| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 47, 33398-33402, November 19, 1999
,,
,
From the The clearance of free cholesterol from plasma
lipoproteins by tissues is of major quantitative importance, but it is
not known whether this is passive or receptor-mediated. Based on our
finding that scavenger receptor BI (SR-BI) promotes free cholesterol
(FC) exchange between high density lipoprotein (HDL) and cells, we tested whether SR-BI would effect FC movement in vivo using
[14C]FC- and [3H]cholesteryl ester
(CE)-labeled HDL in mice with increased (SR-BI transgenic (Tg)) or
decreased (SR-BI attenuated (att)) hepatic SR-BI expression. The
initial clearance of HDL FC was increased in SR-BI Tg mice by 72% and
decreased in SR-BI att mice by 53%, but was unchanged in apoA-I
knockout mice compared with wild-type mice. Transfer of FC to non-HDL
and esterification of FC were minor and could not explain differences.
The hepatic uptake of FC was increased in SR-BI Tg mice by 34% and
decreased in SR-BI att mice by 22%. CE clearance and uptake gave
similar results, but with much slower rates. The uptake of HDL FC and
CE by SR-BI Tg primary hepatocytes was increased by 2.2- and 2.6-fold
(1-h incubation), respectively, compared with control hepatocytes. In
SR-BI Tg mice, the initial biliary secretion of [14C]FC
was markedly increased, whereas increased [3H]FC appeared
after a slight delay. Thus, in the mouse, a major portion of the
clearance of HDL FC from plasma is mediated by SR-BI.
Division of Molecular Medicine, Millennium Pharmaceuticals, Inc.,
Cambridge, Massachusetts 02139
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
This article has been cited by other articles:
|
|
 |
|
  U. J. F. Tietge, N. Nijstad, R. Havinga, J. F. W. Baller, F. H. van der Sluijs, V. W. Bloks, T. Gautier, and F. Kuipers Secretory phospholipase A2 increases SR-BI-mediated selective uptake from HDL but not biliary cholesterol secretion J. Lipid Res., March 1, 2008; 49(3): 563 - 571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-D. Wang, V. Franklin, and Y. L. Marcel In Vivo Reverse Cholesterol Transport From Macrophages Lacking ABCA1 Expression Is Impaired Arterioscler. Thromb. Vasc. Biol., August 1, 2007; 27(8): 1837 - 1842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Wang, Y. Jiao, and C. Montell Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction J. Cell Biol., April 23, 2007; 177(2): 305 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tanaka, J. Delgado-Lista, J. Lopez-Miranda, F. Perez-Jimenez, C. Marin, P. Perez-Martinez, P. Gomez, and J. M. Ordovas Scavenger Receptor Class B Type I (SCARB1) c.1119C>T Polymorphism Affects Postprandial Triglyceride Metabolism in Men J. Nutr., March 1, 2007; 137(3): 578 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Yesilaltay, O. Kocher, R. Pal, A. Leiva, V. Quinones, A. Rigotti, and M. Krieger PDZK1 Is Required for Maintaining Hepatic Scavenger Receptor, Class B, Type I (SR-BI) Steady State Levels but Not Its Surface Localization or Function J. Biol. Chem., September 29, 2006; 281(39): 28975 - 28980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Singaraja, B. Stahmer, M. Brundert, M. Merkel, J. Heeren, N. Bissada, M. Kang, J. M. Timmins, R. Ramakrishnan, J. S. Parks, et al. Hepatic ATP-Binding Cassette Transporter A1 Is a Key Molecule in High-Density Lipoprotein Cholesteryl Ester Metabolism in Mice Arterioscler. Thromb. Vasc. Biol., August 1, 2006; 26(8): 1821 - 1827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cuchel and D. J. Rader Macrophage Reverse Cholesterol Transport: Key to the Regression of Atherosclerosis? Circulation, May 30, 2006; 113(21): 2548 - 2555. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Yesilaltay, M. G. Morales, L. Amigo, S. Zanlungo, A. Rigotti, S. L. Karackattu, M. H. Donahee, K. F. Kozarsky, and M. Krieger Effects of Hepatic Expression of the High-Density Lipoprotein Receptor SR-BI on Lipoprotein Metabolism and Female Fertility Endocrinology, April 1, 2006; 147(4): 1577 - 1588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bietrix, D. Yan, M. Nauze, C. Rolland, J. Bertrand-Michel, C. Comera, S. Schaak, R. Barbaras, A. K. Groen, B. Perret, et al. Accelerated Lipid Absorption in Mice Overexpressing Intestinal SR-BI J. Biol. Chem., March 17, 2006; 281(11): 7214 - 7219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Masson, L. Lagrost, A. Athias, P. Gambert, C. Brimer-Cline, L. Lan, J. D. Schuetz, E. G. Schuetz, and M. Assem Expression of the Pregnane X Receptor in Mice Antagonizes the Cholic Acid-Mediated Changes in Plasma Lipoprotein Profile Arterioscler. Thromb. Vasc. Biol., October 1, 2005; 25(10): 2164 - 2169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nakamura, N. Shibata, T. Nishimoto-Shibata, D. Feng, M. Ikemoto, K. Motojima, N. Iso-o, K. Tsukamoto, M. Tsujimoto, and H. Arai Regulation of SR-BI protein levels by phosphorylation of its associated protein, PDZK1 PNAS, September 20, 2005; 102(38): 13404 - 13409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Out, M. Hoekstra, S. C. A. de Jager, P. de Vos, D. R. van der Westhuyzen, N. R. Webb, M. Van Eck, E. A. L. Biessen, and T. J. C. Van Berkel Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice J. Lipid Res., June 1, 2005; 46(6): 1172 - 1181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wustner Mathematical Analysis of Hepatic High Density Lipoprotein Transport Based on Quantitative Imaging Data J. Biol. Chem., February 25, 2005; 280(8): 6766 - 6779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Out, M. Hoekstra, J. A. A. Spijkers, J. K. Kruijt, M. van Eck, I. S. T. Bos, J. Twisk, and T. J. C. Van Berkel Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice J. Lipid Res., November 1, 2004; 45(11): 2088 - 2095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Parathath, M. A. Connelly, R. A. Rieger, S. M. Klein, N. A. Abumrad, M. de la Llera-Moya, C. R. Iden, G. H. Rothblat, and D. L. Williams Changes in Plasma Membrane Properties and Phosphatidylcholine Subspecies of Insect Sf9 Cells Due to Expression of Scavenger Receptor Class B, Type I, and CD36 J. Biol. Chem., October 1, 2004; 279(40): 41310 - 41318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Schwartz, J. M. VandenBroek, and P. S. Cooper Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans J. Lipid Res., September 1, 2004; 45(9): 1594 - 1607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Camarota, J. M. Chapman, D. Y. Hui, and P. N. Howles Carboxyl Ester Lipase Cofractionates with Scavenger Receptor BI in Hepatocyte Lipid Rafts and Enhances Selective Uptake and Hydrolysis of Cholesteryl Esters from HDL3 J. Biol. Chem., June 25, 2004; 279(26): 27599 - 27606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Parathath, D. Sahoo, Y. F. Darlington, Y. Peng, H. L. Collins, G. H. Rothblat, D. L. Williams, and M. A. Connelly Glycine 420 Near the C-terminal Transmembrane Domain of SR-BI Is Critical for Proper Delivery and Metabolism of High Density Lipoprotein Cholesteryl Ester J. Biol. Chem., June 11, 2004; 279(24): 24976 - 24985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wustner, M. Mondal, A. Huang, and F. R. Maxfield Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells J. Lipid Res., March 1, 2004; 45(3): 427 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Trigatti, M. Krieger, and A. Rigotti Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and Atherosclerosis Arterioscler. Thromb. Vasc. Biol., October 1, 2003; 23(10): 1732 - 1738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Sehayek, R. Wang, J. G. Ono, V. S. Zinchuk, E. M. Duncan, S. Shefer, D. E. Vance, M. Ananthanarayanan, B. T. Chait, and J. L. Breslow Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol J. Lipid Res., September 1, 2003; 44(9): 1605 - 1613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Covey, M. Krieger, W. Wang, M. Penman, and B. L. Trigatti Scavenger Receptor Class B Type I-Mediated Protection Against Atherosclerosis in LDL Receptor-Negative Mice Involves Its Expression in Bone Marrow-Derived Cells Arterioscler. Thromb. Vasc. Biol., September 1, 2003; 23(9): 1589 - 1594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Connelly, M. de la Llera-Moya, Y. Peng, D. Drazul-Schrader, G. H. Rothblat, and D. L. Williams Separation of Lipid Transport Functions by Mutations in the Extracellular Domain of Scavenger Receptor Class B, Type I J. Biol. Chem., July 3, 2003; 278(28): 25773 - 25782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. R Gordon, T. S Parker, D. M Levine, S. D Saal, L. C. Hudgins, B.