| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 4, 2038-2044, January 22, 1999
, and
From the Cell Biology Programme During the budding of enveloped viruses from the
plasma membrane, the lipids are not randomly incorporated into the
envelope, but virions seem to have a lipid composition different from
the host membrane. Here, we have analyzed lipid assemblies in three different viruses: fowl plague virus (FPV) from the influenza virus
family, vesicular stomatitis virus (VSV), and Semliki Forest virus
(SFV). Analysis of detergent extractability of proteins, cholesterol,
phosphoglycerolipids, and sphingomyelin in virions showed that FPV
contains high amounts of detergent-insoluble complexes, whereas such
complexes are largely absent from VSV or SFV. Cholesterol depletion
from the viral envelope by methyl- Structural Biology
Programme, European Molecular Biology Laboratory, Postfach 10 2209, D-69012 Heidelberg, Germany and Max-Planck-Institute for Molecular Cell
Biology and Genetics, Dresden 01307, Germany
-cyclodextrin results in increased
solubility of sphingomyelin and of the glycoproteins in the FPV
envelope. This biochemical behavior suggests that so-called raft-lipid
domains are selectively incorporated into the influenza virus envelope.
The "fluidity" of the FPV envelope, as measured by the fluorescence
polarization of diphenylhexatriene, was significantly lower than
compared with VSV or SFV. Furthermore, influenza virus hemagglutinin
incorporated into the envelope of recombinant VSV was largely
detergent-soluble, indicating the depletion of raft-lipid assemblies
from this membrane. The results provide a model for lipid selectivity
during virus budding and support the view of lipid rafts as
cholesterol-dependent, ordered domains in biological membranes.
This article has been cited by other articles:
|
|
 |
|
  B. D. Swinteck and D. S. Lyles Plasma Membrane Microdomains Containing Vesicular Stomatitis Virus M Protein Are Separate from Microdomains Containing G Protein and Nucleocapsids J. Virol., June 1, 2008; 82(11): 5536 - 5547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Biswas, S.-R. Yin, P. S. Blank, and J. Zimmerberg Cholesterol Promotes Hemifusion and Pore Widening in Membrane Fusion Induced by Influenza Hemagglutinin J. Gen. Physiol., May 1, 2008; 131(5): 503 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Bobardt, G. Cheng, L. de Witte, S. Selvarajah, U. Chatterji, B. E. Sanders-Beer, T. B. H. Geijtenbeek, F. V. Chisari, and P. A. Gallay Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virus PNAS, April 8, 2008; 105(14): 5525 - 5530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Barman and D. P. Nayak Lipid Raft Disruption by Cholesterol Depletion Enhances Influenza A Virus Budding from MDCK Cells J. Virol., November 15, 2007; 81(22): 12169 - 12178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Hess, T. J. Gould, M. V. Gudheti, S. A. Maas, K. D. Mills, and J. Zimmerberg Dynamic clustered distribution of hemagglutinin resolved at 40 nm in living cell membranes discriminates between raft theories PNAS, October 30, 2007; 104(44): 17370 - 17375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Kueng, V. M. Leb, D. Haiderer, G. Raposo, C. Thery, S. V. Derdak, K. G. Schmetterer, A. Neunkirchner, C. Sillaber, B. Seed, et al. General Strategy for Decoration of Enveloped Viruses with Functionally Active Lipid-Modified Cytokines J. Virol., August 15, 2007; 81(16): 8666 - 8676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Chen, G. P. Leser, E. Morita, and R. A. Lamb Influenza Virus Hemagglutinin and Neuraminidase, but Not the Matrix Protein, Are Required for Assembly and Budding of Plasmid-Derived Virus-Like Particles J. Virol., July 1, 2007; 81(13): 7111 - 7123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Imhoff, V. von Messling, G. Herrler, and L. Haas Canine Distemper Virus Infection Requires Cholesterol in the Viral Envelope J. Virol., April 15, 2007; 81(8): 4158 - 4165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Fleming, A. A. Kolokoltsov, R. A. Davey, J. E. Nichols, and N. J. Roberts Jr. Respiratory Syncytial Virus F Envelope Protein Associates with Lipid Rafts without a Requirement for Other Virus Proteins J. Virol., December 15, 2006; 80(24): 12160 - 12170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Wilson-Ashworth, Q. Bahm, J. Erickson, A. Shinkle, M. P. Vu, D. Woodbury, and J. D. Bell Differential Detection of Phospholipid Fluidity, Order, and Spacing by Fluorescence