| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 4, 2009-2013, January 22, 1999
From the Institut Cochin de Génétique
Moléculaire, U.129 INSERM Unité de Recherches en
Physiologie et Pathologie Génétiques et Moléculaires,
75014 Paris, France
In the liver, transcription of several genes
encoding lipogenic and glycolytic enzymes, in particular the gene for
fatty acid synthase (FAS), is known to be stimulated by dietary
carbohydrates. The molecular dissection of the FAS promoter pointed out
the critical role of an E box motif, located at position 
65 with
respect to the start site of transcription, in mediating the glucose-
and insulin-dependent regulation of the gene. Upstream
stimulatory factors (USF1 and USF2) and sterol response element binding
protein 1 (SREBP1) were shown to be able to interact in
vitro with this E box. However, to date, the relative
contributions of USFs and SREBP1 ex vivo remain
controversial. To gain insight into the specific roles of these factors
in vivo, we have analyzed the glucose responsiveness of
hepatic FAS gene expression in USF1 and USF2 knock-out mice. In both
types of mouse lines, defective in either USF1 or USF2, induction of
the FAS gene by refeeding a carbohydrate-rich diet was severely
delayed, whereas expression of SREBP1 was almost normal and insulin
response unchanged. Therefore, USF transactivators, and especially
USF1/USF2 heterodimers, seem to be essential to sustain the dietary
induction of the FAS gene in the liver.
This article has been cited by other articles:
|
|
 |
|
  M. Sekiya, N. Yahagi, T. Matsuzaka, Y. Takeuchi, Y. Nakagawa, H. Takahashi, H. Okazaki, Y. Iizuka, K. Ohashi, T. Gotoda, et al. SREBP-1-independent regulation of lipogenic gene expression in adipocytes J. Lipid Res., July 1, 2007; 48(7): 1581 - 1591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Lu, Y. Zhou, K. Kaufman, R. Mott, and J.-x. Ma Rat strain-dependent susceptibility to ischemia-induced retinopathy associated with retinal vascular endothelial growth factor regulation J. Mol. Endocrinol., April 1, 2007; 38(4): 423 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Dickson, M. B. Zimmerman, K. Rahmouni, and C. D. Sigmund The -20 and -217 Promoter Variants Dominate Differential Angiotensinogen Haplotype Regulation in Angiotensinogen-Expressing Cells Hypertension, March 1, 2007; 49(3): 631 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Griffin, R. H. F. Wong, N. Pandya, and H. S. Sul Direct Interaction between USF and SREBP-1c Mediates Synergistic Activation of the Fatty-acid Synthase Promoter J. Biol. Chem., February 23, 2007; 282(8): 5453 - 5467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. van der Vleuten, A. Isaacs, A. Hijmans, C. M. van Duijn, A. F. H. Stalenhoef, and J. de Graaf The involvement of upstream stimulatory factor 1 in Dutch patients with familial combined hyperlipidemia J. Lipid Res., January 1, 2007; 48(1): 193 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. K. Bayele, H. McArdle, and S. K.S. Srai Cis and trans regulation of hepcidin expression by upstream stimulatory factor Blood, December 15, 2006; 108(13): 4237 - 4245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. da Silva Xavier, G. A. Rutter, F. Diraison, C. Andreolas, and I. Leclerc ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic {beta}-cells J. Lipid Res., November 1, 2006; 47(11): 2482 - 2491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Imagawa, S. Fujii, J. Dong, T. Furumoto, T. Kaneko, T. Zaman, Y. Satoh, H. Tsutsui, and B. E Sobel Hepatocyte Growth Factor Regulates E Box-Dependent Plasminogen Activator Inhibitor Type 1 Gene Expression in HepG2 Liver Cells Arterioscler. Thromb. Vasc. Biol., October 1, 2006; 26(10): 2407 - 2413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. J. Crusselle-Davis, K. F. Vieira, Z. Zhou, A. Anantharaman, and J. Bungert Antagonistic Regulation of {beta}-Globin Gene Expression by Helix-Loop-Helix Proteins USF and TFII-I. Mol. Cell. Biol., September 1, 2006; 26(18): 6832 - 6843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Zeggini, C. M. Damcott, R. L. Hanson, M. A. Karim, N. W. Rayner, C. J. Groves, L. J. Baier, T. C. Hale, A. T. Hattersley, G. A. Hitman, et al. Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q Diabetes, September 1, 2006; 55(9): 2541 - 2548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Dentin, P.-D. Denechaud, F. Benhamed, J. Girard, and C. Postic Hepatic Gene Regulation by Glucose and Polyunsaturated Fatty Acids: A Role for ChREBP J. Nutr., May 1, 2006; 136(5): 1145 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rada-Iglesias, O. Wallerman, C. Koch, A. Ameur, S. Enroth, G. Clelland, K. Wester, S. Wilcox, O. M. Dovey, P. D. Ellis, et al. Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays Hum. Mol. Genet., November 15, 2005; 14(22): 3435 - 3447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Naukkarinen, M. Gentile, A. Soro-Paavonen, J. Saarela, H. A. Koistinen, P. Pajukanta, M.-R. Taskinen, and L. Peltonen USF1 and dyslipidemias: converging evidence for a functional intronic variant Hum. Mol. Genet., September 1, 2005; 14(17): 2595 - 2605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Huertas-Vazquez, C. Aguilar-Salinas, A. J. Lusis, R. M. Cantor, S. Canizales-Quinteros, J. C. Lee, L. Mariana-Nunez, R.-M. L. Riba-Ramirez, A. Jokiaho, T. Tusie-Luna, et al. Familial Combined Hyperlipidemia in Mexicans: Association With Upstream Transcription Factor 1 and Linkage on Chromosome 16q24.1 Arterioscler. Thromb. Vasc. Biol., September 1, 2005; 25(9): 1985 - 1991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhu, M. Casado, S. Vaulont, and K. Sharma Role of Upstream Stimulatory Factors in Regulation of Renal Transforming Growth Factor-{beta}1 Diabetes, July 1, 2005; 54(7): 1976 - 1984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nowak, A. Helleboid-Chapman, H. Jakel, G. Martin, D. Duran-Sandoval, B. Staels, E. M. Rubin, L. A. Pennacchio, M.-R. Taskinen, J. Fruchart-Najib, et al. Insulin-Mediated Down-Regulation of Apolipoprotein A5 Gene Expression through the Phosphatidylinositol 3-Kinase Pathway: Role of Upstream Stimulatory Factor Mol. Cell. Biol., February 15, 2005; 25(4): 1537 - 1548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. E. Thomas and T. J. Thekkumkara Glucose Mediates Transcriptional Repression of the Human Angiotensin Type-1 Receptor Gene: Role for a Novel Cis-acting Element Mol. Biol. Cell, October 1, 2004; 15(10): 4347 - 4355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Putt, J. Palmen, V. Nicaud, D.-A. Tregouet, N. Tahri-Daizadeh, D. M. Flavell, S. E. Humphries, P. J. Talmud, and on behalf of the EARSII group Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II Hum. Mol. Genet., August 1, 2004; 13(15): 1587 - 1597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Weigert, K. Brodbeck, M. Sawadogo, H. U. Haring, and E. D. Schleicher Upstream Stimulatory Factor (USF) Proteins Induce Human TGF-{beta}1 Gene Activation via the Glucose-response Element-1013/-1002 in Mesangial Cells: UP-REGULATION OF USF ACTIVITY BY THE HEXOSAMINE BIOSYNTHETIC PATHWAY J. Biol. Chem., April 16, 2004; 279(16): 15908 - 15915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Hadsell, S. Bonnette, J. George, D. Torres, Y. Klementidis, S. Gao, P. M. Haney, J. Summy-Long, M. S. Soloff, A. F. Parlow, et al. Diminished Milk Synthesis in Upstream Stimulatory Factor 2 Null Mice Is Associated With Decreased Circulating Oxytocin and Decreased Mammary Gland Expression of Eukaryotic Initiation Factors 4E and 4G Mol. Endocrinol., November 1, 2003; 17(11): 2251 - 2267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. I. Rodriguez, N. Girones, and M. Fresno Cha, a Basic Helix-Loop-Helix Transcription Factor Involved in the Regulation of Upstream Stimulatory Factor Activity J. Biol. Chem., October 31, 2003; 278(44): 43135 - 43145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Latasa, M. J. Griffin, Y. S. Moon, C. Kang, and H. S. Sul Occupancy and Function of the -150 Sterol Regulatory Element and -65 E-Box in Nutritional Regulation of the Fatty Acid Synthase Gene in Living Animals Mol. Cell. Biol., August 15, 2003; 23(16): 5896 - 5907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ganz Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation Blood, August 1, 2003; 102(3): 783 - 788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Medvedev, J. Robidoux, X. Bai, W. Cao, L. M. Floering, K. W. Daniel, and S. Collins Regulation of the Uncoupling Protein-2 Gene in INS-1 beta -Cells by Oleic Acid J. Biol. Chem., November 1, 2002; 277(45): 42639 - 42644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. S. Moon, M.-J. Latasa, M. J. Griffin, and H. S. Sul Suppression of fatty acid synthase promoter by polyunsaturated fatty acids J. Lipid Res., May 1, 2002; 43(5): 691 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-P. Yang, L. A. Freeman, C. L. Knapper, M. J. A. Amar, A. Remaley, H. B. Brewer Jr., and S. Santamarina-Fojo The E-box motif in the proximal ABCA1 promoter mediates transcriptional repression of the ABCA1 gene J. Lipid Res., February 1, 2002; 43(2): 297 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Smih, P. Rouet, S. Lucas, A. Mairal, C. Sengenes, M. Lafontan, S. Vaulont, M. Casado, and D. Langin Transcriptional Regulation of Adipocyte Hormone-Sensitive Lipase by Glucose Diabetes, February 1, 2002; 51(2): 293 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Fiebig, J. M. Hollander, and L. L. Ji