JBC Transcription and Nuclear Factor Monoclonals

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Uddin, S.
Right arrow Articles by Platanias, L. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Uddin, S.
Right arrow Articles by Platanias, L. C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

J Biol Chem, Vol. 274, Issue 42, 30127-30131, October 15, 1999

Activation of the p38 Mitogen-activated Protein Kinase by Type I Interferons

Shahab UddinDagger , Beata Majchrzak§, Joanna WoodsonDagger , Pony ArunkumarDagger , Yazan AlsayedDagger , Richard Pine, Peter R. Youngparallel , Eleanor N. Fish§, and Leonidas C. PlataniasDagger

From the Dagger  Section of Hematology-Oncology, The University of Illinois at Chicago and West Side Veterans Affairs Hospital, Chicago, Illinois 60607, the § Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 3E2, Canada, the  Public Health Research Institute, New York, New York 10016, and the parallel  Department of Molecular Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406

The p38 mitogen-activated protein (Map) kinase plays a critical role in the generation of signals in response to stress stimuli, but its role in interferon (IFN) signaling and its potential regulatory role in the activation of Jak-signal transducer and activator of transcription (Stat) pathway are not known. In the present study, we provide evidence that the p38 Map kinase is rapidly phosphorylated and activated during treatment of cells with Type I interferons (IFNalpha and IFNbeta ). Furthermore, the Type I IFN-dependent activation of p38 regulates induction of the catalytic domains of MapKap kinase-2 and MapKap kinase-3, strongly suggesting the existence of an IFNalpha signaling cascade activated downstream of the p38 kinase. The engagement of this pathway in interferon signaling plays a critical role in interferon-dependent transcriptional regulation, as evidenced by the fact that inhibition of p38 activation results in abrogation of interferon-dependent gene transcription via interferon-stimulated response elements. Interestingly, inhibition of the kinase activity of the p38 blocks IFNalpha -induced gene transcription without inhibiting DNA binding or tyrosine phosphorylation of Stat proteins, suggesting that the p38 pathway acts in cooperation with the Stat pathway. Thus, the p38 kinase signaling cascade is activated by the Type I interferon receptor and plays a critical role in interferon signaling and interferon-dependent transcriptional regulation.

Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
E. Katsoulidis, A. Sassano, B. Majchrzak-Kita, N. Carayol, P. Yoon, A. Jordan, B. J. Druker, E. N. Fish, and L. C. Platanias
Suppression of Interferon (IFN)-inducible Genes and IFN-mediated Functional Responses in BCR-ABL-expressing Cells
J. Biol. Chem., April 18, 2008; 283(16): 10793 - 10803.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Kaur, A. Sassano, B. Dolniak, S. Joshi, B. Majchrzak-Kita, D. P. Baker, N. Hay, E. N. Fish, and L. C. Platanias
Role of the Akt pathway in mRNA translation of interferon-stimulated genes
PNAS, March 25, 2008; 105(12): 4808 - 4813.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. K. Altman, P. Yoon, E. Katsoulidis, B. Kroczynska, A. Sassano, A. J. Redig, H. Glaser, A. Jordan, M. S. Tallman, N. Hay, et al.
Regulatory Effects of Mammalian Target of Rapamycin-mediated Signals in the Generation of Arsenic Trioxide Responses
J. Biol. Chem., January 25, 2008; 283(4): 1992 - 2001.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
Z. Zhou, O. J. Hamming, N. Ank, S. R. Paludan, A. L. Nielsen, and R. Hartmann
Type III Interferon (IFN) Induces a Type I IFN-Like Response in a Restricted Subset of Cells through Signaling Pathways Involving both the Jak-STAT Pathway and the Mitogen-Activated Protein Kinases
J. Virol., July 15, 2007; 81(14): 7749 - 7758.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Kaur, L. Lal, A. Sassano, B. Majchrzak-Kita, M. Srikanth, D. P. Baker, E. Petroulakis, N. Hay, N. Sonenberg, E. N. Fish, et al.
Regulatory Effects of Mammalian Target of Rapamycin-activated Pathways in Type I and II Interferon Signaling
J. Biol. Chem., January 19, 2007; 282(3): 1757 - 1768.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. A. Navas, M. Mohindru, M. Estes, J. Y. Ma, L. Sokol, P. Pahanish, S. Parmar, E. Haghnazari, L. Zhou, R. Collins, et al.
Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors
Blood, December 15, 2006; 108(13): 4170 - 4177.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
P. Yoon, N. Giafis, J. Smith, H. Mears, E. Katsoulidis, A. Sassano, J. Altman, A. J. Redig, M. S. Tallman, and L. C. Platanias
Activation of mammalian target of rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL-expressing cells.
Mol. Cancer Ther., November 1, 2006; 5(11): 2815 - 2823.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Kannan-Thulasiraman, E. Katsoulidis, M. S. Tallman, J. S. C. Arthur, and L. C. Platanias
Activation of the Mitogen- and Stress-activated Kinase 1 by Arsenic Trioxide
J. Biol. Chem., August 11, 2006; 281(32): 22446 - 22452.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Giafis, E. Katsoulidis, A. Sassano, M. S. Tallman, L. S. Higgins, A. R. Nebreda, R. J. Davis, and L. C. Platanias
Role of the p38 Mitogen-Activated Protein Kinase Pathway in the Generation of Arsenic Trioxide-Dependent Cellular Responses.
Cancer Res., July 1, 2006; 66(13): 6763 - 6771.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-W. Zhao, D. Li, Q. Zhao, Y. Huang, R. H. Silverman, P. J. Sims, and G.-Q. Chen
Interferon-{alpha}-induced Expression of Phospholipid Scramblase 1 through STAT1 Requires the Sequential Activation of Protein Kinase C{delta} and JNK
J. Biol. Chem., December 30, 2005; 280(52): 42707 - 42714.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. Katsoulidis, Y. Li, P. Yoon, A. Sassano, J. Altman, P. Kannan-Thulasiraman, L. Balasubramanian, S. Parmar, J. Varga, M. S. Tallman, et al.
Role of the p38 Mitogen-Activated Protein Kinase Pathway in Cytokine-Mediated Hematopoietic Suppression in Myelodysplastic Syndromes
Cancer Res., October 1, 2005; 65(19): 9029 - 9037.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Parmar, J. Smith, A. Sassano, S. Uddin, E. Katsoulidis, B. Majchrzak, S. Kambhampati, E. A. Eklund, M. S. Tallman, E. N. Fish, et al.
Differential regulation of the p70 S6 kinase pathway by interferon {alpha} (IFN{alpha}) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells
Blood, October 1, 2005; 106(7): 2436 - 2443.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Z. Du, Y. Shen, W. Yang, I. Mecklenbrauker, B. G. Neel, and L. B. Ivashkiv
Inhibition of IFN-{alpha} signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway
PNAS, July 19, 2005; 102(29): 10267 - 10272.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. Wessely
Interference by interferons: Janus faces in vascular proliferative diseases
Cardiovasc Res, June 1, 2005; 66(3): 433 - 443.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. M. Brierley and E. N. Fish
Functional Relevance of the Conserved DNA-binding Domain of STAT2
J. Biol. Chem., April 1, 2005; 280(13): 13029 - 13036.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Li, S. Batra, A. Sassano, B. Majchrzak, D. E. Levy, M. Gaestel, E. N. Fish, R. J. Davis, and L. C. Platanias
Activation of Mitogen-activated Protein Kinase Kinase (MKK) 3 and MKK6 by Type I Interferons
J. Biol. Chem., March 18, 2005; 280(11): 10001 - 10010.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
K. D. Ryman, K. C. Meier, E. M. Nangle, S. L. Ragsdale, N. L. Korneeva, R. E. Rhoads, M. R. MacDonald, and W. B. Klimstra
Sindbis Virus Translation Is Inhibited by a PKR/RNase L-Independent Effector Induced by Alpha/Beta Interferon Priming of Dendritic Cells
J. Virol., February 1, 2005; 79(3): 1487 - 1499.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S.-Z. Wang and R. M. Roberts
