| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 42, 29672-29676, October 15, 1999
but Not by
12-O-Tetradecanoylphorbol-13-Acetate
From the Hormel Institute, University of Minnesota,
Austin, Minnesota 55912
Signal transduction via
mitogen-activated protein kinase pathways plays a key role in a variety
of cellular responses, including cell proliferation, differentiation,
tumor promotion, and cell death. c-Jun N-terminal kinases (JNKs) are
identified as members of the mitogen-activated protein kinase family
and are known to phosphorylate and activate several transcription
factors, including c-Jun, ATF, and Elk-1. However, the role of JNK
activation in tumor promotion is not yet defined. Because previous
studies have indicated that exposure of JB6 Cl 41 cells to either
12-O-tetradecanoylphorbol-13-acetate (TPA) or tumor
necrosis factor-
(TNF-) results in cell transformation, we
investigated the role of JNKs in this biological process by using
dominant negative JNK1 and the cell transformation model JB6 Cl 41 cells. Incubation of Cl 41 cells with TNF- led to cell transformation and activation of JNKs. Introduction of the dominant negative mutant of JNK1 into JB6 Cl 41 cells specifically
inhibited TNF--induced activation of JNKs, but not Erks and p38
kinases. Most importantly, expressing dominant negative mutant
JNK1 inhibited TNF--induced cell transformation but not
TPA-induced cell transformation. Our results directly demonstrated for
the first time that JNK activation is required for TNF-- but not
TPA-induced cell transformation.
This article has been cited by other articles:
|
|
 |
|
  D. Zhang, J. Li, L. Song, W. Ouyang, J. Gao, and C. Huang A JNK1/AP-1-Dependent, COX-2 Induction Is Implicated in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Transformation through Regulating Cell Cycle Progression Mol. Cancer Res., January 1, 2008; 6(1): 165 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yang, B. J. Misner, R. J. Chiu, and F. L. Meyskens Jr Redox effector factor-1, combined with reactive oxygen species, plays an important role in the transformation of JB6 cells Carcinogenesis, November 1, 2007; 28(11): 2382 - 2390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ouyang, Y. Hu, J. Li, M. Ding, Y. Lu, D. Zhang, Y. Yan, L. Song, Q. Qu, D. Desai, et al. Direct evidence for the critical role of NFAT3 in benzo[a]pyrene diol-epoxide-induced cell transformation through mediation of inflammatory cytokine TNF induction in mouse epidermal Cl41 cells Carcinogenesis, October 1, 2007; 28(10): 2218 - 2226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-M. Oh, F. Zhu, Y.-Y. Cho, K. W. Lee, B. S. Kang, H.-G. Kim, T. Zykova, A. M. Bode, and Z. Dong T-Lymphokine-Activated Killer Cell-Originated Protein Kinase Functions as a Positive Regulator of c-Jun-NH2-Kinase 1 Signaling and H-Ras-Induced Cell Transformation Cancer Res., June 1, 2007; 67(11): 5186 - 5194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, Y. Zhang, H. Li, Z. Xu, R. M. Santella, and I. B. Weinstein Hint1 Inhibits Growth and Activator Protein-1 Activity in Human Colon Cancer Cells Cancer Res., May 15, 2007; 67(10): 4700 - 4708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yan, J. Li, W. Ouyang, Q. Ma, Y. Hu, D. Zhang, J. Ding, Q. Qu, K. Subbaramaiah, and C. Huang NFAT3 is specifically required for TNF-{alpha}-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells J. Cell Sci., July 15, 2006; 119(14): 2985 - 2994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lu, W. Ouyang, and C. Huang Inflammation, a Key Event in Cancer Development Mol. Cancer Res., April 1, 2006; 4(4): 221 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hu, H. Nakano, H. Sakurai, and N. H. Colburn Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-{kappa}B activation and transformation in resistant JB6 cells Carcinogenesis, October 1, 2004; 25(10): 1991 - 2003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, H. Chen, M.-S. Tang, X. Shi, S. Amin, D. Desai, M. Costa, and C. Huang PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells J. Cell Biol., April 12, 2004; 165(1): 77 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-X. Hou, K. Kai, J.-J. Li, S. Lin, N. Terahara, M. Wakamatsu, M. Fujii, M. R. Young, and N. Colburn Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms Carcinogenesis, January 1, 2004; 25(1): 29 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Dong and A. M. Bode Dialogue Between ERKs and JNKs: Friendly or Antagonistic? Mol. Interv., September 1, 2003; 3(6): 306 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Gao, A. Zuberi, M. J. Quon, Z. Dong, and J. Ye Aspirin Inhibits Serine Phosphorylation of Insulin Receptor Substrate 1 in Tumor Necrosis Factor-treated Cells through Targeting Multiple Serine Kinases J. Biol. Chem., June 27, 2003; 278(27): 24944 - 24950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Bode and Z. Dong Mitogen-Activated Protein Kinase Activation in UV-Induced Signal Transduction Sci. Signal., January 28, 2003; 2003(167): re2 - re2. