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J Biol Chem, Vol. 274, Issue 6, 3268-3271, February 5, 1999
,,,
From the Macrophage migration inhibitory factor (MIF) is a
relatively small, 12.5-kDa protein that is structurally related to some isomerases and for which multiple immune and catalytic roles have been
proposed. MIF is widely expressed in tissues with particularly high
levels in neural tissues. Here we show that MIF is able to catalyze the
conversion of 3,4-dihydroxyphenylaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitter catecholamines 3,4-dihydroxyphenylamine and norepinephrine, to indoledihydroxy derivatives that may serve as precursors to
neuromelanin. This raises the possibility that MIF participates in a
detoxification pathway for catecholamine products and could therefore
have a protective role in neural tissues, which as in Parkinson's
disease, may be subject to catecholamine-related cell death.
Pigment Cell Biology Section, Department of Biochemistry,
University of Murcia, E-30100 Murcia, Spain
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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