Interaction of Stress-Activated Protein Kinase-Interacting Protein-1 with the Interferon Receptor Subunit IFNAR2 in Uterine Endometrium
Endocrinology, December 1, 2004; 145(12): 5820 - 5831.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. G. Munshi, Y. I. Wu, S. Mukhopadhyay, A. J. Ottaviano, A. Sassano, J. E. Koblinski, L. C. Platanias, and M. S. Stack
Differential Regulation of Membrane Type 1-Matrix Metalloproteinase Activity by ERK 1/2- and p38 MAPK-modulated Tissue Inhibitor of Metalloproteinases 2 Expression Controls Transforming Growth Factor-{beta}1-induced Pericellular Collagenolysis
J. Biol. Chem., September 10, 2004; 279(37): 39042 - 39050.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Mukhopadhyay, H. G. Munshi, S. Kambhampati, A. Sassano, L. C. Platanias, and M. S. Stack
Calcium-induced Matrix Metalloproteinase 9 Gene Expression Is Differentially Regulated by ERK1/2 and p38 MAPK in Oral Keratinocytes and Oral Squamous Cell Carcinoma
J. Biol. Chem., August 6, 2004; 279(32): 33139 - 33146.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. K. Srivastava, S. Batra, A. Sassano, Y. Li, B. Majchrzak, H. Kiyokawa, A. Altman, E. N. Fish, and L. C. Platanias
Engagement of Protein Kinase C-{theta} in Interferon Signaling in T-cells
J. Biol. Chem., July 16, 2004; 279(29): 29911 - 29920.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Parmar, E. Katsoulidis, A. Verma, Y. Li, A. Sassano, L. Lal, B. Majchrzak, F. Ravandi, M. S. Tallman, E. N. Fish, et al.
Role of the p38 Mitogen-activated Protein Kinase Pathway in the Generation of the Effects of Imatinib Mesylate (STI571) in BCR-ABL-expressing Cells
J. Biol. Chem., June 11, 2004; 279(24): 25345 - 25352.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. A. Gold, Y. Hoshino, S. Hoshino, M. B. Jones, A. Nolan, and M. D. Weiden
Exogenous Gamma and Alpha/Beta Interferon Rescues Human Macrophages from Cell Death Induced by Bacillus anthracis
Infect. Immun., March 1, 2004; 72(3): 1291 - 1297.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Li, A. Sassano, B. Majchrzak, D. K. Deb, D. E. Levy, M. Gaestel, A. R. Nebreda, E. N. Fish, and L. C. Platanias
Role of p38{alpha} Map Kinase in Type I Interferon Signaling
J. Biol. Chem., January 9, 2004; 279(2): 970 - 979.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Uddin, J. Ah-Kang, J. Ulaszek, D. Mahmud, and A. Wickrema
Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells
PNAS, January 6, 2004; 101(1): 147 - 152.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. M. U. Hilkens, J. F. Schlaak, and I. M. Kerr
Differential Responses to IFN-{alpha} Subtypes in Human T Cells and Dendritic Cells
J. Immunol., November 15, 2003; 171(10): 5255 - 5263.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Kambhampati, Y. Li, A. Verma, A. Sassano, B. Majchrzak, D. K. Deb, S. Parmar, N. Giafis, D. V. Kalvakolanu, A. Rahman, et al.
Activation of Protein Kinase C{delta} by All-trans-retinoic Acid
J. Biol. Chem., August 29, 2003; 278(35): 32544 - 32551.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Lekmine, S. Uddin, A. Sassano, S. Parmar, S. M. Brachmann, B. Majchrzak, N. Sonenberg, N. Hay, E. N. Fish, and L. C. Platanias
Activation of the p70 S6 Kinase and Phosphorylation of the 4E-BP1 Repressor of mRNA Translation by Type I Interferons
J. Biol. Chem., July 18, 2003; 278(30): 27772 - 27780.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. K. Deb, A. Sassano, F. Lekmine, B. Majchrzak, A. Verma, S. Kambhampati, S. Uddin, A. Rahman, E. N. Fish, and L. C. Platanias
Activation of Protein Kinase C{delta} by IFN-{gamma}
