|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 41, 29439-29452, October 8, 1999
From the Epithelial cell differentiation is tightly
controlled by distinct sets of transcription factors that regulate the
expression of stage-specific genes. We recently isolated the first
epithelium-specific Ets transcription factor (ESE-1). Here we describe
the characterization of ESE-2, a second epithelium-restricted
ESE-1-related Ets factor. Like ESE-1, ESE-2 is induced during
keratinocyte differentiation. However, whereas ESE-1 is expressed in
the majority of epithelial cell types, ESE-2 expression is restricted
to differentiated keratinocytes and glandular epithelium such as
salivary gland, prostate, mammary gland, and kidney. In contrast to
ESE-1, full-length ESE-2 binds poorly to DNA due to the presence of a
negative regulatory domain at the amino terminus. Furthermore, although
ESE-1 and the amino-terminally deleted ESE-2 bind with similar affinity
to the canonical E74 Ets site, ESE-2 and ESE-1 differ strikingly in
their relative affinity toward binding sites in the c-MET and PSMA
promoters. Similarly, ESE-1 and ESE-2 drastically differ in their
ability to transactivate epithelium-specific promoters. Thus, ESE-2,
but not ESE-1, transactivates the parotid gland-specific PSP promoter and the prostate-specific PSA promoter. In contrast, ESE-1
transactivates the keratinocyte-specific SPRR2A promoter Ets site and
the prostate-specific PSMA promoter significantly better than ESE-2.
Our results demonstrate the existence of a unique class of related
epithelium-specific Ets factors with distinct functions in epithelial
cell gene regulation.
Characterization of ESE-2, a Novel ESE-1-related Ets
Transcription Factor That Is Restricted to Glandular Epithelium and
Differentiated Keratinocytes
,§,,,,,,,,
,, and
New England Baptist Bone and Joint
Institute, Beth Israel Deaconess Medical Center, and Harvard
Medical School, Boston, Massachusetts 02115, § Laboratory
for Molecular Oncology, Center for Human Genetics, University of
Leuven and Flanders Interuniversity Institute for Biotechnology,
Herestraat 49, B-3000 Leuven, Belgium, Human Genome Sciences,
Inc., Rockville, Maryland 20850, and the ** Department of Pathology,
Harvard Medical School, Boston, Massachusetts 02115
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. R. Oakes, M. J. Naylor, M.-L. Asselin-Labat, K. D. Blazek, M. Gardiner-Garden, H. N. Hilton, M. Kazlauskas, M. A. Pritchard, L. A. Chodosh, P. L. Pfeffer, et al. The Ets transcription factor Elf5 specifies mammary alveolar cell fate Genes & Dev., March 1, 2008; 22(5): 581 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Lei, R. J. Jaramillo, and K. S. Harrod Transactivation of lung lysozyme expression by Ets family member ESE-1 Am J Physiol Lung Cell Mol Physiol, November 1, 2007; 293(5): L1359 - L1368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Gu, L. F. Zerbini, H. H. Otu, M. Bhasin, Q. Yang, M. G. Joseph, F. Grall, T. Onatunde, R. G. Correa, and T. A. Libermann Reduced PDEF Expression Increases Invasion and Expression of Mesenchymal Genes in Prostate Cancer Cells Cancer Res., May 1, 2007; 67(9): 4219 - 4226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Kopp, P. J. Wilder, M. Desler, L. Kinarsky, and A. Rizzino Different Domains of the Transcription Factor ELF3 Are Required in a Promoter-specific Manner and Multiple Domains Control Its Binding to DNA J. Biol. Chem., February 2, 2007; 282(5): 3027 - 3041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Harris, P. M. Stanford, K. Sutherland, S. R. Oakes, M. J. Naylor, F. G. Robertson, K. D. Blazek, M. Kazlauskas, H. N. Hilton, S. Wittlin, et al. Socs2 and Elf5 Mediate Prolactin-Induced Mammary Gland Development Mol. Endocrinol., May 1, 2006; 20(5): 1177 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Appel, A. Bringmann, F. Grunebach, M. M. Weck, J. Bauer, and P. Brossart Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs Blood, April 15, 2006; 107(8): 3265 - 3270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Donnison, A. Beaton, H. W. Davey, R. Broadhurst, P. L'Huillier, and P. L. Pfeffer Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning Development, May 15, 2005; 132(10): 2299 - 2308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Hollenhorst, D. A. Jones, and B. J. Graves Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors Nucleic Acids Res., October 21, 2004; 32(18): 5693 - 5702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Prescott, K. S. N. Koto, M. Singh, and A. Gutierrez-Hartmann The ETS Transcription Factor ESE-1 Transforms MCF-12A Human Mammary Epithelial Cells via a Novel Cytoplasmic Mechanism Mol. Cell. Biol., June 15, 2004; 24(12): 5548 - 5564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wang, R. Fang, J.