| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 43, 30644-30650, October 22, 1999
From the Departments of Activation of Akt by multiple stimuli including B
cell antigen receptor (BCR) engagement requires phosphatidylinositol
3-kinase and regulates processes including cell survival,
proliferation, and metabolism. BCR cross-linking activates three
families of non-receptor protein tyrosine kinases (PTKs) and these are
transducers of signaling events including phospholipase C and
mitogen-activated protein kinase activation; however, the relative
roles of PTKs in BCR-mediated Akt activation are unknown. We examined
Akt activation in Lyn-, Syk- and Btk-deficient DT40 cells and B cells
from Lyn
Syk and Bruton's Tyrosine Kinase Are Required for B Cell Antigen
Receptor-mediated Activation of the Kinase Akt
,,
Microbiology and
Immunology, University of Washington, Seattle, Washington 98195 and the ¶ Department of Molecular Genetics, Institute for Liver
Research, Kansai Medical University, Moriguchi 570, Japan
/ mice. BCR-mediated Akt activation
required Syk and was partially dependent upon Btk. Increased
BCR-induced Akt phosphorylation was observed in Lyn-deficient DT40
cells and Lyn/ mice compared with wild-type cells
suggesting that Lyn may negatively regulate Akt function. BCR-induced
tyrosine phosphorylation of the phosphatidylinositol 3-kinase catalytic
subunit was abolished in Syk-deficient cells consistent with a
receptor-proximal role for Syk in BCR-mediated phosphatidylinositol
3-kinase activation; in contrast, it was maintained in Btk-deficient
cells, suggesting Btk functions downstream of phosphatidylinositol
3-kinase. Calcium depletion did not influence BCR-induced Akt
phosphorylation/activation, showing that neither Syk nor Btk mediates
its effects via changes in calcium levels. Thus, BCR-mediated Akt
stimulation is regulated by multiple non-receptor PTK families which
regulate Akt both proximal and distal to phosphatidylinositol 3-kinase activation.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Gururajan, T. Dasu, S. Shahidain, C. D. Jennings, D. A. Robertson, V. M. Rangnekar, and S. Bondada Spleen Tyrosine Kinase (Syk), a Novel Target of Curcumin, Is Required for B Lymphoma Growth J. Immunol., January 1, 2007; 178(1): 111 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Patke, I. Mecklenbrauker, H. Erdjument-Bromage, P. Tempst, and A. Tarakhovsky BAFF controls B cell metabolic fitness through a PKC{beta}- and Akt-dependent mechanism J. Exp. Med., October 30, 2006; 203(11): 2551 - 2562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Craxton, K. E. Draves, A. Gruppi, and E. A. Clark BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway J. Exp. Med., November 21, 2005; 202(10): 1363 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ruiz-Ballesteros, M. Mollejo, A. Rodriguez, F. I. Camacho, P. Algara, N. Martinez, M. Pollan, A. Sanchez-Aguilera, J. Menarguez, E. Campo, et al. Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis Blood, September 1, 2005; 106(5): 1831 - 1838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Mikhalap, L. M. Shlapatska, O. V. Yurchenko, M. Y. Yurchenko, G. G. Berdova, K. E. Nichols, E. A. Clark, and S. P. Sidorenko The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells Blood, December 15, 2004; 104(13): 4063 - 4070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Guo, G. Z. Ferl, R. Deora, M. Riedinger, S. Yin, J. L. Kerwin, J. A. Loo, and O. N. Witte A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-{gamma} activation PNAS, September 28, 2004; 101(39): 14180 - 14185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Allam, H. Niiro, E. A. Clark, and A. J. Marshall The Adaptor Protein Bam32 Regulates Rac1 Activation and Actin Remodeling through a Phosphorylation-dependent Mechanism J. Biol. Chem., September 17, 2004; 279(38): 39775 - 39782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Takada and B. B. Aggarwal TNF Activates Syk Protein Tyrosine Kinase Leading to TNF-Induced MAPK Activation, NF-{kappa}B Activation, and Apoptosis J. Immunol., July 15, 2004; 173(2): 1066 - 1077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Yang, J.