Spectroscopy of Bis-pyrene, Prodan, Nystatin, and Merocyanine 540 Biophys. J., December 1, 2006; 91(11): 4091 - 4101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bukrinsky and D. Sviridov Human immunodeficiency virus infection and macrophage cholesterol metabolism. J. Leukoc. Biol., November 1, 2006; 80(5): 1044 - 1051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. P. Oomens, K. P. Bevis, and G. W. Wertz The Cytoplasmic Tail of the Human Respiratory Syncytial Virus F Protein Plays Critical Roles in Cellular Localization of the F Protein and Infectious Progeny Production J. Virol., November 1, 2006; 80(21): 10465 - 10477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Kiessling, J. M. Crane, and L. K. Tamm Transbilayer Effects of Raft-Like Lipid Domains in Asymmetric Planar Bilayers Measured by Single Molecule Tracking Biophys. J., November 1, 2006; 91(9): 3313 - 3326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Corcoran, J. Salsman, R. de Antueno, A. Touhami, M. H. Jericho, E. K. Clancy, and R. Duncan The p14 Fusion-associated Small Transmembrane (FAST) Protein Effects Membrane Fusion from a Subset of Membrane Microdomains J. Biol. Chem., October 20, 2006; 281(42): 31778 - 31789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Derdak, H. J. Kueng, V. M. Leb, A. Neunkirchner, K. G. Schmetterer, E. Bielek, O. Majdic, W. Knapp, B. Seed, and W. F. Pickl Direct stimulation of T lymphocytes by immunosomes: Virus-like particles decorated with T cell receptor/CD3 ligands plus costimulatory molecules PNAS, August 29, 2006; 103(35): 13144 - 13149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. McCown and A. Pekosz Distinct domains of the influenza a virus m2 protein cytoplasmic tail mediate binding to the m1 protein and facilitate infectious virus production. J. Virol., August 1, 2006; 80(16): 8178 - 8189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Marjuki, M. I. Alam, C. Ehrhardt, R. Wagner, O. Planz, H.-D. Klenk, S. Ludwig, and S. Pleschka Membrane Accumulation of Influenza A Virus Hemagglutinin Triggers Nuclear Export of the Viral Genome via Protein Kinase C{alpha}-mediated Activation of ERK Signaling J. Biol. Chem., June 16, 2006; 281(24): 16707 - 16715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Brugger, B. Glass, P. Haberkant, I. Leibrecht, F. T. Wieland, and H.-G. Krausslich The HIV lipidome: A raft with an unusual composition PNAS, February 21, 2006; 103(8): 2641 - 2646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. B. Thorp, J. A. Boscarino, H. L. Logan, J. T. Goletz, and T. M. Gallagher Palmitoylations on Murine Coronavirus Spike Proteins Are Essential for Virion Assembly and Infectivity J. Virol., February 1, 2006; 80(3): 1280 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Goluszko and B. Nowicki Membrane Cholesterol: a Crucial Molecule Affecting Interactions of Microbial Pathogens with Mammalian Cells Infect. Immun., December 1, 2005; 73(12): 7791 - 7796. [Full Text] [PDF]
|
|
|
|
|
|
B. J. Chen, M. Takeda, and R. A. Lamb Influenza Virus Hemagglutinin (H3 Subtype) Requires Palmitoylation of Its Cytoplasmic Tail for Assembly: M1 Proteins of Two Subtypes Differ in Their Ability To Support Assembly J. Virol., November 1, 2005; 79(21): 13673 - 13684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. del Conde, C. N. Shrimpton, P. Thiagarajan, and J. A. Lopez Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation Blood, September 1, 2005; 106(5): 1604 - 1611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Choi, H. Aizaki, and M. M. C. Lai Murine Coronavirus Requires Lipid Rafts for Virus Entry and Cell-Cell Fusion but Not for Virus Release J. Virol., August 1, 2005; 79(15): 9862 - 9871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Hess, M. Kumar, A. Verma, J. Farrington, A. Kenworthy, and J. Zimmerberg Quantitative electron microscopy and fluorescence spectroscopy of the membrane distribution of influenza hemagglutinin J. Cell Biol., June 20, 2005; 169(6): 965 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Brown and D. S. Lyles Pseudotypes of Vesicular Stomatitis Virus with CD4 Formed by Clustering of Membrane Microdomains during Budding J. Virol., June 1, 2005; 79(11): 7077 - 7086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wagner, A. Herwig, N. Azzouz, and H. D. Klenk Acylation-Mediated Membrane Anchoring of Avian Influenza Virus Hemagglutinin Is Essential for Fusion Pore Formation and Virus Infectivity J. Virol., May 15, 2005; 79(10): 6449 - 6458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kitagawa, H. Tani, C. K. Limn, T. M. Matsunaga, K. Moriishi, and Y. Matsuura Ligand-Directed Gene Targeting to Mammalian Cells by Pseudotype Baculoviruses J. Virol., March 15, 2005; 79(6): 3639 - 3652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hoenen, V. Volchkov, L. Kolesnikova, E. Mittler, J. Timmins, M. Ottmann, O. Reynard, S. Becker, and W. Weissenhorn VP40 Octamers Are Essential for Ebola Virus Replication J. Virol., February 1, 2005; 79(3): 1898 - 1905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Triantafilou and M. Triantafilou Coxsackievirus B4-Induced Cytokine Production in Pancreatic Cells Is Mediated through Toll-Like Receptor 4 J. Virol., October 15, 2004; 78(20): 11313 - 11320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Campbell, K. Gaus, R. Bittman, W. Jessup, S. Crowe, and J. Mak The Raft-Promoting Property of Virion-Associated Cholesterol, but Not the Presence of Virion-Associated Brij 98 Rafts, Is a Determinant of Human Immunodeficiency Virus Type 1 Infectivity J. Virol., October 1, 2004; 78(19): 10556 - 10565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Licata, R. F. Johnson, Z. Han, and R. N. Harty Contribution of Ebola Virus Glycoprotein, Nucleoprotein, and VP24 to Budding of VP40 Virus-Like Particles J. Virol., July 15, 2004; 78(14): 7344 - 7351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Sadler and N. D. Jacobs Stimulation of Xenopus laevis Oocyte Maturation by Methyl-{beta}-Cyclodextrin Biol Reprod, June 1, 2004; 70(6): 1685 - 1692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Barman, L. Adhikary, A. K. Chakrabarti, C. Bernas, Y. Kawaoka, and D. P. Nayak Role of Transmembrane Domain and Cytoplasmic Tail Amino Acid Sequences of Influenza A Virus Neuraminidase in Raft Association and Virus Budding J. Virol., May 15, 2004; 78(10): 5258 - 5269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Favoreel, T. C. Mettenleiter, and H. J. Nauwynck Copatching and Lipid Raft Association of Different Viral Glycoproteins Expressed on the Surfaces of Pseudorabies Virus-Infected Cells J. Virol., May 15, 2004; 78(10): 5279 - 5287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gao, H. Aizaki, J.-W. He, and M. M. C. Lai Interactions between Viral Nonstructural Proteins and Host Protein hVAP-33 Mediate the Formation of Hepatitis C Virus RNA Replication Complex on Lipid Raft J. Virol., April 1, 2004; 78(7): 3480 - 3488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Irie, J. M. Licata, J. P. McGettigan, M. J. Schnell, and R. N. Harty Budding of PPxY-Containing Rhabdoviruses Is Not Dependent on Host Proteins TGS101 and VPS4A J. Virol., March 15, 2004; 78(6): 2657 - 2665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Stuven, A. Porat, F. Shimron, E. Fass, D. Kaloyanova, B. Brugger, F. T. Wieland, Z. Elazar, and J. B. Helms Intra-Golgi Protein Transport Depends on a Cholesterol Balance in the Lipid Membrane J. Biol. Chem., December 26, 2003; 278(52): 53112 - 53122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Panchal, G. Ruthel, T. A. Kenny, G. H. Kallstrom, D. Lane, S. S. Badie, L. Li, S. Bavari, and M. J. Aman In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding PNAS, December 23, 2003; 100(26): 15936 - 15941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Dolganiuc, L. McGinnes, E. J. Luna, and T. G. Morrison Role of the Cytoplasmic Domain of the Newcastle Disease Virus Fusion Protein in Association with Lipid Rafts J. Virol., December 15, 2003; 77(24): 12968 - 12979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Feng, N. Vander Heyden, and L. Ratner Alpha Interferon Inhibits Human T-Cell Leukemia Virus Type 1 Assembly by Preventing Gag Interaction with Rafts J. Virol., December 15, 2003; 77(24): 13389 - 13395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Takeda, G. P. Leser, C. J. Russell, and R. A. Lamb Inaugural Article: Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion PNAS, December 9, 2003; 100(25): 14610 - 14617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Sun and G. R. Whittaker Role for Influenza Virus Envelope Cholesterol in Virus Entry and Infection J. Virol., December 1, 2003; 77(23): 12543 - 12551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. C. Bender, J. C. Whitbeck, M. Ponce de Leon, H. Lou, R. J. Eisenberg, and G. H. Cohen Specific Association of Glycoprotein B with Lipid Rafts during Herpes Simplex Virus Entry J. Virol., September 1, 2003; 77(17): 9542 - 9552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Watarai, S. Kim, J. Erdenebaatar, S.-i. Makino, M. Horiuchi, T. Shirahata, S. Sakaguchi, and S. Katamine Cellular Prion Protein Promotes Brucella Infection into Macrophages J. Exp. Med., July 7, 2003; 198(1): 5 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Chazal and D. Gerlier Virus Entry, Assembly, Budding, and Membrane Rafts Microbiol. Mol. Biol. Rev., June 1, 2003; 67(2): 226 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. X. Zhang, Y. Han, and G. W. Blissard Palmitoylation of the Autographa californica Multicapsid Nucleopolyhedrovirus Envelope Glycoprotein GP64: Mapping, Functional Studies, and Lipid Rafts J. Virol., June 1, 2003; 77(11): 6265 - 6273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Browne, B. Bruun, A. Whiteley, and T. Minson Analysis of the role of the membrane-spanning and cytoplasmic tail domains of herpes simplex virus type 1 glycoprotein D in membrane fusion J. Gen. Virol., May 1, 2003; 84(5): 1085 - 1089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. G. Briggs, T. Wilk, and S. D. Fuller Do lipid rafts mediate virus assembly and pseudotyping? J. Gen. Virol., April 1, 2003; 84(4): 757 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. McCurdy and B. S. Graham Role of Plasma Membrane Lipid Microdomains in Respiratory Syncytial Virus Filament Formation J. Virol., February 1, 2003; 77(3): 1747 - 1756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ding, A. Derdowski, J.-J. Wang, and P. Spearman Independent Segregation of Human Immunodeficiency Virus Type 1 Gag Protein Complexes and Lipid Rafts J. Virol., February 1, 2003; 77(3): 1916 - 1926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Favoreel, G. R. Van de Walle, H. J. Nauwynck, and M. B. Pensaert Virus complement evasion strategies J. Gen. Virol., January 1, 2003; 84(1): 1 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Gargalovic and L. Dory Caveolins and macrophage lipid metabolism J. Lipid Res., January 1, 2003; 44(1): 11 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. K.-W. Hui and D. P. Nayak Role of G protein and protein kinase signalling in influenza virus budding in MDCK cells J. Gen. Virol., December 1, 2002; 83(12): 3055 - 3066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Li, C. Yang, S. Tong, A. Weidmann, and R. W. Compans Palmitoylation of the Murine Leukemia Virus Envelope Protein Is Critical for Lipid Raft Association and Surface Expression J. Virol., October 25, 2002; 76(23): 11845 - 11852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. I. Michonova-Alexova and I. P. Sugar Component and State Separation in DMPC/DSPC Lipid Bilayers: A Monte Carlo Simulation Study Biophys. J., October 1, 2002; 83(4): 1820 - 1833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Guyader, E. Kiyokawa, L. Abrami, P. Turelli, and D. Trono Role for Human Immunodeficiency Virus Type 1 Membrane Cholesterol in Viral Internalization J. Virol., September 11, 2002; 76(20): 10356 - 10364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Sieczkarski and G. R. Whittaker Influenza Virus Can Enter and Infect Cells in the Absence of Clathrin-Mediated Endocytosis J. Virol., September 11, 2002; 76(20): 10455 - 10464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Watarai, S.-i. Makino, M. Michikawa, K. Yanagisawa, S. Murakami, and T. Shirahata Macrophage Plasma Membrane Cholesterol Contributes to Brucella abortus Infection of Mice Infect. Immun., September 1, 2002; 70(9): 4818 - 4825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Llano, T. Kelly, M. Vanegas, M. Peretz, T. E. Peterson, R. D. Simari, and E. M. Poeschla Blockade of Human Immunodeficiency Virus Type 1 Expression by Caveolin-1 J. Virol., August 12, 2002; 76(18): 9152 - 9164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Stuart, H. E. Eustace, T. A. McKee, and T. D. K. Brown A Novel Cell Entry Pathway for a DAF-Using Human Enterovirus Is Dependent on Lipid Rafts J. Virol., August 12, 2002; 76(18): 9307 - 9322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Grassme, J. Bock, J. Kun, and E. Gulbins Clustering of CD40 Ligand Is Required to Form a Functional Contact with CD40 J. Biol. Chem., August 9, 2002; 277(33): 30289 - 30299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Brown, H. W. McL. Rixon, and R. J. Sugrue Respiratory syncytial virus assembly occurs in GM1-rich regions of the host-cell membrane and alters the cellular distribution of tyrosine phosphorylated caveolin-1 J. Gen. Virol., August 1, 200 |
