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J Biol Chem, Vol. 274, Issue 47, 33206-33208, November 19, 1999

COMMUNICATION
Increased Proliferation Rate of Lymphoid Cells Transfected with the P2X7 ATP Receptor

O. Roberto BaricordiDagger §, Loredana MelchiorriDagger , Elena AdinolfiDagger , Simonetta Falzoni, Paola Chiozzi, Gary Buellparallel , and Francesco Di Virgilio§

From the Sections of Dagger  Medical Genetics and  General Pathology, Department of Experimental and Diagnostic Medicine and the § Biotechnology Center, University of Ferrara, I-44100 Ferrara, Italy and parallel  Ares-Serono, 1228 Geneva, Switzerland

Human leukocytes can express the P2X7 purinergic receptor, an ionic channel gated by extracellular ATP, for which the physiological role is only partially understood. Transfection of P2X7 cDNA into lymphoid cells that lack this receptor sustains their proliferation in serum-free medium. Increased proliferation of serum-starved P2X7 transfectants is abolished by the P2X7 receptor blocker oxidized ATP or by the ATP hydrolase apyrase. Both wild type and P2X7-transfected lymphoid cells release large amounts of ATP into the culture medium. These data suggest the operation of an ATP-based autocrine/paracrine loop that supports lymphoid cell growth in the absence of serum-derived growth factors.

Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.


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