| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 42, 29689-29693, October 15, 1999
From the Department of Psychiatry and Behavioral Neurobiology,
University of Alabama at Birmingham,
Birmingham, Alabama 35294-0017
RGS2, a member of the Regulators of
G-protein Signaling family, modulates the
activity of G-proteins coupled to the phosphoinositide signal
transduction system, but little is known about what regulates RGS2. In
human neuroblastoma SH-SY5Y cells stimulation of muscarinic receptors
by carbachol activates phosphoinositide signaling and also caused a
rapid, large, and long lasting increase in RGS2 mRNA levels. Direct
activation of protein kinase C also rapidly increased RGS2 mRNA
levels. Inhibition of protein kinase C with Ro31-8220, GF109203x, or
Go6976 or down-regulation of protein kinase C inhibited increases in
RGS2 mRNA levels induced by carbachol or by the activation of
protein kinase C. Blockade of calcium signaling did not alter
carbachol-induced increases in RGS2 mRNA levels. Neither activation
of epidermal growth factor receptors nor stimulation of cyclic AMP
production with forskolin increased RGS2 mRNA levels. Pretreatment
with actinomycin D blocked increases in RGS2 mRNA levels but caused
a surprisingly small, although statistically significant, partial
blockade of protein kinase C-mediated feedback inhibition of
carbachol-induced phosphoinositide hydrolysis. Thus, RGS2 mRNA
levels are increased by activation of muscarinic receptors coupled to
the phosphoinositide signal transduction system through a protein
kinase C-dependent mechanism. This action may contribute to
negative feedback control of this signaling cascade, but because the
small contribution to negative feedback contrasts with the large and
prolonged elevations in RGS2 mRNA levels, we speculate that its
primary role may be in modulating other signaling components.
This article has been cited by other articles:
|
|
 |
|
  Z. Xie, M. C. Gong, W. Su, J. Turk, and Z. Guo Group VIA Phospholipase A2 (iPLA2beta) Participates in Angiotensin II-induced Transcriptional Up-regulation of Regulator of G-protein Signaling-2 in Vascular Smooth Muscle Cells J. Biol. Chem., August 31, 2007; 282(35): 25278 - 25289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Romero, M. W. Plonczynski, E. P. Gomez-Sanchez, L. L. Yanes, and C. E. Gomez-Sanchez RGS2 Is Regulated by Angiotensin II and Functions as a Negative Feedback of Aldosterone Production in H295R Human Adrenocortical Cells Endocrinology, August 1, 2006; 147(8): 3889 - 3897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Watcharasit, G. N. Bijur, L. Song, J. Zhu, X. Chen, and R. S. Jope Glycogen Synthase Kinase-3{beta} (GSK3{beta}) Binds to and Promotes the Actions of p53 J. Biol. Chem., December 5, 2003; 278(49): 48872 - 48879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hollinger and J. R. Hepler Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling Pharmacol. Rev., September 1, 2002; 54(3): 527 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Benzing, M. B. Yaffe, T. Arnould, L. Sellin, B. Schermer, B. Schilling, R. Schreiber, K. Kunzelmann, G. G. Leparc, E. Kim, et al. 14-3-3 Interacts with Regulator of G Protein Signaling Proteins and Modulates Their Activity J. Biol. Chem., September 1, 2000; 275(36): 28167 - 28172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Park, C. O. Echetebu, S. Soloff, and M. S. Soloff Oxytocin stimulation of RGS2 mRNA expression in cultured human myometrial cells Am J Physiol Endocrinol Metab, March 1, 2002; 282(3): E580 - E584. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
