| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 50, 35832-35839, December 10, 1999
,
From the Department of Metabolic Diseases, Faculty of Medicine,
University of Tokyo, Tokyo 113-8655, Japan
To elucidate the physiological role of sterol
regulatory element-binding protein-1 (SREBP-1), the hepatic mRNA
levels of genes encoding various lipogenic enzymes were estimated in
SREBP-1 gene knockout mice after a fasting-refeeding treatment, which
is an established dietary manipulation for the induction of lipogenic enzymes. In the fasted state, the mRNA levels of all lipogenic enzymes were consistently low in both wild-type and
SREBP-1
/ mice. However, the absence of
SREBP-1 severely impaired the marked induction of hepatic mRNAs of
fatty acid synthetic genes, such as acetyl-CoA carboxylase, fatty acid
synthase, and stearoyl-CoA desaturase, that was observed upon refeeding
in the wild-type mice. Furthermore, the refeeding responses of other
lipogenic enzymes, glycerol-3-phosphate acyltransferase, ATP citrate
lyase, malic enzyme, glucose-6-phosphate dehydrogenase, and S14
mRNAs, were completely abolished in
SREBP-1/ mice. In contrast, mRNA levels
for cholesterol biosynthetic genes were elevated in the refed
SREBP-1/ livers accompanied by an increase
in nuclear SREBP-2 protein. When fed a high carbohydrate diet for 14 days, the mRNA levels for these lipogenic enzymes were also
strikingly lower in SREBP-1/ mice than
those in wild-type mice. These data demonstrate that SREBP-1 plays a
crucial role in the induction of lipogenesis but not cholesterol
biosynthesis in liver when excess energy by carbohydrates is consumed.
To whom correspondence should be addressed: 7-3-1 Hongo,
Bunkyo-ku, Tokyo, 113-8655, Japan. Tel.: 81-3-3815-5411 (ext. 33113); Fax: 81-3-5802-2955; E-mail: shimano-tky@umin.ac.jp.
§
Recipient of a fellowship under the Japan Society for the Promotion
of Science Postdoctoral Fellowship Program for Foreign Researchers.
¶
Present address: Division of Endocrinology and Metabolism,
Dept. of Internal Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
This article has been cited by other articles:
|
|
 |
|
  A. Roth, R. Looser, M. Kaufmann, S. M. Blattler, F. Rencurel, W. Huang, D. D. Moore, and U. A. Meyer Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression Mol. Pharmacol., April 1, 2008; 73(4): 1282 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. E. Rasmussen, K. R. Blobaum, Y.-K. Park, S. J. Ehlers, F. Lu, and J.-Y. Lee Lipid Extract of Nostoc commune var. sphaeroides Kutzing, a Blue-Green Alga, Inhibits the Activation of Sterol Regulatory Element Binding Proteins in HepG2 Cells J. Nutr., March 1, 2008; 138(3): 476 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Jeong, H.-S. Lee, K.-S. Kim, Y.-K. Kim, D. Yoon, and S. W. Park Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2 J. Lipid Res., February 1, 2008; 49(2): 399 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. T. Wunderlich, T. Luedde, S. Singer, M. Schmidt-Supprian, J. Baumgartl, P. Schirmacher, M. Pasparakis, and J. C. Bruning Hepatic NF-{kappa}B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis PNAS, January 29, 2008; 105(4): 1297 - 1302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, A. Nanayakkara, J. Jun, V. Savransky, and V. Y. Polotsky Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia Physiol Genomics, October 19, 2007; 31(2): 273 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sekiya, N. Yahagi, T. Matsuzaka, Y. Takeuchi, Y. Nakagawa, H. Takahashi, H. Okazaki, Y. Iizuka, K. Ohashi, T. Gotoda, et al. SREBP-1-independent regulation of lipogenic gene expression in adipocytes J. Lipid Res., July 1, 2007; 48(7): 1581 - 1591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Schroeder-Gloeckler, S. M. Rahman, R. C. Janssen, L. Qiao, J. Shao, M. Roper, S. J. Fischer, E. Lowe, D. J. Orlicky, J. L. McManaman, et