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J Biol Chem, Vol. 274, Issue 48, 33859-33862, November 26, 1999

COMMUNICATION
Mouse Cyclin-dependent Kinase (Cdk) 5 Is a Functional Homologue of a Yeast Cdk, Pho85 Kinase

Masafumi Nishizawa, Yuko Kanaya, and Akio Toh-e^¶

From the  Department of Microbiology, Keio University School of Medicine, Shinjuku, Tokyo 160-8582 and the ^¶ Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo 113-0033, Japan

Mouse cyclin-dependent kinase (Cdk) 5 and yeast Pho85 kinase share similarities in structure as well as in the regulation of their activity. We found that mouse Cdk5 kinase produced in pho85 mutant cells could suppress some of pho85 mutant phenotypes including failure to grow on nonfermentable carbon sources, morphological defects, and growth defect caused by Pho4 or Clb2 overproduction. We also demonstrated that Cdk5 coimmunoprecipitated with Pho85-cyclins including Pcl1, Pcl2, Pcl6, Pcl9, and Pho80, and that the immunocomplex could phosphorylate Pho4, a native substrate of Pho85 kinase. Thus mouse Cdk5 is a functional homologue of yeast Pho85 kinase.

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