-Y. Cho, T. A. Libermann, and P. Oettgen Positive and Negative Modulation of the Transcriptional Activity of the ETS Factor ESE-1 through Interaction with p300, CREB-binding Protein, and Ku 70/86 J. Biol. Chem., June 11, 2004; 279(24): 25241 - 25250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Kopp, P. J. Wilder, M. Desler, J.-H. Kim, J. Hou, T. Nowling, and A. Rizzino Unique and Selective Effects of Five Ets Family Members, Elf3, Ets1, Ets2, PEA3, and PU.1, on the Promoter of the Type II Transforming Growth Factor-{beta} Receptor Gene J. Biol. Chem., May 7, 2004; 279(19): 19407 - 19420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Heinlein and C. Chang Androgen Receptor in Prostate Cancer Endocr. Rev., April 1, 2004; 25(2): 276 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Elvert, A. Kappel, R. Heidenreich, U. Englmeier, S. Lanz, T. Acker, M. Rauter, K. Plate, M. Sieweke, G. Breier, et al. Cooperative Interaction of Hypoxia-inducible Factor-2alpha (HIF-2alpha ) and Ets-1 in the Transcriptional Activation of Vascular Endothelial Growth Factor Receptor-2 (Flk-1) J. Biol. Chem., February 21, 2003; 278(9): 7520 - 7530. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Silverman, R. M. Baron, L. J. Palmer, L. Le, A. Hallock, V. Subramaniam, R. J. Riese, M. D. McKenna, X. Gu, T. A. Libermann, et al. Constitutive and Cytokine-Induced Expression of the ETS Transcription Factor ESE-3 in the Lung Am. J. Respir. Cell Mol. Biol., December 1, 2002; 27(6): 697 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. I. Jobling, Z. Fang, D. Koleski, and M. J. Tymms Expression of the ETS Transcription Factor ELF3 in the Retinal Pigment Epithelium Invest. Ophthalmol. Vis. Sci., November 1, 2002; 43(11): 3530 - 3537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Baron, L. J. Palmer, K. Tantisira, S. Gabriel, L. A. Sonna, L. Le, A. Hallock, T. A. Libermann, J. M. Drazen, S. T. Weiss, et al. DNA Sequence Variants in Epithelium-Specific ETS-2 and ETS-3 Are Not Associated with Asthma Am. J. Respir. Crit. Care Med., October 1, 2002; 166(7): 927 - 932. [Abstract] [Full Text]
|
|
|
|
|
|
J.-H. Kim, P. J. Wilder, J. Hou, T. Nowling, and A. Rizzino Activation of the Murine Type II Transforming Growth Factor-beta Receptor Gene. UP-REGULATION AND FUNCTION OF THE TRANSCRIPTION FACTOR Elf-3/Ert/Esx/Ese-1 J. Biol. Chem., May 10, 2002; 277(20): 17520 - 17530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Cinar, K. S. Koeneman, M. Edlund, G. S. Prins, H. E. Zhau, and L. W. K. Chung Androgen Receptor Mediates the Reduced Tumor Growth, Enhanced Androgen Responsiveness, and Selected Target Gene Transactivation in a Human Prostate Cancer Cell Line Cancer Res., October 1, 2001; 61(19): 7310 - 7317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sinha, L. Degenstein, C. Copenhaver, and E. Fuchs Defining the Regulatory Factors Required for Epidermal Gene Expression Mol. Cell. Biol., April 1, 2000; 20(7): 2543 - 2555. [Abstract] [Full Text]
|
|
|
|
|
|
K. Kas, E. Finger, F. Grall, X. Gu, Y. Akbarali, J. Boltax, A. Weiss, P. Oettgen, R. Kapeller, and T. A. Libermann ESE-3, a Novel Member of an Epithelium-specific Ets Transcription Factor Subfamily, Demonstrates Different Target Gene Specificity from ESE-1 J. Biol. Chem., January 28, 2000; 275(4): 2986 - 2998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Oettgen, E. Finger, Z. Sun, Y. Akbarali, U. Thamrongsak, J. Boltax, F. Grall, A. Dube, A. Weiss, L. Brown, et al. PDEF, a Novel Prostate Epithelium-specific Ets Transcription Factor, Interacts with the Androgen Receptor and Activates Prostate-specific Antigen Gene Expression J. Biol. Chem., January 14, 2000; 275(2): 1216 - 1225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rudders, J. Gaspar, R. Madore, C. Voland, F. Grall, A. Patel, A. Pellacani, M. A. Perrella, T. A. Libermann, and P. Oettgen ESE-1 Is a Novel Transcriptional Mediator of Inflammation That Interacts with NF-kappa B to Regulate the Inducible Nitric-oxide Synthase Gene J. Biol. Chem., January 26, 2001; 276(5): 3302 - 3309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Gu, B.-H. Shin, Y. Akbarali, A. Weiss, J. Boltax, P. Oettgen, and T. A. Libermann Tel-2 Is a Novel Transcriptional Repressor Related to the Ets Factor Tel/ETV-6 J. Biol. Chem., March 16, 2001; 276(12): 9421 - 9436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tugores, J. Le, I. Sorokina, A. J. Snijders, M. Duyao, P. S. Reddy, L. Carlee, M. Ronshaugen, A. Mushegian, T. Watanaskul, et al. The Epithelium-specific ETS Protein EHF/ESE-3 Is a Context-dependent Transcriptional Repressor Downstream of MAPK Signaling Cascades J. Biol. Chem., June 1, 2001; 276(23): 20397 - 20406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Sugihara, E. I. Kudryavtseva, V. Kumar, J. J. Horridge, and B. Andersen The POU Domain Factor Skin-1a Represses the Keratin 14 Promoter Independent of DNA Binding. A POSSIBLE ROLE FOR INTERACTIONS BETWEEN Skn-1a AND CREB-BINDING PROTEIN/p300 J. Biol. Chem., August 24, 2001; 276(35): 33036 - 33044. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |