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J Biol Chem, Vol. 274, Issue 41, 29564-29567, October 8, 1999

The TFB4 Subunit of Yeast TFIIH Is Required for Both Nucleotide Excision Repair and RNA Polymerase II Transcription

From the Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9072

The N-degron strategy has been used to generate a yeast strain harboring a temperature-sensitive allele of TFB4 (tfb4^td), the gene that encodes the 37-kDa subunit of the transcription/repair factor TFIIH. The tfb4^td strain was sensitive to UV radiation and is defective in nucleotide excision repair in vitro. The mutant strain was also found to be an inositol auxotroph due at least in part to an inability to properly induce expression of the INO1 gene. These results indicate that like other subunits of TFIIH, Tfb4 is required for both RNA polymerase II transcription and DNA repair.

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