| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 48, 34301-34309, November 26, 1999
From the Department of Pathology, Division of Molecular and
Cellular Pathology, University of Alabama at Birmingham,
Birmingham, Alabama 35294-0019
Vascular smooth muscle cells (VSMC) exist in
either a contractile or a synthetic phenotype in vitro and
in vivo. The molecular mechanisms regulating phenotypic
modulation are unknown. Previous studies have suggested that the
serine/threonine protein kinase mediator of nitric oxide (NO) and
cyclic GMP (cGMP) signaling, the cGMP-dependent protein
kinase (PKG) promotes modulation to the contractile phenotype in
cultured rat aortic smooth muscle cells (RASMC). Because of the
potential importance of the mitogen-activated protein kinase (MAP
kinase) pathways in VSMC proliferation and phenotypic modulation, the
effects of PKG expression in PKG-deficient and PKG-expressing adult
RASMC on MAP kinases were examined. In PKG-expressing adult RASMC,
8-para-chlorophenylthio-cGMP activated extracellular
signal- regulated kinases (ERK1/2) and c-Jun N-terminal kinase (JNK).
The major effect of PKG activation was increased activation by MAP
kinase kinase (MEK). The cAMP analog, 8-Br-cAMP inhibited ERK1/2
activation in PKG-deficient and PKG-expressing RASMC but had no effect
on JNK activity. The effects of PKG on ERK and JNK activity were
additive with those of platelet-derived growth factor (PDGF),
suggesting that PKG activates MEK through a pathway not used by PDGF.
The stimulatory effects of cGMP on ERK and JNK activation were also
observed in low-passaged, contractile RASMC still expressing endogenous
PKG, suggesting that the effects of PKG expression were not artifacts
of cell transfections. These results suggest that in contractile adult
RASMC, NO-cGMP signaling increases MAP kinase activity. Increased
activation of these MAP kinase pathways may be one mechanism by which
cGMP and PKG activation mediate c-fos induction and
increased proliferation of contractile adult RASMC.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Z. Yuan, T. W. Hein, R. H. Rosa Jr, and L. Kuo Sildenafil (Viagra) Evokes Retinal Arteriolar Dilation: Dual Pathways via NOS Activation and Phosphodiesterase Inhibition Invest. Ophthalmol. Vis. Sci., February 1, 2008; 49(2): 720 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Das, A. Smolenski, S. M. Lohmann, and R. C. Kukreja Cyclic GMP-dependent Protein Kinase I{alpha} Attenuates Necrosis and Apoptosis Following Ischemia/Reoxygenation in Adult Cardiomyocyte J. Biol. Chem., December 15, 2006; 281(50): 38644 - 38652. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nigro, N. Osman, A. M. Dart, and P. J. Little Insulin Resistance and Atherosclerosis Endocr. Rev., May 1, 2006; 27(3): 242 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Li, G. Zhang, R. Feil, J. Han, and X. Du Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin {alpha}IIbbeta3 Blood, February 1, 2006; 107(3): 965 - 972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Hofmann, R. Feil, T. Kleppisch, and J. Schlossmann Function of cGMP-Dependent Protein Kinases as Revealed by Gene Deletion Physiol Rev, January 1, 2006; 86(1): 1 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G. Werner, V. Godfrey, R. R. Arnold, G. L. Featherstone, D. Bender, J. Schlossmann, M. Schiemann, F. Hofmann, and K. B. Pryzwansky Neutrophil Dysfunction in Guanosine 3',5'-Cyclic Monophosphate-Dependent Protein Kinase I-Deficient Mice J. Immunol., August 1, 2005; 175(3): 1919 - 1929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Teng, W. Qin, H. R. Ansari, and S. J. Mustafa Involvement of p38-mitogen-activated protein kinase in adenosine receptor-mediated relaxation of coronary artery Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2574 - H2580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Gonzalez-Flores, J. Shu, I. Camacho-Arroyo, and A. M. Etgen Regulation of Lordosis by Cyclic 3',5'-Guanosine Monophosphate, Progesterone, and Its 5{alpha}-Reduced Metabolites Involves Mitogen-Activated Protein Kinase Endocrinology, December 1, 2004; 145(12): 5560 - 5567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-M. Yang, J. B. Proctor, L. Cui, T. Krieg, J. M. Downey, and M. V. Cohen Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways J. Am. Coll. Cardiol., September 1, 2004; 44(5): 1103 - 1110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mizuno, M. Kadowaki, Y. Demura, S. Ameshima, I. Miyamori, and T. Ishizaki p42/44 Mitogen-Activated Protein Kinase Regulated by p53 and Nitric Oxide in Human Pulmonary Arterial Smooth Muscle Cells Am. J. Respir. Cell Mol. Biol., August 1, 2004; 31(2): 184 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Shih, S. Zhang, H. J. Cao, H.-Y. Tang, F. B. Davis, P. J. Davis, and H.-Y. Lin Disparate Effects of Thyroid Hormone on Actions of Epidermal Growth Factor and Transforming Growth Factor-{alpha} Are Mediated by 3',5'-Cyclic Adenosine 5'-Monophosphate-Dependent Protein Kinase II Endocrinology, April 1, 2004; 145(4): 1708 - 1717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Pilz and D. E. Casteel Regulation of Gene Expression by Cyclic GMP Circ. Res., November 28, 2003; 93(11): 1034 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Feil, S. M. Lohmann, H. de Jonge, U. Walter, and F. Hofmann Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System: Insights From Genetically Modified Mice Circ. Res., November 14, 2003; 93(10): 907 - 916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dixit, D. Zhuang, B. Ceacareanu, and A. Hassid Treatment With Insulin Uncovers the Motogenic Capacity of Nitric Oxide in Aortic Smooth Muscle Cells: Dependence on Gab1 and Gab1-SHP2 Association Circ. Res., November 14, 2003; 93 (10): e113 - e123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Li, J. Ajdic, M. Eigenthaler, and X. Du A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans Blood, June 1, 2003; 101(11): 4423 - 4429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hou, J. Lascola, N. O. Dulin, R. D. Ye, and D. D. Browning Activation of cGMP-dependent Protein Kinase by Protein Kinase C J. Biol. Chem., May 2, 2003; 278(19): 16706 - 16712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Di Fulvio, P. K. Lauf, S. Shah, and N. C. Adragna NONOates regulate KCl cotransporter-1 and -3 mRNA expression in vascular smooth muscle cells Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1686 - H1692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. M. Bon and J. Garthwaite On the Role of Nitric Oxide in Hippocampal Long-Term Potentiation J. Neurosci., March 1, 2003; 23(5): 1941 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pedram, M. Razandi, and E. R. Levin Deciphering Vascular Endothelial Cell Growth Factor/Vascular Permeability Factor Signaling to Vascular Permeability. INHIBITION BY ATRIAL NATRIURETIC PEPTIDE J. Biol. Chem., November 8, 2002; 277(46): 44385 - 44398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zaragoza, E. Soria, E. Lopez, D. Browning, M. Balbin, C. Lopez-Otin, and S. Lamas Activation of the Mitogen Activated Protein Kinase Extracellular Signal-Regulated Kinase 1 and 2 by the Nitric Oxide-cGMP-cGMP-Dependent Protein Kinase Axis Regulates the Expression of Matrix Metalloproteinase 13 in Vascular Endothelial Cells Mol. Pharmacol., October 1, 2002; 62(4): 927 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gudi, J. C. Chen, D. E. Casteel, T. M. Seasholtz, G. R. Boss, and R. B. Pilz cGMP-dependent Protein Kinase Inhibits Serum-response Element-dependent Transcription by Inhibiting Rho Activation and Functions J. Biol. Chem., September 27, 2002; 277(40): 37382 - 37393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chang, B. Ceacareanu, M. Dixit, N. Sreejayan, and A. Hassid Nitric Oxide-Induced Motility in Aortic Smooth Muscle Cells: Role of Protein Tyrosine Phosphatase SHP-2 and GTP-Binding Protein Rho Circ. Res., September 6, 2002; 91(5): 390 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Komatsu, K. Miyazaki, R. A. Tuft, and M. Ikebe Translocation of telokin by cGMP signaling in smooth muscle cells Am J Physiol Cell Physiol, September 1, 2002; 283(3): C752 - C761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Leach, S. M. Black, R. K. Schmidt-Ullrich, and R. B. Mikkelsen Activation of Constitutive Nitric-oxide Synthase Activity Is an Early Signaling Event Induced by Ionizing Radiation J. Biol. Chem., May 3, 2002; 277(18): 15400 - 15406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takuma, P. Phuagphong, E. Lee, K. Mori, A. Baba, and T. Matsuda Anti-apoptotic Effect of cGMP in Cultured Astrocytes. INHIBITION BY cGMP-DEPENDENT PROTEIN KINASE OF MITOCHONDRIAL PERMEABLE TRANSITION PORE J. Biol. Chem., December 14, 2001; 276(51): 48093 - 48099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Li, X. Xi, and X. Du A Mitogen-activated Protein Kinase-dependent Signaling Pathway in the Activation of Platelet Integrin alpha IIbbeta 3 J. Biol. Chem., November 2, 2001; 276(45): 42226 - 42232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Liu, H. Li, T. Underwood, M. Lloyd, M. David, G. Sperl, R. Pamukcu, and W. J. Thompson Cyclic GMP-Dependent Protein Kinase Activation and Induction by Exisulind and CP461 in Colon Tumor Cells J. Pharmacol. Exp. Ther., November 1, 2001; 299(2): 583 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Dudek and J. G. N. Garcia Cytoskeletal regulation of pulmonary vascular permeability J Appl Physiol, October 1, 2001; 91(4): 1487 - 1500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Ratz Regulation of ERK phosphorylation in differentiated arterial muscle of rabbits Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H114 - H123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Abdel-Latif Cross Talk Between Cyclic Nucleotides and Polyphosphoinositide Hydrolysis, Protein Kinases, and Contraction in Smooth Muscle Experimental Biology and Medicine, March 1, 2001; 226(3): 153 - 163. [Abstract] [Full Text]
|
|
|
|
|
|
R. P. Cherla and R. K. Ganju Stromal Cell-Derived Factor 1{{alpha}}-Induced Chemotaxis in T Cells Is Mediated by Nitric Oxide Signaling Pathways J. Immunol., March 1, 2001; 166(5): 3067 - 3074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Ho and C. L. Chik Adrenergic Regulation of Mitogen-Activated Protein Kinase in Rat Pinealocytes: Opposing Effects of Protein Kinase A and Protein Kinase G Endocrinology, December 1, 2000; 141(12): 4496 - 4502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Quinlan, D. Li, V. E. Laubach, E. G. Shesely, N. Zhou, and R. A. Johns eNOS-deficient mice show reduced pulmonary vascular proliferation and remodeling to chronic hypoxia Am J Physiol Lung Cell Mol Physiol, October 1, 2000; 279(4): L641 - L650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Roberts Jr, J.-D. Chiche, J. Weimann, W. Steudel, W. M. Zapol, and K. D. Bloch Nitric Oxide Inhalation Decreases Pulmonary Artery Remodeling in the Injured Lungs of Rat Pups Circ. Res., July 21, 2000; 87(2): 140 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Wolin Interactions of Oxidants With Vascular Signaling Systems Arterioscler. Thromb. Vasc. Biol., June 1, 2000; 20(6): 1430 - 1442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Burkhardt, M. Glazova, S. Gambaryan, T. Vollkommer, E. Butt, B. Bader, K. Heermeier, T. M. Lincoln, U. Walter, and A. Palmetshofer KT5823 Inhibits cGMP-dependent Protein Kinase Activity in Vitro but Not in Intact Human Platelets and Rat Mesangial Cells J. Biol. Chem., October 20, 2000; 275(43): 33536 - 33541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Xia, Z. Bao, C. Yue, B. M. Sanborn, and M. Liu Phosphorylation and Regulation of G-protein-activated Phospholipase C-beta 3 by cGMP-dependent Protein Kinases J. Biol. Chem., June 1, 2001; 276(23): 19770 - 19777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Fischer, A. Palmetshofer, S. Gambaryan, E. Butt, C. Jassoy, U. Walter, S. Sopper, and S. M. Lohmann Activation of cGMP-dependent Protein Kinase Ibeta Inhibits Interleukin 2 Release and Proliferation of T Cell Receptor-stimulated Human Peripheral T Cells J. Biol. Chem., February 16, 2001; 276(8): 5967 - 5974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Di Fulvio, T. M. Lincoln, P. K. Lauf, and N. C. Adragna Protein Kinase G Regulates Potassium Chloride Cotransporter-3 Expression in Primary Cultures of Rat Vascular Smooth Muscle Cells J. Biol. Chem., June 8, 2001; 276(24): 21046 - 21052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Di Fulvio, P. K. Lauf, and N. C. Adragna Nitric Oxide Signaling Pathway Regulates Potassium Chloride Cotransporter-1 mRNA Expression in Vascular Smooth Muscle Cells J. Biol. Chem., November 21, 2001; 276(48): 44534 - 44540. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