J. Immunol., July 1, 2003; 171(1): 267 - 273.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. C. Platanias
Map kinase signaling pathways and hematologic malignancies
Blood, June 15, 2003; 101(12): 4667 - 4679.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. Xu, A. Bhattacharjee, B. Roy, H.-M. Xu, D. Anthony, D. A. Frank, G. M. Feldman, and M. K. Cathcart
Interleukin-13 Induction of 15-Lipoxygenase Gene Expression Requires p38 Mitogen-Activated Protein Kinase-Mediated Serine 727 Phosphorylation of Stat1 and Stat3
Mol. Cell. Biol., June 1, 2003; 23(11): 3918 - 3928.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Gomez and N. C. Reich
Stimulation of Primary Human Endothelial Cell Proliferation by IFN
J. Immunol., June 1, 2003; 170(11): 5373 - 5381.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. C. Malcolm and G. S. Worthen
Lipopolysaccharide Stimulates p38-dependent Induction of Antiviral Genes in Neutrophils Independently of Paracrine Factors
J. Biol. Chem., April 25, 2003; 278(18): 15693 - 15701.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
V. S. Cull, P. A. Tilbrook, E. J. Bartlett, N. L. Brekalo, and C. M. James
Type I interferon differential therapy for erythroleukemia: specificity of STAT activation
Blood, April 1, 2003; 101(7): 2727 - 2735.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Ravandi, M. Talpaz, and Z. Estrov
Modulation of Cellular Signaling Pathways: Prospects for Targeted Therapy in Hematological Malignancies
Clin. Cancer Res., February 1, 2003; 9(2): 535 - 550.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. F. Schlaak, C. M. U. Hilkens, A. P. Costa-Pereira, B. Strobl, F. Aberger, A.-M. Frischauf, and I. M. Kerr
Cell-type and Donor-specific Transcriptional Responses to Interferon-alpha . USE OF CUSTOMIZED GENE ARRAYS
J. Biol. Chem., December 13, 2002; 277(51): 49428 - 49437.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Wang, R. D. Schreiber, and I. L. Campbell
STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the central nervous system
PNAS, December 10, 2002; 99(25): 16209 - 16214.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Verma, M. Mohindru, D. K. Deb, A. Sassano, S. Kambhampati, F. Ravandi, S. Minucci, D. V. Kalvakolanu, and L. C. Platanias
Activation of Rac1 and the p38 Mitogen-activated Protein Kinase Pathway in Response to Arsenic Trioxide
J. Biol. Chem., November 15, 2002; 277(47): 44988 - 44995.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Pesu, S. Aittomaki, K. Takaluoma, A. Lagerstedt, and O. Silvennoinen
p38 Mitogen-activated Protein Kinase Regulates Interleukin-4-induced Gene Expression by Stimulating STAT6-mediated Transcription
J. Biol. Chem., October 4, 2002; 277(41): 38254 - 38261.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. R. S. Rani, L. Hibbert, N. Sizemore, G. R. Stark, and R. M. Ransohoff
Requirement of Phosphoinositide 3-Kinase and Akt for Interferon-beta -mediated Induction of the beta -R1 (SCYB11) Gene
J. Biol. Chem., October 4, 2002; 277(41): 38456 - 38461.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Verma, D. K. Deb, A. Sassano, S. Kambhampati, A. Wickrema, S. Uddin, M. Mohindru, K. Van Besien, and L. C. Platanias
Cutting Edge: Activation of the p38 Mitogen-Activated Protein Kinase Signaling Pathway Mediates Cytokine-Induced Hemopoietic Suppression in Aplastic Anemia
J. Immunol., June 15, 2002; 168(12): 5984 - 5988.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. K. Roy, J. Hu, Q. Meng, Y. Xia, P. S. Shapiro, S. P. M. Reddy, L. C. Platanias, D. J. Lindner, P. F. Johnson, C. Pritchard, et al.