-H. Yoon, and K. C. Chung Bruton's Tyrosine Kinase Phosphorylates cAMP-responsive Element-binding Protein at Serine 133 during Neuronal Differentiation in Immortalized Hippocampal Progenitor Cells J. Biol. Chem., January 16, 2004; 279(3): 1827 - 1837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Spaargaren, E. A. Beuling, M. L. Rurup, H. P. Meijer, M. D. Klok, S. Middendorp, R. W. Hendriks, and S. T. Pals The B Cell Antigen Receptor Controls Integrin Activity through Btk and PLC{gamma}2 J. Exp. Med., November 17, 2003; 198(10): 1539 - 1550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Whyburn, K. E. Halcomb, C. M. Contreras, C. A. Lowell, O. N. Witte, and A. B. Satterthwaite Reduced Dosage of Bruton's Tyrosine Kinase Uncouples B Cell Hyperresponsiveness from Autoimmunity in lyn-/- Mice J. Immunol., August 15, 2003; 171(4): 1850 - 1858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yokozeki, K. Adler, D. Lankar, and C. Bonnerot B Cell Receptor-Mediated Syk-Independent Activation of Phosphatidylinositol 3-Kinase, Ras, and Mitogen-Activated Protein Kinase Pathways J. Immunol., August 1, 2003; 171(3): 1328 - 1335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Craxton, D. Magaletti, E. J. Ryan, and E. A. Clark Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF Blood, June 1, 2003; 101(11): 4464 - 4471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Conus, K. M. Hannan, B. E. Cristiano, B. A. Hemmings, and R. B. Pearson Direct Identification of Tyrosine 474 as a Regulatory Phosphorylation Site for the Akt Protein Kinase J. Biol. Chem., October 4, 2002; 277(41): 38021 - 38028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Marshall, A. K. Krahn, K. Ma, V. Duronio, and S. Hou TAPP1 and TAPP2 Are Targets of Phosphatidylinositol 3-Kinase Signaling in B Cells: Sustained Plasma Membrane Recruitment Triggered by the B-Cell Antigen Receptor Mol. Cell. Biol., August 1, 2002; 22(15): 5479 - 5491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Christian, P. V. Sims, and M. R. Gold The B Cell Antigen Receptor Regulates the Transcriptional Activator {beta}-Catenin Via Protein Kinase C-Mediated Inhibition of Glycogen Synthase Kinase-3 J. Immunol., July 15, 2002; 169(2): 758 - 769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Jiang, B. Zhong, D. L. Gilvary, B. C. Corliss, E. Vivier, E. Hong-Geller, S. Wei, and J. Y. Djeu Syk Regulation of Phosphoinositide 3-Kinase-Dependent NK Cell Function J. Immunol., April 1, 2002; 168(7): 3155 - 3164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. Su and D. J. Rawlings Transitional B Lymphocyte Subsets Operate as Distinct Checkpoints in Murine Splenic B Cell Development J. Immunol., March 1, 2002; 168(5): 2101 - 2110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Niiro, A. Maeda, T. Kurosaki, and E. A. Clark The B Lymphocyte Adaptor Molecule of 32 kD (Bam32) Regulates B Cell Antigen Receptor Signaling and Cell Survival J. Exp. Med., January 7, 2002; 195(1): 143 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Gary-Gouy, J. Harriague, A. Dalloul, E. Donnadieu, and G. Bismuth CD5-Negative Regulation of B Cell Receptor Signaling Pathways Originates from Tyrosine Residue Y429 Outside an Immunoreceptor Tyrosine-Based Inhibitory Motif J. Immunol., January 1, 2002; 168(1): 232 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Stephens, K. E. Anderson, and P. T. Hawkins Src Family Kinases Mediate Receptor-stimulated, Phosphoinositide 3-Kinase-dependent, Tyrosine Phosphorylation of Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides-1 