-J. Sloan, C. Chu, K. H Stenzel, and A. L Rubin Safety and Pharmacokinetics of an Endotoxin-Binding Phospholipid Emulsion Ann. Pharmacother., July 1, 2003; 37(7): 943 - 950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Van Eck, J. Twisk, M. Hoekstra, B. T. Van Rij, C. A. C. Van der Lans, I. S. T. Bos, J. K. Kruijt, F. Kuipers, and T. J. C. Van Berkel Differential Effects of Scavenger Receptor BI Deficiency on Lipid Metabolism in Cells of the Arterial Wall and in the Liver J. Biol. Chem., June 20, 2003; 278(26): 23699 - 23705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Braun, S. Zhang, H. E. Miettinen, S. Ebrahim, T. M. Holm, E. Vasile, M. J. Post, D. M. Yoerger, M. H. Picard, J. L. Krieger, et al. Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse PNAS, June 10, 2003; 100(12): 7283 - 7288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rigotti, H. E. Miettinen, and M. Krieger The Role of the High-Density Lipoprotein Receptor SR-BI in the Lipid Metabolism of Endocrine and Other Tissues Endocr. Rev., June 1, 2003; 24(3): 357 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, M. A. Connelly, A. G. Ostermeyer, H.-h. Chen, D. L. Williams, and D. A. Brown Caveolin-1 does not affect SR-BI-mediated cholesterol efflux or selective uptake of cholesteryl ester in two cell lines J. Lipid Res., April 1, 2003; 44(4): 807 - 815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Trauner and J. L. Boyer Bile Salt Transporters: Molecular Characterization, Function, and Regulation Physiol Rev, April 1, 2003; 83(2): 633 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ma, M. Cilingiroglu, J. D. Otvos, C. M. Ballantyne, A. J. Marian, and L. Chan Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism PNAS, March 4, 2003; 100(5): 2748 - 2753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Connelly, G. Kellner-Weibel, G. H. Rothblat, and D. L. Williams SR-BI-directed HDL-cholesteryl ester hydrolysis J. Lipid Res., February 1, 2003; 44(2): 331 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Goldfarb, T. S. Parker, D. M. Levine, D. Glock, I. Akhter, A. Alkhudari, R. J. McCarthy, E. M. David, B. R. Gordon, S. D. Saal, et al. Protein-free phospholipid emulsion treatment improved cardiopulmonary function and survival in porcine sepsis Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R550 - R557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Silver A Carboxyl-terminal PDZ-interacting Domain of Scavenger Receptor B, Type I Is Essential for Cell Surface Expression in Liver J. Biol. Chem., September 6, 2002; 277(37): 34042 - 34047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hyogo, S. Roy, B. Paigen, and D. E. Cohen Leptin Promotes Biliary Cholesterol Elimination during Weight Loss in ob/ob Mice by Regulating the Enterohepatic Circulation of Bile Salts J. Biol. Chem., September 6, 2002; 277(37): 34117 - 34124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Liu and M. Krieger Highly Purified Scavenger Receptor Class B, Type I Reconstituted into Phosphatidylcholine/Cholesterol Liposomes Mediates High Affinity High Density Lipoprotein Binding and Selective Lipid Uptake J. Biol. Chem., September 6, 2002; 277(37): 34125 - 34135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Mendez-Sanchez, V. Gonzalez, A. C. King-Martinez, H. Sanchez, and M. Uribe Plasma Leptin and the Cholesterol Saturation of Bile Are Correlated in Obese Women after Weight Loss J. Nutr., August 1, 2002; 132(8): 2195 - 2198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bouchard, D. Johnson, T. Carver, B. Paigen, and M. C. Carey Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk J. Lipid Res., July 1, 2002; 43(7): 1105 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Tall MIghty Mouse Circ. Res., February 22, 2002; 90(3): 244 - 245. [Full Text] [PDF]
|
|
|
|
|
|
