| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 4, 1873-1874, January 22, 1999
Knockout
Mouse
,
From the The phosphorylation state of three identified
neural-specific protein kinase C substrates (RC3, GAP-43/B-50, and
MARCKS) was monitored in hippocampal slices of mice lacking the
Rudolf Magnus Institute for Neurosciences,
Department of Medical Pharmacology, Unversiteitsweg 100, 3584 CG
Utrecht, The Netherlands and the ¶ Department of Molecular
Biology, The Scripps Research Institute, 10550 North Torrey Pines Road,
La Jolla, California 92037
-subtype of protein kinase C and wild-type controls by quantitative
immunoprecipitation following 32Pi
labeling. Depolarization with potassium, activation of glutamate receptors with glutamate, or direct stimulation of protein kinase C
with a phorbol ester increased RC3 phosphorylation in wild-type animals
but failed to affect RC3 phosphorylation in mice lacking the
-subtype of protein kinase C. Our results suggests the following biochemical pathway: activation of a postsynaptic (metabotropic) glutamate receptor stimulates the -subtype of protein kinase C,
which in turn phosphorylates RC3. The inability to increase RC3
phosphorylation in mice lacking the -subtype of protein kinase C by
membrane depolarization or glutamate receptor activation may contribute
to the spatial learning deficits and impaired hippocampal LTP observed
in these mice.
This article has been cited by other articles:
|
|
 |
|
  N. Higo, T. Oishi, A. Yamashita, K. Matsuda, and M. Hayashi Cell Type- and Region-specific Expression of Neurogranin mRNA in the Cerebral Cortex of the Macaque Monkey Cereb Cortex, October 1, 2004; 14(10): 1134 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Clark, T. E. Dever, J. J. Dever, P. Xu, V. Rehder, M. A. Sosa, and D. J. Baro Arthropod 5-HT2 Receptors: A Neurohormonal Receptor in Decapod Crustaceans That Displays Agonist Independent Activity Resulting from an Evolutionary Alteration to the DRY Motif J. Neurosci., March 31, 2004; 24(13): 3421 - 3435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Krucker, G. R. Siggins, R. K. McNamara, K. A. Lindsley, A. Dao, D. W. Allison, L. de Lecea, T. W. Lovenberg, J. G. Sutcliffe, and D. D. Gerendasy Targeted Disruption of RC3 Reveals a Calmodulin-Based Mechanism for Regulating Metaplasticity in the Hippocampus J. Neurosci., July 1, 2002; 22(13): 5525 - 5535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Pak, F. L. Huang, J. Li, D. Balschun, K. G. Reymann, C. Chiang, H. Westphal, and K.-P. Huang Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: A study with knockout mice PNAS, September 29, 2000; (2000) 210184697. [Abstract] [Full Text]
|
|
|
|
|
|
E. J. Weeber, C. M. Atkins, J. C. Selcher, A. W. Varga, B. Mirnikjoo, R. Paylor, M. Leitges, and J. D. Sweatt A Role for the beta Isoform of Protein Kinase C in Fear Conditioning J. Neurosci., August 15, 2000; 20(16): 5906 - 5914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Pak, F. L. Huang, J. Li, D. Balschun, K. G. Reymann, C. Chiang, H. Westphal, and K.-P. Huang Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: A study with knockout mice PNAS, October 10, 2000; 97(21): 11232 - 11237. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