in Endothelial and B Cell Lines J. Biol. Chem., November 9, 2001; 276(46): 42767 - 42773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. Hsu, A. C. Lochan, and D. S. Cowen Activation of Akt1 by Human 5-Hydroxytryptamine (Serotonin)1B Receptors Is Sensitive to Inhibitors of MEK J. Pharmacol. Exp. Ther., August 1, 2001; 298(2): 825 - 832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Bates, N. S. Edwards, G. F. Burns, and D. E. Fisher A CD44 Survival Pathway Triggers Chemoresistance via Lyn Kinase and Phosphoinositide 3-Kinase/Akt in Colon Carcinoma Cells Cancer Res., July 1, 2001; 61(13): 5275 - 5283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jiang and E. A. Clark Involvement of Bik, a Proapoptotic Member of the Bcl-2 Family, in Surface IgM-Mediated B Cell Apoptosis J. Immunol., May 15, 2001; 166(10): 6025 - 6033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Lang, L. Shen, H. Gao, W. F. Cusack, G. A. Lang, and W. F. Wade Fc{{alpha}} Receptor Cross-Linking Causes Translocation of Phosphatidylinositol-Dependent Protein Kinase 1 and Protein Kinase B{{alpha}} to MHC Class II Peptide-Loading-Like Compartments J. Immunol., May 1, 2001; 166(9): 5585 - 5593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Swart, I. K. Ruf, J. Sample, and R. Longnecker Latent Membrane Protein 2A-Mediated Effects on the Phosphatidylinositol 3-Kinase/Akt Pathway J. Virol., November 15, 2000; 74(22): 10838 - 10845. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Epler, R. Liu, H. Chung, N. C. Ottoson, and Y. Shimizu Regulation of {beta}1 Integrin-Mediated Adhesion by T Cell Receptor Signaling Involves ZAP-70 but Differs from Signaling Events That Regulate Transcriptional Activity J. Immunol., November 1, 2000; 165(9): 4941 - 4949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Merchant, R. G. Caldwell, and R. Longnecker The LMP2A ITAM Is Essential for Providing B Cells with Development and Survival Signals In Vivo J. Virol., October 1, 2000; 74(19): 9115 - 9124. [Abstract] [Full Text]
|
|
|
|
|
|
J. Kitaura, K. Asai, M. Maeda-Yamamoto, Y. Kawakami, U. Kikkawa, and T. Kawakami Akt-dependent Cytokine Production in Mast Cells J. Exp. Med., September 5, 2000; 192(5): 729 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Carver, M. J. Aman, and K. S. Ravichandran SHIP inhibits Akt activation in B cells through regulation of Akt membrane localization Blood, August 15, 2000; 96(4): 1449 - 1456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Pogue, T. Kurosaki, J. Bolen, and R. Herbst B Cell Antigen Receptor-Induced Activation of Akt Promotes B Cell Survival and Is Dependent on Syk Kinase J. Immunol., August 1, 2000; 165(3): 1300 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Petro, S.M. J. Rahman, D. W. Ballard, and W. N. Khan Bruton's Tyrosine Kinase Is Required for Activation of I{kappa}B Kinase and Nuclear Factor {kappa}B in Response to B Cell Receptor Engagement J. Exp. Med., May 15, 2000; 191(10): 1745 - 1754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Marshall, H. Niiro, C. G. Lerner, T. J. Yun, S. Thomas, C. M. Disteche, and E. A. Clark A Novel B Lymphocyte-associated Adaptor Protein, Bam32, Regulates Antigen Receptor Signaling Downstream of Phosphatidylinositol 3-Kinase J. Exp. Med., April 18, 2000; 191(8): 1319 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Chen, O. Kim, J. Yang, K. Sato, K. M. Eisenmann, J. McCarthy, H. Chen, and Y. Qiu Regulation of Akt/PKB Activation by Tyrosine Phosphorylation J. Biol. Chem., August 17, 2001; 276(34): 31858 - 31862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fujimoto, J. C. Poe, M. Hasegawa, and T. F. Tedder CD19 Amplification of B Lymphocyte Ca2+ Responses. A ROLE FOR Lyn SEQUESTRATION IN EXTINGUISHING NEGATIVE REGULATION J. Biol. Chem., November 21, 2001; 276(48): 44820 - 44827. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