al. CCAAT/Enhancer-binding Protein beta Deletion Reduces Adiposity, Hepatic Steatosis, and Diabetes in Leprdb/db Mice J. Biol. Chem., May 25, 2007; 282(21): 15717 - 15729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamamoto, H. Shimano, N. Inoue, Y. Nakagawa, T. Matsuzaka, A. Takahashi, N. Yahagi, H. Sone, H. Suzuki, H. Toyoshima, et al. Protein Kinase A Suppresses Sterol Regulatory Element-binding Protein-1C Expression via Phosphorylation of Liver X Receptor in the Liver J. Biol. Chem., April 20, 2007; 282(16): 11687 - 11695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Beyea, C. L. Heslop, C. G. Sawyez, J. Y. Edwards, J. G. Markle, R. A. Hegele, and M. W. Huff Selective Up-regulation of LXR-regulated Genes ABCA1, ABCG1, and APOE in Macrophages through Increased Endogenous Synthesis of 24(S),25-Epoxycholesterol J. Biol. Chem., February 23, 2007; 282(8): 5207 - 5216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Griffin, R. H. F. Wong, N. Pandya, and H. S. Sul Direct Interaction between USF and SREBP-1c Mediates Synergistic Activation of the Fatty-acid Synthase Promoter J. Biol. Chem., February 23, 2007; 282(8): 5453 - 5467. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Higami, T. Tsuchiya, T. Chiba, H. Yamaza, I. Muraoka, M. Hirose, T. Komatsu, and I. Shimokawa Hepatic Gene Expression Profile of Lipid Metabolism in Rats: Impact of Caloric Restriction and Growth Hormone/Insulin-Like Growth Factor-1 Suppression J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2006; 61(11): 1099 - 1110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. da Silva Xavier, G. A. Rutter, F. Diraison, C. Andreolas, and I. Leclerc ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic {beta}-cells J. Lipid Res., November 1, 2006; 47(11): 2482 - 2491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hoekstra, M. Stitzinger, E. J. A. van Wanrooij, I. N. Michon, J. K. Kruijt, J. Kamphorst, M. Van Eck, E. Vreugdenhil, T. J. C. Van Berkel, and J. Kuiper Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet J. Lipid Res., October 1, 2006; 47(10): 2198 - 2207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ma, L. N. Robinson, and H. C. Towle ChREBP*Mlx Is the Principal Mediator of Glucose-induced Gene Expression in the Liver J. Biol. Chem., September 29, 2006; 281(39): 28721 - 28730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Meton, M. Egea, I. G. Anemaet, F. Fernandez, and I. V. Baanante Sterol Regulatory Element Binding Protein-1a Transactivates 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase Gene Promoter Endocrinology, July 1, 2006; 147(7): 3446 - 3456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhou, Y. Zhai, Y. Mu, H. Gong, H. Uppal, D. Toma, S. Ren, R. M. Evans, and W. Xie A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway J. Biol. Chem., May 26, 2006; 281(21): 15013 - 15020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, M. Bosch-Marce, A. Nanayakkara, V. Savransky, S. K. Fried, G. L. Semenza, and V. Y. Polotsky Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1{alpha} Physiol Genomics, May 16, 2006; 25(3): 450 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Costet, B. Cariou, G. Lambert, F. Lalanne, B. Lardeux, A.-L. Jarnoux, A. Grefhorst, B. Staels, and M. Krempf Hepatic PCSK9 Expression Is Regulated by Nutritional Status via Insulin and Sterol Regulatory Element-binding Protein 1c J. Biol. Chem., March 10, 2006; 281(10): 6211 - 6218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, D. N. Grigoryev, S. Q. Ye, L. Thorne, A. R. Schwartz, P. L. Smith, C. P. O'Donnell, and V. Y. Polotsky Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice J Appl Physiol, November 1, 2005; 99(5): 1643 - 1648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Inoue, H. Shimano, M. Nakakuki, T. Matsuzaka, Y. Nakagawa, T. Yamamoto, R. Sato, A. Takahashi, H. Sone, N. Yahagi, et al. Lipid Synthetic Transcription Factor SREBP-1a Activates p21WAF1/CIP1, a Universal Cyclin-Dependent Kinase Inhibitor Mol. Cell. Biol., October 15, 2005; 25(20): 8938 - 8947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Amemiya-Kudo, J. Oka, T. Ide, T. Matsuzaka, H. Sone, T. Yoshikawa, N. Yahagi, S. Ishibashi, J.