| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 4, 1875-1878, January 22, 1999
From Tularik, Inc., South San Francisco, California 94080
The specificity of the various STAT SH2 domains
for different tyrosine-containing peptides enables cytokines to
activate different signaling pathways and to induce distinct patterns
of gene expression. We show that STAT4 has a unique peptide specificity
and binds to the peptide sequence pYLPSNID (where pY represents
phosphotyrosine). This motif is found at tyrosine residue 800 in the
2 subunit of the interleukin-12 receptor and is required for
DNA binding and transcriptional activity of STAT4. Our data demonstrate
that transfection of interleukin-12 receptor 1 and 2 subunits is sufficient for STAT4 activation but not for STAT1 or STAT3 activation.
This article has been cited by other articles:
|
|
 |
|
  C. Tortorella, I. Stella, G. Piazzolla, V. Cappiello, O. Simone, A. Pisconti, and S. Antonaci Impaired Interleukin-12-Dependent T-Cell Functions During Aging: Role of Signal Transducer and Activator of Transcription 4 (STAT4) and Suppressor of Cytokine Signaling 3 (SOCS3). J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2006; 61(2): 125 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Ohyama, K Ogata, K Takeuchi, M Namisato, Y Fukutomi, F Nishimura, H Naruishi, T Ohira, K Hashimoto, T Liu, et al. Polymorphism of the 5' flanking region of the IL-12 receptor {beta}2 gene partially determines the clinical types of leprosy through impaired transcriptional activity J. Clin. Pathol., July 1, 2005; 58(7): 740 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Dumoutier, A. Tounsi, T. Michiels, C. Sommereyns, S. V. Kotenko, and J.-C. Renauld Role of the Interleukin (IL)-28 Receptor Tyrosine Residues for Antiviral and Antiproliferative Activity of IL-29/Interferon-{lambda}1: SIMILARITIES WITH TYPE I INTERFERON SIGNALING J. Biol. Chem., July 30, 2004; 279(31): 32269 - 32274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Toyoda, M. Ido, T. Hayashi, E. C. Gabazza, K. Suzuki, J. Bu, S. Tanaka, T. Nakano, H. Kamiya, J. Chipeta, et al. Impairment of IL-12-Dependent STAT4 Nuclear Translocation in a Patient with Recurrent Mycobacterium avium Infection J. Immunol., March 15, 2004; 172(6): 3905 - 3912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. O'Sullivan, H.-C. Chang, Q. Yu, and M. H. Kaplan STAT4 Is Required for Interleukin-12-induced Chromatin Remodeling of the CD25 Locus J. Biol. Chem., February 20, 2004; 279(8): 7339 - 7345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Durali, M.-G. de Goer de Herve, J. Giron-Michel, B. Azzarone, J.-F. Delfraissy, and Y. Taoufik In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment Blood, December 1, 2003; 102(12): 4084 - 4089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Chang, S. Zhang, I. Oldham, L. Naeger, T. Hoey, and M. H. Kaplan STAT4 Requires the N-terminal Domain for Efficient Phosphorylation J. Biol. Chem., August 22, 2003; 278(34): 32471 - 32477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. R. Lankford and D. M. Frucht A unique role for IL-23 in promoting cellular immunity J. Leukoc. Biol., January 1, 2003; 73(1): 49 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Cleary, W. Tu, A. Enright, T. Giffon, R. Dewaal-Malefyt, K. Gutierrez, and D. B. Lewis Impaired Accumulation and Function of Memory CD4 T Cells in Human IL-12 Receptor {beta}1 Deficiency J. Immunol., January 1, 2003; 170(1): 597 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nishikomori, T. Usui, C.-Y. Wu, A. Morinobu, J. J. O'Shea, and W. Strober Activated STAT4 Has an Essential Role in Th1 Differentiation and Proliferation That Is Independent of Its Role in the Maintenance of IL-12R{beta}2 Chain Expression and Signaling J. Immunol., October 15, 2002; 169(8): 4388 - 4398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Parham, M. Chirica, J. Timans, E. Vaisberg, M. Travis, J. Cheung, S. Pflanz, R. Zhang, K. P. Singh, F. Vega, et al. A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12R{beta}1 and a Novel Cytokine Receptor Subunit, IL-23R J. Immunol., June 1, 2002; 168(11): 5699 - 5708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Lawless, S. Zhang, O. N. Ozes, H. A. Bruns, I. Oldham, T. Hoey, M. J. Grusby, and M. H. Kaplan Stat4 Regulates Multiple Components of IFN-{gamma}-Inducing Signaling Pathways J. Immunol., December 15, 2000; 165(12): 6803 - 6808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Murphy, E. D. Geissal, J. D. Farrar, and K. M. Murphy Role of the Stat4 N Domain in Receptor Proximal Tyrosine Phosphorylation Mol. Cell. Biol., October 1, 2000; 20(19): 7121 - 7131. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Gollob, K. G. Veenstra, H. Jyonouchi, A. M. Kelly, P. Ferrieri, D. J. Panka, F. Altare, C. Fieschi, J.-L. Casanova, D. A. Frank, et al. Impairment of STAT Activation by IL-12 in a Patient with Atypical Mycobacterial and Staphylococcal Infections J. Immunol., October 1, 2000; 165(7): 4120 - 4126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zhang and M. H. Kaplan The p38 Mitogen-Activated Protein Kinase Is Required for IL-12-Induced IFN-{gamma} Expression J. Immunol., August 1, 2000; 165(3): 1374 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Farrar, J. D. Smith, T. L. Murphy, and K. M. Murphy Recruitment of Stat4 to the Human Interferon-alpha /beta Receptor Requires Activated Stat2 J. Biol. Chem., January 28, 2000; 275(4): 2693 - 2697. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
