. Targeted Disruption of CD38 Accelerates Autoimmune Diabetes in NOD/Lt Mice by Enhancing Autoimmunity in an ADP-Ribosyltransferase 2-Dependent Fashion. J. Immunol., April 15, 2006; 176(8): 4590 - 4599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Deshpande, T. A. White, S. Dogan, T. F. Walseth, R. A. Panettieri, and M. S. Kannan CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L773 - L788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Krebs, S. Adriouch, F. Braasch, W. Koestner, E. H. Leiter, M. Seman, F. E. Lund, N. Oppenheimer, F. Haag, and F. Koch-Nolte CD38 Controls ADP-Ribosyltransferase-2-Catalyzed ADP-Ribosylation of T Cell Surface Proteins J. Immunol., March 15, 2005; 174(6): 3298 - 3305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Deshpande, T. A. White, A. G. P. Guedes, C. Milla, T. F. Walseth, F. E. Lund, and M. S. Kannan Altered Airway Responsiveness in CD38-Deficient Mice Am. J. Respir. Cell Mol. Biol., February 1, 2005; 32(2): 149 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. DE FLORA, E. ZOCCHI, L. GUIDA, L. FRANCO, and S. BRUZZONE Autocrine and Paracrine Calcium Signaling by the CD38/NAD+/Cyclic ADP-Ribose System Ann. N.Y. Acad. Sci., December 1, 2004; 1028(1): 176 - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Thompson, H. Barata da Silva, W. Zielinska, T. A. White, J. P. Bailey, F. E. Lund, G. C. Sieck, and E. N. Chini Role of CD38 in myometrial Ca2+ transients: modulation by progesterone Am J Physiol Endocrinol Metab, December 1, 2004; 287(6): E1142 - E1148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Deshpande, S. Dogan, T. F. Walseth, S. M. Miller, Y. Amrani, R. A. Panettieri, and M. S. Kannan Modulation of Calcium Signaling by Interleukin-13 in Human Airway Smooth Muscle: Role of CD38/Cyclic Adenosine Diphosphate Ribose Pathway Am. J. Respir. Cell Mol. Biol., July 1, 2004; 31(1): 36 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sasamori, T. Sasaki, S. Takasawa, T. Tamada, M. Nara, T. Irokawa, S. Shimura, K. Shirato, and T. Hattori Cyclic ADP-ribose, a putative Ca2+-mobilizing second messenger, operates in submucosal gland acinar cells Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L69 - L78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Srivastava and H. J. Goren Insulin Constitutively Secreted by {beta}-Cells Is Necessary for Glucose-Stimulated Insulin Secretion Diabetes, August 1, 2003; 52(8): 2049 - 2056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Mitchell, F. A. Lai, and G. A. Rutter Ryanodine Receptor Type I and Nicotinic Acid Adenine Dinucleotide Phosphate Receptors Mediate Ca2+ Release from Insulin-containing Vesicles in Living Pancreatic beta -Cells (MIN6) J. Biol. Chem., March 21, 2003; 278(13): 11057 - 11064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. SUN, J. IQBAL, S. DOLGILEVICH, T. YUEN, X.-B. WU, B. S. MOONGA, O. A. ADEBANJO, P. J. R. BEVIS, F. LUND, C. L.-H. HUANG, et al. Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption FASEB J, March 1, 2003; 17(3): 369 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Cancela and O. H. Petersen Regulation of Intracellular Ca2+ Stores by Multiple Ca2+-Releasing Messengers Diabetes, December 1, 2002; 51(90003): S349 - 357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Okamoto and S. Takasawa Recent Advances in the Okamoto Model: The CD38-Cyclic ADP-Ribose Signal System and the Regenerating Gene Protein (Reg)-Reg Receptor System in {beta}-Cells Diabetes, December 1, 2002; 51(90003): S462 