-i. Osuga, N. Yamada, et al. Sterol Regulatory Element-binding Proteins Activate Insulin Gene Promoter Directly and Indirectly through Synergy with BETA2/E47 J. Biol. Chem., October 14, 2005; 280(41): 34577 - 34589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Najima, N. Yahagi, Y. Takeuchi, T. Matsuzaka, M. Sekiya, Y. Nakagawa, M. Amemiya-Kudo, H. Okazaki, S. Okazaki, Y. Tamura, et al. High Mobility Group Protein-B1 Interacts with Sterol Regulatory Element-binding Proteins to Enhance Their DNA Binding J. Biol. Chem., July 29, 2005; 280(30): 27523 - 27532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lemieux, Y. Gelinas, J. Lalonde, F. Labrie, K. Cianflone, and Y. Deshaies Hypolipidemic action of the SERM acolbifene is associated with decreased liver MTP and increased SR-BI and LDL receptors J. Lipid Res., June 1, 2005; 46(6): 1285 - 1294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-S. Im, S.-Y. Kang, S.-Y. Kim, H.-i. Kim, J.-W. Kim, K.-S. Kim, and Y.-H. Ahn Glucose-Stimulated Upregulation of GLUT2 Gene Is Mediated by Sterol Response Element-Binding Protein-1c in the Hepatocytes Diabetes, June 1, 2005; 54(6): 1684 - 1691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. MacLean A peripheral perspective of weight regain Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1447 - R1449. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Werner, R. Havinga, T. Bos, V. W. Bloks, F. Kuipers, and H. J. Verkade Essential fatty acid deficiency in mice is associated with hepatic steatosis and secretion of large VLDL particles Am J Physiol Gastrointest Liver Physiol, June 1, 2005; 288(6): G1150 - G1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Gosmain, N. Dif, V. Berbe, E. Loizon, J. Rieusset, H. Vidal, and E. Lefai Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues J. Lipid Res., April 1, 2005; 46(4): 697 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ma, N. G. Tsatsos, and H. C. Towle Direct Role of ChREBP{middle dot}Mlx in Regulating Hepatic Glucose-responsive Genes J. Biol. Chem., March 25, 2005; 280(12): 12019 - 12027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Sandberg, M. Bloksgaard, D. Duran-Sandoval, C. Duval, B. Staels, and S. Mandrup The Gene Encoding Acyl-CoA-binding Protein Is Subject to Metabolic Regulation by Both Sterol Regulatory Element-binding Protein and Peroxisome Proliferator-activated Receptor {alpha} in Hepatocytes J. Biol. Chem., February 18, 2005; 280(7): 5258 - 5266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Suzuki, K. Tobe, M. Aoyama, K. Sakamoto, M. Ohsugi, N. Kamei, S. Nemoto, A. Inoue, Y. Ito, S. Uchida, et al. Expression of DGAT2 in White Adipose Tissue Is Regulated by Central Leptin Action J. Biol. Chem., February 4, 2005; 280(5): 3331 - 3337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Takahashi, K. Motomura, T. Kato, T. Yoshikawa, Y. Nakagawa, N. Yahagi, H. Sone, H. Suzuki, H. Toyoshima, N. Yamada, et al. Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic {beta}-Cells Diabetes, February 1, 2005; 54(2): 492 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kabir, K. J. Catalano, S. Ananthnarayan, S. P. Kim, G. W. Van Citters, M. K. Dea, and R. N. Bergman Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance Am J Physiol Endocrinol Metab, February 1, 2005; 288(2): E454 - E461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Hegarty, A. Bobard, I. Hainault, P. Ferre, P. Bossard, and F. Foufelle From The Cover: Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory elementbinding protein-1c PNAS, January 18, 2005; 102(3): 791 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Matsusue, O. Gavrilova, G. Lambert, H. B. Brewer Jr., J. M. Ward, Y. Inoue, D. LeRoith, and F. J. Gonzalez Hepatic CCAAT/Enhancer Binding Protein {alpha} Mediates Induction of Lipogenesis and Regulation of Glucose Homeostasis in Leptin-Deficient Mice Mol. Endocrinol., November 1, 2004; 18(11): 2751 - 2764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jakel, M. Nowak, E. Moitrot, H. Dehondt, D. W. Hum, L. A. Pennacchio, J. Fruchart-Najib, and J.-C. Fruchart The Liver X Receptor Ligand T0901317 Down-regulates APOA5 Gene Expression through Activation of SREBP-1c J. Biol. Chem., October 29, 2004; 279(44): 45462 - 45469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang and F. B. Hillgartner Starvation and Feeding a High-Carbohydrate, Low-Fat Diet Regulate the Expression Sterol Regulatory Element-Binding Protein-1 in Chickens J. Nutr., September 1, 2004; 134(9): 2205 - 2210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Kim, H.-i. Kim, T.-H. Kim, S.-S. Im, S.-K. Park, I.-K. Lee, K.-S. Kim, and Y.-H. Ahn SREBP-1c Mediates the Insulin-dependent Hepatic Glucokinase Expression J. Biol. Chem., July 16, 2004; 279(29): 30823 - 30829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Commerford, L. Peng, J. J. Dube, and R. M. O'Doherty In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R218 - R227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Miyazaki, A. Dobrzyn, W. C. Man, K. Chu, H. Sampath, H.-J. Kim, and J. M. Ntambi Stearoyl-CoA Desaturase 1 Gene Expression Is Necessary for Fructose-mediated Induction of Lipogenic Gene Expression by Sterol Regulatory Element-binding Protein-1c-dependent and -independent Mechanisms J. Biol. Chem., June 11, 2004; 279(24): 25164 - 25171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G Taylor and P. Zahradka Dietary conjugated linoleic acid and insulin sensitivity and resistance in rodent models Am. J. Clinical Nutrition, June 1, 2004; 79(6): 1164S - 1168S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Lin, J. J. Loor, and J. H. Herbein Trans10,cis12-18:2 Is a More Potent Inhibitor of De Novo Fatty Acid Synthesis and Desaturation than cis9,trans11-18:2 in the Mammary Gland of Lactating Mice J. Nutr., June 1, 2004; 134(6): 1362 - 1368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yahagi, H. Shimano, T. Matsuzaka, M. Sekiya, Y. Najima, S. Okazaki, H. Okazaki, Y. Tamura, Y. Iizuka, N. Inoue, et al. p53 Involvement in the Pathogenesis of Fatty Liver Disease J. Biol. Chem., May 14, 2004; 279(20): 20571 - 20575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dentin, J.-P. Pegorier, F. Benhamed, F. Foufelle, P. Ferre, V. Fauveau, M. A. Magnuson, J. Girard, and C. Postic Hepatic Glucokinase Is Required for the Synergistic Action of ChREBP and SREBP-1c on Glycolytic and Lipogenic Gene Expression J. Biol. Chem., May 7, 2004; 279(19): 20314 - 20326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Paterson, N. M. Morton, C. Fievet, C. J. Kenyon, M. C. Holmes, B. Staels, J. R. Seckl, and J. J. Mullins Metabolic syndrome without obesity: Hepatic overexpression of 11{beta}-hydroxysteroid dehydrogenase type 1 in transgenic mice PNAS, May 4, 2004; 101(18): 7088 - 7093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Seo, H. M. Moon, W. S. Kim, Y. S. Lee, H. W. Jeong, E. J. Yoo, J. Ham, H. Kang, M.-G. Park, K. R. Steffensen, et al. Activated Liver X Receptors Stimulate Adipocyte Differentiation through Induction of Peroxisome Proliferator-Activated Receptor {gamma} Expression Mol. Cell. Biol., April 15, 2004; 24(8): 3430 - 3444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamamoto, H. Shimano, Y. Nakagawa, T. Ide, N. Yahagi, T. Matsuzaka, M. Nakakuki, A. Takahashi, H. Suzuki, H. Sone, et al. SREBP-1 Interacts with Hepatocyte Nuclear Factor-4{alpha} and Interferes with PGC-1 Recruitment to Suppress Hepatic Gluconeogenic Genes J. Biol. Chem., March 26, 2004; 279(13): 12027 - 12035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Beigneux, C. Kosinski, B. Gavino, J. D. Horton, W. C. Skarnes, and S. G. Young ATP-Citrate Lyase Deficiency in the Mouse J. Biol. Chem., March 5, 2004; 279(10): 9557 - 9564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsuzaka, H. Shimano, N. Yahagi, M. Amemiya-Kudo, H. Okazaki, Y. Tamura, Y. Iizuka, K. Ohashi, S. Tomita, M. Sekiya, et al. Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice Diabetes, March 1, 2004; 53(3): 560 - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ascencio, N. Torres, F. Isoard-Acosta, F. J. Gomez-Perez, R. Hernandez-Pando, and A. R. Tovar Soy Protein Affects Serum Insulin and Hepatic SREBP-1 mRNA and Reduces Fatty Liver in Rats J. Nutr., March 1, 2004; 134(3): 522 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Brandsch, N. Nass, and K. Eder A Thermally Oxidized Dietary Oil Does Not Lower the Activities of Lipogenic Enzymes in Mammary Glands of Lactating Rats but Reduces the Milk Triglyceride Concentration J. Nutr., March 1, 2004; 134(3): 631 - 636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Ng, C. Xie, G. F. Maguire, X. Zhu, F. Ugwu, E. Lam, and P. W. Connelly Hypertriglyceridemia in Lecithin-cholesterol Acyltransferase-deficient Mice Is Associated with Hepatic Overproduction of Triglycerides, Increased Lipogenesis, and Improved Glucose Tolerance J. Biol. Chem., February 27, 2004; 279(9): 7636 - 7642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Latasa, M. J. Griffin, Y. S. Moon, C. Kang, and H. S. Sul Occupancy and Function of the -150 Sterol Regulatory Element and -65 E-Box in Nutritional Regulation of the Fatty Acid Synthase Gene in Living Animals Mol. Cell. Biol., August 15, 2003; 23(16): 5896 - 5907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yahagi, H. Shimano, T. Matsuzaka, Y. Najima, M. Sekiya, Y. Nakagawa, T. Ide, S. Tomita, H. Okazaki, Y. Tamura, et al. p53 Activation in Adipocytes of Obese Mice J. Biol. Chem., July 3, 2003; 278(28): 25395 - 25400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yoshikawa, T. Ide, H. Shimano, N. Yahagi, M. Amemiya-Kudo, T. Matsuzaka, S. Yatoh, T. Kitamine, H. Okazaki, Y. Tamura, et al. Cross-Talk between Peroxisome Proliferator-Activated Receptor (PPAR) {alpha} and Liver X Receptor (LXR) in Nutritional Regulation of Fatty Acid Metabolism. I. PPARs Suppress Sterol Regulatory Element Binding Protein-1c Promoter through Inhibition of LXR Signaling Mol. Endocrinol., July 1, 2003; 17(7): 1240 - 1254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ide, H. Shimano, T. Yoshikawa, N. Yahagi, M. Amemiya-Kudo, T. Matsuzaka, M. Nakakuki, S. Yatoh, Y. Iizuka, S. Tomita, et al. Cross-Talk between Peroxisome Proliferator-Activated Receptor (PPAR) {alpha} and Liver X Receptor (LXR) in Nutritional Regulation of Fatty Acid Metabolism. II. LXRs Suppress Lipid Degradation Gene Promoters through Inhibition of PPAR Signaling Mol. Endocrinol., July 1, 2003; 17(7): 1255 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vecchini, V. Ceccarelli, P. Orvietani, P. Caligiana, F. Susta, L. Binaglia, G. Nocentini, C. Riccardi, and P. Di Nardo Enhanced expression of hepatic lipogenic enzymes in an animal model of sedentariness J. Lipid Res., April 1, 2003; 44(4): 696 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Richards, S. M. Poch, C. N. Coon, R. W. Rosebrough, C. M. Ashwell, and J. P. McMurtry Feed Restriction Significantly Alters Lipogenic Gene Expression in Broiler Breeder Chickens J. Nutr., March 1, 2003; 133(3): 707 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
|