MEKK1 plays a critical role in activating the transcription factor C/EBP-beta -dependent gene expression in response to IFN-gamma
PNAS, June 11, 2002; 99(12): 7945 - 7950.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Haq, A. Halupa, B. K. Beattie, J. M. Mason, B. W. Zanke, and D. L. Barber
Regulation of Erythropoietin-induced STAT Serine Phosphorylation by Distinct Mitogen-activated Protein Kinases
J. Biol. Chem., May 3, 2002; 277(19): 17359 - 17366.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Uddin, A. Sassano, D. K. Deb, A. Verma, B. Majchrzak, A. Rahman, A. B. Malik, E. N. Fish, and L. C. Platanias
Protein Kinase C-delta (PKC-delta ) Is Activated by Type I Interferons and Mediates Phosphorylation of Stat1 on Serine 727
J. Biol. Chem., April 19, 2002; 277(17): 14408 - 14416.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Verma, D. K. Deb, A. Sassano, S. Uddin, J. Varga, A. Wickrema, and L. C. Platanias
Activation of the p38 Mitogen-activated Protein Kinase Mediates the Suppressive Effects of Type I Interferons and Transforming Growth Factor-beta on Normal Hematopoiesis
J. Biol. Chem., March 1, 2002; 277(10): 7726 - 7735.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. T. Jacobs and L. J. Ignarro
Lipopolysaccharide-induced Expression of Interferon-beta Mediates the Timing of Inducible Nitric-oxide Synthase Induction in RAW 264.7 Macrophages
J. Biol. Chem., December 14, 2001; 276(51): 47950 - 47957.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F. Doualla-Bell and A. E. Koromilas
Induction of PG G/H Synthase-2 in Bovine Myometrial Cells by Interferon-{tau} Requires the Activation of the p38 MAPK Pathway
Endocrinology, December 1, 2001; 142(12): 5107 - 5115.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Rahman, K. N. Anwar, S. Uddin, N. Xu, R. D. Ye, L. C. Platanias, and A. B. Malik
Protein Kinase C-{delta} Regulates Thrombin-Induced ICAM-1 Gene Expression in Endothelial Cells via Activation of p38 Mitogen-Activated Protein Kinase
Mol. Cell. Biol., August 15, 2001; 21(16): 5554 - 5565.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Russell-Harde, T. C. Wagner, M. R. S. Rani, D. Vogel, O. Colamonici, R. M. Ransohoff, B. Majchrzak, E. Fish, H. D. Perez, and E. Croze
Role of the Intracellular Domain of the Human Type I Interferon Receptor 2 Chain (IFNAR2c) in Interferon Signaling. EXPRESSION OF IFNAR2c TRUNCATION MUTANTS IN U5A CELLS
J. Biol. Chem., July 28, 2000; 275(31): 23981 - 23985.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Uddin, F. Lekmine, N. Sharma, B. Majchrzak, I. Mayer, P. R. Young, G. M. Bokoch, E. N. Fish, and L. C. Platanias
The Rac1/p38 Mitogen-activated Protein Kinase Pathway Is Required for Interferon alpha -dependent Transcriptional Activation but Not Serine Phosphorylation of Stat Proteins
J. Biol. Chem., September 1, 2000; 275(36): 27634 - 27640.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Hu, S. K. Roy, P. S. Shapiro, S. R. Rodig, S. P. M. Reddy, L. C. Platanias, R. D. Schreiber, and D. V. Kalvakolanu
ERK1 and ERK2 Activate CCAAAT/Enhancer-binding Protein-beta -dependent Gene Transcription in Response to Interferon-gamma
J. Biol. Chem., January 5, 2001; 276(1): 287 - 297.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Alsayed, S. Uddin, N. Mahmud, F. Lekmine, D. V. Kalvakolanu, S. Minucci, G. Bokoch, and L. C. Platanias
Activation of Rac1 and the p38 Mitogen-activated Protein Kinase Pathway in Response to All-trans-retinoic Acid
J. Biol. Chem., February 2, 2001; 276(6): 4012 - 4019.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. M. Gamero and A. C. Larner
Vanadate Facilitates Interferon alpha -mediated Apoptosis That Is Dependent on the Jak/Stat Pathway
J. Biol. Chem., April 20, 2001; 276(17): 13547 - 13553.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Wong, S. Uddin, B. Majchrzak, T. Huynh, A. E. I. Proudfoot, L. C. Platanias, and E. N. Fish
RANTES Activates Jak2 and Jak3 to Regulate Engagement of Multiple Signaling Pathways in T Cells
J. Biol. Chem., March 30, 2001; 276(14): 11427 - 11431.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. A. Mayer, A. Verma, I. M. Grumbach, S. Uddin, F. Lekmine, F. Ravandi, B. Majchrzak, S. Fujita, E. N. Fish, and L. C. Platanias
The p38 MAPK Pathway Mediates the Growth Inhibitory Effects of Interferon-alpha in BCR-ABL-expressing Cells
J. Biol. Chem., July 20, 2001; 276(30): 28570 - 28577.
[Abstract]