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-B. She, W.-Y. Ma, S. Zhong, and Z. Dong Activation of JNK1, RSK2, and MSK1 Is Involved in Serine 112 Phosphorylation of Bad by Ultraviolet B Radiation J. Biol. Chem., June 28, 2002; 277(27): 24039 - 24048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Dong and J. L. Cmarik Harvesting Cells Under Anchorage-Independent Cell Transformation Conditions for Biochemical Analyses Sci. Signal., April 30, 2002; 2002(130): pl7 - pl7. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-B. She, N. Chen, A. M. Bode, R. A. Flavell, and Z. Dong Deficiency of c-Jun-NH2-terminal Kinase-1 in Mice Enhances Skin Tumor Development by 12-O-Tetradecanoylphorbol-13-Acetate Cancer Res., March 1, 2002; 62(5): 1343 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Liu, A. Bode, W.-Y. Ma, S. Sang, C.-T. Ho, and Z. Dong Two Novel Glycosides from the Fruits of Morinda Citrifolia (Noni) Inhibit AP-1 Transactivation and Cell Transformation in the Mouse Epidermal JB6 Cell Line Cancer Res., August 1, 2001; 61(15): 5749 - 5756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Liu, D. M. Bibus, A. M. Bode, W.-Y. Ma, R. T. Holman, and Z. Dong Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells PNAS, June 19, 2001; 98(13): 7510 - 7515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Chen, M. Nomura, Q.-B. She, W.-Y. Ma, A. M. Bode, L. Wang, R. A. Flavell, and Z. Dong Suppression of Skin Tumorigenesis in c-Jun NH2-Terminal Kinase-2-Deficient Mice Cancer Res., May 1, 2001; 61(10): 3908 - 3912. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Liu, E. Duysen, A. L. Yaktine, A. Au, W. Wang, and D. F. Birt Dietary energy restriction inhibits ERK but not JNK or p38 activity in the epidermis of SENCAR mice Carcinogenesis, April 1, 2001; 22(4): 607 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-B. She, A. M. Bode, W.-Y. Ma, N.-Y. Chen, and Z. Dong Resveratrol-induced Activation of p53 and Apoptosis Is Mediated by Extracellular- Signal-regulated Protein Kinases and p38 Kinase Cancer Res., February 1, 2001; 61(4): 1604 - 1610. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. C. Bancroft, Z. Chen, G. Dong, J. B. Sunwoo, N. Yeh, C. Park, and C. Van Waes Coexpression of Proangiogenic Factors IL-8 and VEGF by Human Head and Neck Squamous Cell Carcinoma Involves Coactivation by MEK-MAPK and IKK-NF-{{kappa}}B Signal Pathways Clin. Cancer Res., February 1, 2001; 7(2): 435 - 442. [Abstract] [Full Text]
|
|
|
|
|
|
S. Mandlekar, R. Yu, T.-H. Tan, and A.-N. T. Kong Activation of Caspase-3 and c-Jun NH2-terminal Kinase-1 Signaling Pathways in Tamoxifen-induced Apoptosis of Human Breast Cancer Cells Cancer Res., November 1, 2000; 60(21): 5995 - 6000. [Abstract] [Full Text]
|
|
|
|
|
|
A. Murakami, K. Kawabata, T. Koshiba, G. Gao, Y. Nakamura, K. Koshimizu, and H. Ohigashi Nitric Oxide Synthase Is Induced in Tumor Promoter-sensitive, but not Tumor Promoter-resistant, JB6 Mouse Epidermal Cells Cocultured with Interferon- {{gamma}}-stimulated RAW 264.7 Cells: The Role of Tumor Necrosis Factor-{{alpha}} Cancer Res., November 1, 2000; 60(22): 6326 - 6331. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. K. Manna, A. Mukhopadhyay, and B. B. Aggarwal Resveratrol Suppresses TNF-Induced Activation of Nuclear Transcription Factors NF-{kappa}B, Activator Protein-1, and Apoptosis: Potential Role of Reactive Oxygen Intermediates and Lipid Peroxidation J. Immunol., June 15, 2000; 164(12): 6509 - 6519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-B. She, N. Chen, and Z. Dong ERKs and p38 Kinase Phosphorylate p53 Protein at Serine 15 in Response to UV Radiation J. Biol. Chem., June 30, 2000; 275(27): 20444 - 20449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nomura, A. Kaji, W.-Y. Ma, S. Zhong, G. Liu, G. T. Bowden, K.-i. Miyamoto, and Z. Dong Mitogen- and Stress-activated Protein Kinase 1 Mediates Activation of Akt by Ultraviolet B Irradiation J. Biol. Chem., June 29, 2001; 276(27): 25558 - 25567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. V. Kumar and L. R. Bernstein Ten ERK-related Proteins in Three Distinct Classes Associate with AP-1 Proteins and/or AP-1 DNA J. Biol. Chem., August 17, 2001; 276(34): 32362 - 32372. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
