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J Biol Chem, Vol. 274, Issue 47, 33198-33201, November 19, 1999

COMMUNICATION
A Feedback Loop Coupling 5 S rRNA Synthesis to Accumulation of a Ribosomal Protein

Robin H. Pittman, Matthew T. Andrews^¶, and David R. Setzer

From the  Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 and the ^¶ Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695

We have shown that elevated expression of ribosomal protein L5 in Xenopus embryos results in the ectopic activation of 5 S rRNA genes that are normally inactive. This transcriptional stimulation mimics the effect of overexpressing transcription factor IIIA (TFIIIA), the 5 S rRNA gene-specific transcription factor. The results support a model in which a network of nucleic acid-protein interactions involving 5 S rRNA, the 5 S rRNA gene, TFIIIA, and L5 mediates both feedback inhibition of 5 S rRNA synthesis and coupling of 5 S rRNA synthesis to accumulation of a ribosomal protein, L5. We propose that these mechanisms contribute to the homeostatic control of ribosome assembly.

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Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.

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