M. Fuchs, A. Hafer, C. Munch, F. Kannenberg, S. Teichmann, J. Scheibner, E. F. Stange, and U. Seedorf Disruption of the Sterol Carrier Protein 2 Gene in Mice Impairs Biliary Lipid and Hepatic Cholesterol Metabolism J. Biol. Chem., December 14, 2001; 276(51): 48058 - 48065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Thuahnai, S. Lund-Katz, D. L. Williams, and M. C. Phillips Scavenger Receptor Class B, Type I-mediated Uptake of Various Lipids into Cells. INFLUENCE OF THE NATURE OF THE DONOR PARTICLE INTERACTION WITH THE RECEPTOR J. Biol. Chem., November 16, 2001; 276(47): 43801 - 43808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Cachefo, P. Boucher, C. Vidon, E. Dusserre, F. Diraison, and M. Beylot Hepatic Lipogenesis and Cholesterol Synthesis in Hyperthyroid Patients J. Clin. Endocrinol. Metab., November 1, 2001; 86(11): 5353 - 5357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Xu, U. Ekstrom, and P. Nilsson-Ehle ACTH Decreases the Expression and Secretion of Apolipoprotein B in HepG2 Cell Cultures J. Biol. Chem., October 12, 2001; 276(42): 38680 - 38684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhou and A. Nilsson Sources of eicosanoid precursor fatty acid pools in tissues J. Lipid Res., October 1, 2001; 42(10): 1521 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-Y. Tu and J. J. Albers Glucose Regulates the Transcription of Human Genes Relevant to HDL Metabolism: Responsive Elements for Peroxisome Proliferator-Activated Receptor Are Involved in the Regulation of Phospholipid Transfer Protein Diabetes, August 1, 2001; 50(8): 1851 - 1856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Cai, R. J. Kirby, P. N. Howles, and D. Y. Hui Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine J. Lipid Res., June 1, 2001; 42(6): 902 - 909. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. K. Garcia, G. Mues, Y. Liao, T. Hyatt, N. Patil, J. C. Cohen, and H. H. Hobbs Sequence Diversity in Genes of Lipid Metabolism Genome Res., June 1, 2001; 11(6): 1043 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Mardones, V. Quiñones, L. Amigo, M. Moreno, J. F. Miquel, M. Schwarz, H. E. Miettinen, B. Trigatti, M. Krieger, S. VanPatten, et al. Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice J. Lipid Res., February 1, 2001; 42(2): 170 - 180. [Abstract] [Full Text]
|
|
|
|
|
|
K. N. Liadaki, T. Liu, S. Xu, B. Y. Ishida, P. N. Duchateaux, J. P. Krieger, J. Kane, M. Krieger, and V. I. Zannis Binding of High Density Lipoprotein (HDL) and Discoidal Reconstituted HDL to the HDL Receptor Scavenger Receptor Class B Type I. EFFECT OF LIPID ASSOCIATION AND APOA-I MUTATIONS ON RECEPTOR BINDING J. Biol. Chem., July 7, 2000; 275(28): 21262 - 21271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, D. L. Silver, J. D. Smith, and A. R. Tall Scavenger Receptor-BI Inhibits ATP-binding Cassette Transporter 1- mediated Cholesterol Efflux in Macrophages J. Biol. Chem., September 29, 2000; 275(40): 30794 - 30800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Yancey, M. de la Llera-Moya, S. Swarnakar, P. Monzo, S. M. Klein, M. A. Connelly, W. J. Johnson, D. L. Williams, and G. H. Rothblat High Density Lipoprotein Phospholipid Composition Is a Major Determinant of the Bi-directional Flux and Net Movement of Cellular Free Cholesterol Mediated by Scavenger Receptor BI J. Biol. Chem., November 17, 2000; 275(47): 36596 - 36604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ohgami, R. Nagai, A. Miyazaki, M. Ikemoto, H. Arai, S. Horiuchi, and H. Nakayama Scavenger Receptor Class B Type I-mediated Reverse Cholesterol Transport Is Inhibited by Advanced Glycation End Products J. Biol. Chem., April 13, 2001; 276(16): 13348 - 13355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Silver, N. Wang, X. Xiao, and A. R. Tall High Density Lipoprotein (HDL) Particle Uptake Mediated by Scavenger Receptor Class B Type 1 Results in Selective Sorting of HDL Cholesterol from Protein and Polarized Cholesterol Secretion J. Biol. Chem., June 29, 2001; 276(27): 25287 - 25293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-P. Liang and A. R. Tall Transcriptional Profiling Reveals Global Defects in Energy Metabolism, Lipoprotein, and Bile Acid Synthesis and Transport with Reversal by Leptin Treatment in Ob/ob Mouse Liver J. Biol. Chem., December 21, 2001; 276(52): 49066 - 49076. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
