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J Biol Chem, Vol. 274, Issue 40, 28067-28070, October 1, 1999

COMMUNICATION
B-myb Is Required for Inner Cell Mass Formation at an Early Stage of Development

Yasunori TanakaDagger , Nikos P. PatestosDagger , Toshio MaekawaDagger **, and Shunsuke IshiiDagger **

From the Dagger  Laboratory of Molecular Genetics, RIKEN Tsukuba Life Sciences Center, and the ** Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Agency, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan

The myb gene family has three members, c-myb, A-myb, and B-myb, which have distinct expression patterns. Analyses of c-myb and A-myb mutant mice have indicated that c-myb and A-myb are important for hematopoiesis and spermatogenesis, respectively. However, there has been no evidence for a role for B-myb in development. To examine the role of B-myb in development, we generated B-myb-deficient mice by gene targeting. Although the heterozygous mutants were healthy, the homozygous mutants died at an early stage of development, around E4.5-E6.5. In vitro culture of blastocyst indicated that B-myb is required for inner cell mass formation. Consistent with the important role of B-myb in early embryonic development, only B-myb among myb family members was expressed in embryonic stem cells. These results indicate that each of the three members of the myb gene family plays a distinct role during development.

Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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