Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yamada, K.
Right arrow Articles by Okazaki, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamada, K.
Right arrow Articles by Okazaki, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

J Biol Chem, Vol. 274, Issue 45, 32279-32286, November 5, 1999

A GCM Motif Protein Is Involved in Placenta-specific Expression of Human Aromatase Gene

Kazuyo YamadaDagger §, Hisamitsu Ogawaparallel , Shin-ichiro Honda**, Nobuhiro Harada**, and Tsuneko OkazakiDagger §

From the Dagger  Institute for Comprehensive Medical Science, § CREST, Japan Science and Technology Corporation, parallel  Department of Biology, and ** Department of Biochemistry, Fujita Health University, School of Medicine, Toyoake, Aichi 470-1192, Japan

A new cis-element, trophoblast-specific element 2 (TSE2) is located in the placenta-specific enhancer of the human aromatase gene that dictates its tissue-specific expression. In the minimum enhancer region, an element similar to the trophoblast-specific element (TSE), originally described for the human chorionic gonadotropin alpha -subunit gene, also exists (Yamada, K., Harada, N., Honda, S., and Takagi, Y. (1995) J. Biol. Chem. 270, 25064-25069). The co-presence of TSE and TSE2 is required to direct trophoblast-specific expression driven by a heterologous thymidine kinase promoter. A 2562-base pair cDNA clone encoding a 436-amino acid protein that binds to TSE2 was isolated from a human placental cDNA library using a yeast one-hybrid system with the TSE2 as a reporter sequence. The protein was revealed to be identical to hGCMa, a mammalian homologue of the Drosophila GCM (glia cells missing) protein. Expression of hGCMa is restricted to the placenta. The protein also binds to PLE1 in the leptin promoter among other cis-elements reported to confer placenta-specific expression, suggesting that hGCMa is a placenta-specific transcription regulator, possibly involved in the expression of multiple placenta-specific genes.

Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
M.-H. Chiang, F.-Y. Liang, C.-P. Chen, C.-W. Chang, M.-L. Cheong, L.-J. Wang, C.-Y. Liang, F.-Y. Lin, C.-C. Chou, and H. Chen
Mechanism of Hypoxia-induced GCM1 Degradation: IMPLICATIONS FOR THE PATHOGENESIS OF PREECLAMPSIA
J. Biol. Chem., June 26, 2009; 284(26): 17411 - 17419.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. M. de Mestre, D. Miller, M. S. Roberson, J. Liford, L. C. Chizmar, K. E. McLaughlin, and D. F. Antczak
Glial Cells Missing Homologue 1 Is Induced in Differentiating Equine Chorionic Girdle Trophoblast Cells
Biol Reprod, February 1, 2009; 80(2): 227 - 234.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Chang, D. Mukherjea, R. M. Gobble, K. A. Groesch, R. J. Torry, and D. S. Torry
Glial Cell Missing 1 Regulates Placental Growth Factor (PGF) Gene Transcription in Human Trophoblast
Biol Reprod, May 1, 2008; 78(5): 841 - 851.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. W. Schubert, N. Lamoureux, K. Kilian, L. Klein-Hitpass, and S. Hashemolhosseini
Identification of Integrin-{alpha}4, Rb1, and Syncytin A as Murine Placental Target Genes of the Transcription Factor GCMa/Gcm1
J. Biol. Chem., February 29, 2008; 283(9): 5460 - 5465.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
J. Cai, J. Chen, Y. Liu, T. Miura, Y. Luo, J. F. Loring, W. J. Freed, M. S. Rao, and X. Zeng
Assessing Self-Renewal and Differentiation in Human Embryonic Stem Cell Lines
Stem Cells, March 1, 2006; 24(3): 516 - 530.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
Y.-H. Cheng and S. Handwerger
A Placenta-Specific Enhancer of the Human Syncytin Gene
Biol Reprod, September 1, 2005; 73(3): 500 - 509.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Kamat, M. E. Smith, J. M. Shelton, J. A. Richardson, and C. R. Mendelson
Genomic Regions that Mediate Placental Cell-Specific and Developmental Regulation of Human Cyp19 (Aromatase) Gene Expression in Transgenic Mice
Endocrinology, May 1, 2005; 146(5): 2481 - 2488.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C.-S. Yang, C. Yu, H.-C. Chuang, C.-W. Chang, G.-D. Chang, T.-P. Yao, and H. Chen
FBW2 Targets GCMa to the Ubiquitin-Proteasome Degradation System
J. Biol. Chem., March 18, 2005; 280(11): 10083 - 10090.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. H. Payne and D. B. Hales
Overview of Steroidogenic Enzymes in the Pathway from Cholesterol to Active Steroid Hormones
Endocr. Rev., December 1, 2004; 25(6): 947 - 970.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. W. Schubert, E. Kardash, M. A. Khan, T. Cheusova, K. Kilian, M. Wegner, and S. Hashemolhosseini
Interaction, Cooperative Promoter Modulation, and Renal Colocalization of GCMa and Pitx2
J. Biol. Chem., November 26, 2004; 279(48): 50358 - 50365.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Prudhomme, G. Oriol, and F. Mallet
A Retroviral Promoter and a Cellular Enhancer Define a Bipartite Element Which Controls env ERVWE1 Placental Expression
J. Virol., November 15, 2004; 78(22): 12157 - 12168.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S. Hashemolhosseini and M. Wegner
Impacts of a new transcription factor family: mammalian GCM proteins in health and disease
J. Cell Biol., September 13, 2004; 166(6): 765 - 768.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Iwasaki, T. Hosoya, H. Takebayashi, Y. Ogawa, Y. Hotta, and K. Ikenaka
The potential to induce glial differentiation is conserved between Drosophila and mammalian glial cells missing genes
Development, December 15, 2003; 130(24): 6027 - 6035.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
Y. Ikoma, S. Nomura, T. Ito, Y. Katsumata, M. Nakata, K. Iwanaga, M. Okada, F. Kikkawa, K. Tamakoshi, T. Nagasaka, et al.
Interleukin-1{beta} stimulates placental leucine aminopeptidase/oxytocinase expression in BeWo choriocarcinoma cells
Mol. Hum. Reprod., February 1, 2003; 9(2): 103 - 110.
[Abstract] [Full Text] [PDF]

Home page
 Recent Prog Horm ResHome page
J. C. Cross, L. Anson-Cartwright, and I. C. Scott
Transcription Factors Underlying the Development and Endocrine Functions of the Placenta
Recent Prog. Horm. Res., January 1, 2002; 57(1): 221 - 234.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
B. Nait–Oumesmar, A. B. Copperman, and R. A. Lazzarini
Placental Expression and Chromosomal Localization of the Human Gcm 1 Gene
J. Histochem. Cytochem., July 1, 2000; 48(7): 915 - 922.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 1999 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement