|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 53, 37982-37989, December 31, 1999
From the Department of Physiology and Biophysics, College of
Medicine, University of Illinois, Chicago, Illinois 60612
Establishment and maintenance of pregnancy
require the activity of a highly specialized maternal tissue, the
decidua. It is well established that the human decidua synthesizes and
releases prolactin. However, in the rat, no study has been able to
demonstrate the production of prolactin by the decidua. In this report,
we established for the first time using Northern blot analysis and reverse transcription-polymerase chain reaction, Western blot analysis,
immunocytochemistry, and enzyme-linked immunosorbent assay, that a
defined cell population located in the rat antimesometrial decidua
expresses prolactin mRNA, as well as synthesizes and secretes this
hormone. By reverse transcription-polymerase chain reaction and
rapid amplification of cDNA ends, we cloned a full-length cDNA
for rat decidua prolactin, whose sequence was identical to that of
pituitary prolactin. Our results also showed that pituitary prolactin
appeared to down-regulate decidual prolactin levels. Under these
circumstances, inhibition of pituitary prolactin secretion led to a
rise in both decidual prolactin mRNA and protein expression. Moreover, addition of exogenous prolactin to primary decidual cells in
culture also caused a marked decrease in decidual prolactin mRNA
expression. Finally, treatment of primary decidual cells with steroid
hormones or 8-bromo-cAMP revealed a differential regulation of decidual
prolactin expression from that of pituitary suggesting a
tissue-specific regulation of prolactin gene expression, possibly
through the use of an alternative promoter in rat decidua.
Rat Decidual Prolactin
IDENTIFICATION, MOLECULAR CLONING, AND CHARACTERIZATION*
*
This work was supported by National Institutes of Health
Grant HD-12356 (to G. G.) and a grant from the Ernst Schering
Research Foundation (to C. T.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence and reprints requests should be addressed:
Dept. of Physiology and Biophysics (M/C 901), University of Illinois,
835 S. Wolcott Ave., Chicago, IL 60612-7342. Tel.: 312-996-7688; Fax:
312-996-1414; E-mail: ggibori@uic.edu.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. F Trott, K. C Horigan, J. M Gloviczki, K. M Costa, B. A Freking, C. Farmer, K. Hayashi, T. Spencer, J. E Morabito, and R. C Hovey Tissue-specific regulation of porcine prolactin receptor expression by estrogen, progesterone, and prolactin J. Endocrinol., July 1, 2009; 202(1): 153 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. S. Devi, A. Shehu, C. Stocco, J. Halperin, J. Le, A. M. Seibold, M. Lahav, N. Binart, and G. Gibori Regulation of Transcription Factors and Repression of Sp1 by Prolactin Signaling Through the Short Isoform of Its Cognate Receptor Endocrinology, July 1, 2009; 150(7): 3327 - 3335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. K. Alam, T. Konno, N. Sahgal, L. Lu, and M. J. Soares Decidual Cells Produce a Heparin-binding Prolactin Family Cytokine with Putative Intrauterine Regulatory Actions J. Biol. Chem., July 4, 2008; 283(27): 18957 - 18968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Gonzalez-Fernandez, E. Martinez-Galisteo, F. Gaytan, J. A. Barcena, and J. E. Sanchez-Criado Changes in the Proteome of Functional and Regressing Corpus Luteum During Pregnancy and Lactation in the Rat Biol Reprod, July 1, 2008; 79(1): 100 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ben-Jonathan, C. R. LaPensee, and E. W. LaPensee What Can We Learn from Rodents about Prolactin in Humans? Endocr. Rev., February 1, 2008; 29(1): 1 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Halperin, S. Y. Devi, S. Elizur, C. Stocco, A. Shehu, D. Rebourcet, T. G. Unterman, N. D. Leslie, J. Le, N. Binart, et al. Prolactin Signaling through the Short Form of Its Receptor Represses Forkhead Transcription Factor FOXO3 and Its Target Gene Galt Causing a Severe Ovarian Defect Mol. Endocrinol., February 1, 2008; 22(2): 513 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bao, C. Tessier, A. Prigent-Tessier, F. Li, O. L. Buzzio, E. A. Callegari, N. D. Horseman, and G. Gibori Decidual Prolactin Silences the Expression of Genes Detrimental to Pregnancy Endocrinology, May 1, 2007; 148(5): 2326 - 2334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Eyal, J.-B. Jomain, C. Kessler, V. Goffin, and S. Handwerger Autocrine Prolactin Inhibits Human Uterine Decidualization: A Novel Role for Prolactin Biol Reprod, May 1, 2007; 76(5): 777 - 783. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bachelot and N. Binart Reproductive role of prolactin Reproduction, February 1, 2007; 133(2): 361 - 369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Stocco, C. Telleria, and G. Gibori The Molecular Control of Corpus Luteum Formation, Function, and Regression Endocr. Rev., February 1, 2007; 28(1): 117 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. K. Alam, T. Konno, G. Dai, L. Lu, D. Wang, J. H. Dunmore, A. R. Godwin, and M. J. Soares A uterine decidual cell cytokine ensures pregnancy-dependent adaptations to a physiological stressor Development, January 15, 2007; 134(2): 407 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bao, S. Devi, J. Bowen-Shauver, S. Ferguson-Gottschall, L. Robb, and G. Gibori The Role of Interleukin-11 in Pregnancy Involves Up-Regulation of {alpha}2-Macroglobulin Gene through Janus Kinase 2-Signal Transducer and Activator of Transcription 3 Pathway in the Decidua Mol. Endocrinol., December 1, 2006; 20(12): 3240 - 3250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. K. Yadav, G. Lakshmi, and R. Medhamurthy Prostaglandin F2{alpha}-mediated Activation of Apoptotic Signaling Cascades in the Corpus Luteum during Apoptosis: INVOLVEMENT OF CASPASE-ACTIVATED DNase J. Biol. Chem., March 18, 2005; 280(11): 10357 - 10367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tessier, A. Prigent-Tessier, L. Bao, C. M. Telleria, S. Ferguson-Gottschall, G. B. Gibori, Y. Gu, J. M. Bowen-Shauver, N. D. Horseman, and G. Gibori Decidual Activin: Its Role In the Apoptotic Process and Its Regulation by Prolactin Biol Reprod, May 1, 2003; 68(5): 1687 - 1694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Baran, P. A. Kelly, and N. Binart Decysin, a New Member of the Metalloproteinase Family, Is Regulated by Prolactin and Steroids During Mouse Pregnancy Biol Reprod, May 1, 2003; 68(5): 1787 - 1792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Moons, S. Jirawatnotai, A. F. Parlow, G. Gibori, R. D. Kineman, and H. Kiyokawa Pituitary Hypoplasia and Lactotroph Dysfunction in Mice Deficient for Cyclin-Dependent Kinase-4 Endocrinology, August 1, 2002; 143(8): 3001 - 3008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Thienel, K. Chwalisz, and E. Winterhager Expression of MAPkinases (Erk1/2) during decidualization in the rat: regulation by progesterone and nitric oxide Mol. Hum. Reprod., May 1, 2002; 8(5): 465 - 474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Baran, P. A. Kelly, and N. Binart Characterization of a Prolactin-Regulated Gene in Reproductive Tissues Usingthe Prolactin Receptor Knockout Mouse Model Biol Reprod, April 1, 2002; 66(4): 1210 - 1218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Moons, S. Jirawatnotai, T. Tsutsui, R. Franks, A. F. Parlow, D. B. Hales, G. Gibori, A. T. Fazleabas, and H. Kiyokawa Intact Follicular Maturation and Defective Luteal Function in Mice Deficient for Cyclin- Dependent Kinase-4 Endocrinology, February 1, 2002; 143(2): 647 - 654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tessier, A. Prigent-Tessier, S. Ferguson-Gottschall, Y. Gu, and G. Gibori PRL Antiapoptotic Effect in the Rat Decidua Involves the PI3K/Protein Kinase B-Mediated Inhibition of Caspase-3 Activity Endocrinology, September 1, 2001; 142(9): 4086 - 4094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Prigent-Tessier, U. Barkai, C. Tessier, H. Cohen, and G. Gibori Characterization of a Rat Uterine Cell Line, UIII Cells: Prolactin (PRL) Expression and Endogenous Regulation of PRL-Dependent Genes; Estrogen Receptor {{beta}}, {{alpha}}2-Macroglobulin, and Decidual PRL Involving the Jak2 and Stat5 Pathway Endocrinology, March 1, 2001; 142(3): 1242 - 1250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tessier, S. Deb, A. Prigent-Tessier, S. Ferguson-Gottschall, G. B. Gibori, R. P. C. Shiu, and G. Gibori Estrogen Receptors {alpha} and {beta} in Rat Decidua Cells: Cell-Specific Expression and Differential Regulation by Steroid Hormones and Prolactin Endocrinology, October 1, 2000; 141(10): 3842 - 3851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Barkai, A. Prigent-Tessier, C. Tessier, G. B. Gibori, and G. Gibori Involvement of SOCS-1, the Suppressor of Cytokine Signaling, in the Prevention of Prolactin-Responsive Gene Expression in Decidual Cells Mol. Endocrinol., April 1, 2000; 14(4): 554 - 563. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |