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J Biol Chem, Vol. 274, Issue 41, 29420-29425, October 8, 1999

A Novel Sulfonylurea Receptor Family Member Expressed in the Embryonic Drosophila Dorsal Vessel and Tracheal System

Igor NasonkinDagger , Ayfer AlikasifogluDagger , Catherine Ambroseparallel , Paula Cahillparallel , Michael Chengparallel , Agit Sarniakparallel , Marie Eganparallel , and Pamela M. ThomasDagger

From the Dagger  Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan 48109-0646 and the parallel  Department of Pediatrics, Yale University, New Haven, Connecticut 06520

Sulfonylurea receptors (SURx) are required subunits of the ATP-sensitive potassium channel. SURx alone is electrophysiologically inert. However, when SURx is combined with an inward rectifier Kir6.2 subunit, ATP-sensitive potassium channel activity is generated. We report the identification, characterization, and localization of Dsur, a novel Drosophila gene that is highly related to the vertebrate SUR family. The Dsur coding sequence contains structural features characteristic of the ABC transporter family and, in addition, harbors 1.7 kilobases of a distinctive sequence that does not share homology with any known gene. When Dsur alone is expressed in Xenopus oocytes glibenclamide-sensitive potassium channel activity occurs. During Drosophila embryogenesis, the Dsur gene is specifically expressed in the developing tracheal system and dorsal vessel. Studies of the Drosophila genome support that only a single Dsur gene is present. Our data reveal conservation of glibenclamide-sensitive potassium channels in Drosophila and suggest that Dsur may play an important role during Drosophila embryogenesis. The lack of gene duplication in the Drosophila system provides a unique opportunity for functional studies of SUR using a genetic approach.

Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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