Exercise Down-Regulates Hepatic Fatty Acid Synthase in Streptozotocin-Treated Rats J. Nutr., September 1, 2001; 131(9): 2252 - 2259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Krones, K. Jungermann, and T. Kietzmann Cross-Talk between the Signals Hypoxia and Glucose at the Glucose Response Element of the L-Type Pyruvate Kinase Gene Endocrinology, June 1, 2001; 142(6): 2707 - 2718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Samoylenko, U. Roth, K. Jungermann, and T. Kietzmann The upstream stimulatory factor-2a inhibits plasminogen activator inhibitor-1 gene expression by binding to a promoter element adjacent to the hypoxia-inducible factor-1 binding site Blood, May 1, 2001; 97(9): 2657 - 2666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vecchini, L. Binaglia, M. Bibeau, M. Minieri, F. Carotenuto, and P. Di Nardo Insulin deficiency and reduced expression of lipogenic enzymes in cardiomyopathic hamster J. Lipid Res., January 1, 2001; 42(1): 96 - 105. [Abstract] [Full Text]
|
|
|
|
 |
|
 M.-J. Latasa, Y. S. Moon, K.-H. Kim, and H. S. Sul Nutritional regulation of the fatty acid synthase promoter in vivo: Sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element PNAS, August 23, 2000; (2000) 180306597. [Abstract] [Full Text]
|
|
|
|
|
|
L. C. Hudgins, M. K. Hellerstein, C. E. Seidman, R. A. Neese, J. D. Tremaroli, and J. Hirsch Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects J. Lipid Res., April 1, 2000; 41(4): 595 - 604. [Abstract] [Full Text]
|
|
|
|
|
|
Y. S. Moon, M.-J. Latasa, K.-H. Kim, D. Wang, and H. S. Sul Two 5'-Regions Are Required for Nutritional and Insulin Regulation of the Fatty-acid Synthase Promoter in Transgenic Mice J. Biol. Chem., March 31, 2000; 275(14): 10121 - 10127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Sul, M.-J. Latasa, Y. Moon, and K.-H. Kim Regulation of the Fatty Acid Synthase Promoter by Insulin J. Nutr., February 1, 2000; 130(2): 315 - 315. [Abstract] [Full Text]
|
|
|
|
|
|
H. Shimano, N. Yahagi, M. Amemiya-Kudo, A. H. Hasty, J.-i. Osuga, Y. Tamura, F. Shionoiri, Y. Iizuka, K. Ohashi, K. Harada, et al. Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes J. Biol. Chem., December 10, 1999; 274(50): 35832 - 35839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-Q. Lou, M. Tannour, L. Selig, D. Thomas, A. Kahn, and M. Vasseur-Cognet Chicken Ovalbumin Upstream Promoter-Transcription Factor II, a New Partner of the Glucose Response Element of the L-type Pyruvate Kinase Gene, Acts as an Inhibitor of the Glucose Response J. Biol. Chem., October 1, 1999; 274(40): 28385 - 28394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sato, W. Miyamoto, J. Inoue, T. Terada, T. Imanaka, and M. Maeda Sterol Regulatory Element-binding Protein Negatively Regulates Microsomal Triglyceride Transfer Protein Gene Transcription J. Biol. Chem., August 27, 1999; 274(35): 24714 - 24720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Medvedev, S. K. Snedden, S. Raimbault, D. Ricquier, and S. Collins Transcriptional Regulation of the Mouse Uncoupling Protein-2 Gene. DOUBLE E-BOX MOTIF IS REQUIRED FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-gamma -DEPENDENT ACTIVATION J. Biol. Chem., March 30, 2001; 276(14): 10817 - 10823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rufo, M. Teran-Garcia, M. T. Nakamura, S.-H. Koo, H. C. Towle, and S. D. Clarke Involvement of a Unique Carbohydrate-responsive Factor in the Glucose Regulation of Rat Liver Fatty-acid Synthase Gene Transcription J. Biol. Chem., June 8, 2001; 276(24): 21969 - 21975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Jump, A. P. Thelen, and M. K. Mater Functional Interaction between Sterol Regulatory Element-binding Protein-1c, Nuclear Factor Y, and 3,5,3'-Triiodothyronine Nuclear Receptors J. Biol. Chem., September 7, 2001; 276(37): 34419 - 34427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Liang, J. Yang, J. D. Horton, R. E. Hammer, J. L. Goldstein, and M. S. Brown Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c J. Biol. Chem., March 8, 2002; 277(11): 9520 - 9528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vaulont, M. Vasseur-Cognet, and A. Kahn Glucose Regulation of Gene Transcription J. Biol. Chem., October 6, 2000; 275(41): 31555 - 31558. [Full Text] [PDF]
|
|
|
|
|
|
T. F. Osborne Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action J. Biol. Chem., October 13, 2000; 275(42): 32379 - 32382. [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Latasa, Y. S. Moon, K.-H. Kim, and H. S. Sul Nutritional regulation of the fatty acid synthase promoter in vivo: Sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element PNAS, September 12, 2000; 97(19): 10619 - 10624. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
