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J Biol Chem, Vol. 274, Issue 47, 33785-33789, November 19, 1999

An Unexpected Link between the Secretory Path and the Organization of the Nucleus

Jayasri Nanduri, Srabani Mitra, Christina Andrei, Yan Liu, Yihong Yu, Midori Hitomi, and Alan M. Tartakoff

From the Department of Pathology and Cell Biology Program, Case Western Reserve University, Cleveland, Ohio 44106

Yeast sec mutations define the machinery of vesicular traffic. Surprisingly, many of these mutations also inhibit ribosome biogenesis by reducing transcription of rRNA and genes encoding ribosomal proteins. We observe that these mutants reversibly inhibit protein import into the nucleus, with import cargo accumulating at the nucleoplasmic face of nuclear pore complexes, as when Ran-GTP cannot bind importins. They also rapidly and reversibly relocate multiple nucleolar and nucleoplasmic proteins to the cytoplasm. The import block and relocation are antagonized by overexpression of yeast Ran, Hog1p kinase, or Ssa/Hsp70 proteins or by inhibition of protein synthesis. These nucleocytoplasmic signaling events document an extraordinary plasticity of nuclear organization.

Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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