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Unno, K. Nata, N. Noguchi, Y. Narushima, T. Akiyama, T. Ikeda, K. Nakagawa, S. Takasawa, and H. Okamoto Production and Characterization of Reg Knockout Mice: Reduced Proliferation of Pancreatic {beta}-Cells in Reg Knockout Mice Diabetes, December 1, 2002; 51(90003): S478 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Johnson and S. Misler Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells PNAS, October 29, 2002; 99(22): 14566 - 14571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kaku, K. Horikawa, Y. Obata, I. Kato, H. Okamoto, N. Sakaguchi, S. Gerondakis, and K. Takatsu NF-{kappa}B is required for CD38-mediated induction of C{gamma}1 germline transcripts in murine B lymphocytes Int. Immunol., September 1, 2002; 14(9): 1055 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Islam The Ryanodine Receptor Calcium Channel of {beta}-Cells: Molecular Regulation and Physiological Significance Diabetes, May 1, 2002; 51(5): 1299 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. SUN, O. A. ADEBANJO, A. KOVAL, H. K. ANANDATHEERTHAVARADA, J. IQBAL, X. Y. WU, B. S. MOONGA, X. B. WU, G. BISWAS, P. J. R. BEVIS, et al. A novel mechanism for coupling cellular intermediary metabolism to cytosolic Ca2+ signaling via CD38/ADP-ribosyl cyclase, a putative intracellular NAD+ sensor FASEB J, March 1, 2002; 16(3): 302 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-K. Han, S.-J. Kim, Y.-R. Park, Y.-M. Shin, H.-J. Park, K.-J. Park, K.-H. Park, H.-K. Kim, S.-I. Jang, N.-H. An, et al. Antidiabetic Effect of a Prodrug of Cysteine, L-2-Oxothiazolidine-4-carboxylic Acid, through CD38 Dimerization and Internalization J. Biol. Chem., February 8, 2002; 277(7): 5315 - 5321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mallone, E. Ortolan, G. Baj, A. Funaro, S. Giunti, E. Lillaz, F. Saccucci, M. Cassader, P. Cavallo-Perin, and F. Malavasi Autoantibody Response to CD38 in Caucasian Patients With Type 1 and Type 2 Diabetes: Immunological and Genetic Characterization Diabetes, April 1, 2001; 50(4): 752 - 762. [Abstract] [Full Text]
|
|
|
|
|
|
T. Akiyama, S. Takasawa, K. Nata, S. Kobayashi, M. Abe, N. J. Shervani, T. Ikeda, K. Nakagawa, M. Unno, S. Matsuno, et al. Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation PNAS, December 22, 2000; (2000) 240458597. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Sun, O. A. Adebanjo, B. S. Moonga, S. Corisdeo, H. K. Anandatheerthavarada, G. Biswas, T. Arakawa, Y. Hakeda, A. Koval, B. Sodam, et al. CD38/ADP-Ribosyl Cyclase: A New Role in the Regulation of Osteoclastic Bone Resorption J. Cell Biol., September 6, 1999; 146(5): 1161 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fukushi, I. Kato, S. Takasawa, T. Sasaki, B. H. Ong, M. Sato, A. Ohsaga, K. Sato, K. Shirato, H. Okamoto, et al. Identification of Cyclic ADP-ribose-dependent Mechanisms in Pancreatic Muscarinic Ca2+ Signaling Using CD38 Knockout Mice J. Biol. Chem., January 5, 2001; 276(1): 649 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Akiyama, S. Takasawa, K. Nata, S. Kobayashi, M. Abe, N. J. Shervani, T. Ikeda, K. Nakagawa, M. Unno, S. Matsuno, et al. Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation PNAS, January 2, 2001; 98(1): 48 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Mitchell, P. Pinton, A. Varadi, C. Tacchetti, E. K. Ainscow, T. Pozzan, R. Rizzuto, and G. A. Rutter Dense core secretory vesicles revealed as a dynamic Ca2+ store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera J. Cell Biol., October 1, 2001; 155(1): 41 - 52. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
