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J Biol Chem, Vol. 274, Issue 43, 30764-30769, October 22, 1999
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From the Presenilin proteins are involved in familial
Alzheimer's disease, a neurodegenerative disorder characterized by
massive death of neurons. We describe a direct interaction between
presenilin 1 (PS1) and Bcl-2, a key factor in the regulation of
apoptosis, by yeast two-hybrid interaction system, by
co-immunoprecipitation, and by cross-linking experiments. Our data show
that PS1 and Bcl-2 assemble into a macromolecular complex, and that
they are released from this complex in response to an apoptotic
stimulus induced by staurosporine. The results support the idea of
cross-talk between these two proteins during apoptosis.
Istituto di Ricovero e Cura a Carattere
Scientifico (IRCCS) Centro S. Giovanni di Dio, Neurobiology Laboratory,
Alzheimer's Disease Unit, Via Pilastroni 4, 25123 Brescia, Italy, the
¶ Institute of Chemistry, Medical School, University of Brescia,
25124 Brescia, Italy, the Department of Experimental Medicine
and Biochemical Sciences, University of Rome Tor Vergata, 00154 Rome,
Italy, the Department of Psychiatry
Research, University of Zurich, CH-8091 Zurich, Switzerland, and
the ** Department of Neurology, Harvard Medical School, Boston,
Massachusetts 02114-3139
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