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J Biol Chem, Vol. 274, Issue 6, 3700-3704, February 5, 1999
From the We have characterized a novel partner for
androgen receptor (AR), termed ARIP3, that interacts with the
DNA-binding domain/zinc finger region of AR and is predominantly
expressed in the testis. Rat ARIP3 is a nuclear protein comprising 572 amino acids. It modulates AR-dependent but not basal
transcription, suggesting that ARIP3 acts as an AR transcriptional
coregulator. Except for the C-terminal AR-interacting domain, ARIP3
contains distinct regions that are also present in two recently
described proteins, a protein inhibitor of activated Stat3 and an RNA
helicase II-interacting protein (Gu/RH-II binding protein). Conserved
structural features of these proteins indicate the existence of a gene
family involved in the regulation of various transcription factors.
Collectively, ARIP3 belongs to a novel nuclear protein family and is
perhaps the first tissue-specific coregulator of androgen receptor.
A Testis-specific Androgen Receptor Coregulator That Belongs to a
Novel Family of Nuclear Proteins
,,,¶, and
Department of Physiology,
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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D. Schmidt and S. Muller Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity PNAS, February 20, 2002; (2002) 52559499. [Abstract] [Full Text] [PDF]
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T. Raivio, J. J. Palvimo, L. Dunkel, S. Wickman, and O. A. Jänne Novel Assay for Determination of Androgen Bioactivity in Human Serum J. Clin. Endocrinol. Metab., March 1, 2001; 86(4): 1539 - 1544. [Abstract] [Full Text]
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N. Kotaja, S. Aittomäki, O. Silvennoinen, J. J. Palvimo, and O. A. Jänne ARIP3 (Androgen Receptor-Interacting Protein 3) and Other PIAS (Protein Inhibitor of Activated STAT) Proteins Differ in Their Ability to Modulate Steroid Receptor-Dependent Transcriptional Activation Mol. Endocrinol., December 1, 2000; 14(12): 1986 - 2000. [Abstract] [Full Text]
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J. Liao, Y. Fu, and K. Shuai Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction PNAS, May 9, 2000; 97(10): 5267 - 5272. [Abstract] [Full Text] [PDF]
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 Y. A. Kuryshev, T. I. Gudz, A. M. Brown, and B. A. Wible KChAP as a chaperone for specific K+ channels Am J Physiol Cell Physiol, May 1, 2000; 278(5): C931 - C941. [Abstract] [Full Text] [PDF]
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H Poukka, U Karvonen, N Yoshikawa, H Tanaka, J. Palvimo, and O. Janne The RING finger protein SNURF modulates nuclear trafficking of the androgen receptor J. Cell Sci., January 9, 2000; 113(17): 2991 - 3001. [Abstract] [PDF]
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H. Poukka, P. Aarnisalo, H. Santti, O. A. Janne, and J. J. Palvimo Coregulator Small Nuclear RING Finger Protein (SNURF) Enhances Sp1- and Steroid Receptor-mediated Transcription by Different Mechanisms J. Biol. Chem., January 7, 2000; 275(1): 571 - 579. [Abstract] [Full Text] [PDF]
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J.-a. Tan, S. H. Hall, K. G. Hamil, G. Grossman, P. Petrusz, J. Liao, K. Shuai, and F. S. French Protein Inhibitor of Activated STAT-1 (Signal Transducer and Activator of Transcription-1) Is a Nuclear Receptor Coregulator Expressed in Human Testis Mol. Endocrinol., January 1, 2000; 14(1): 14 - 26. [Abstract] [Full Text]
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A. Negro-Vilar Selective Androgen Receptor Modulators (SARMs): A Novel Approach to Androgen Therapy for the New Millennium J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3459 - 3462. [Full Text] [PDF]
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H. Poukka, P. Aarnisalo, U. Karvonen, J. J. Palvimo, and O. A. Janne Ubc9 Interacts with the Androgen Receptor and Activates Receptor-dependent Transcription J. Biol. Chem., July 2, 1999; 274(27): 19441 - 19446. [Abstract] [Full Text] [PDF]
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P. Aarnisalo, H. Santti, H. Poukka, J. J. Palvimo, and O. A. Jänne Transcription Activating and Repressing Functions of the Androgen Receptor Are Differentially Influenced by Mutations in the Deoxyribonucleic Acid-Binding Domain Endocrinology, July 1, 1999; 140(7): 3097 - 3105. [Abstract] [Full Text]
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N. J. McKenna, R. B. Lanz, and B. W. O’Malley Nuclear Receptor Coregulators: Cellular and Molecular Biology Endocr. Rev., June 1, 1999; 20(3): 321 - 344. [Abstract] [Full Text]
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A. Minty, X. Dumont, M. Kaghad, and D. Caput Covalent Modification of p73alpha by SUMO-1. TWO-HYBRID SCREENING WITH p73 IDENTIFIES NOVEL SUMO-1-INTERACTING PROTEINS AND A SUMO-1 INTERACTION MOTIF J. Biol. Chem., November 10, 2000; 275(46): 36316 - 36323. [Abstract] [Full Text] [PDF]
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M. Sharma, M. Zarnegar, X. Li, B. Lim, and Z. Sun Androgen Receptor Interacts with a Novel MYST Protein, HBO1 J. Biol. Chem., November 3, 2000; 275(45): 35200 - 35208. [Abstract] [Full Text] [PDF]
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B. Liu and K. Shuai Induction of Apoptosis by Protein Inhibitor of Activated Stat1 through c-Jun NH2-terminal Kinase Activation J. Biol. Chem., September 21, 2001; 276(39): 36624 - 36631. [Abstract] [Full Text] [PDF]
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K. Takahashi, T. Taira, T. Niki, C. Seino, S. M. M. Iguchi-Ariga, and H. Ariga DJ-1 Positively Regulates the Androgen Receptor by Impairing the Binding of PIASxalpha to the Receptor J. Biol. Chem., September 28, 2001; 276(40): 37556 - 37563. [Abstract] [Full Text] [PDF]
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D. Schmidt and S. Muller Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity PNAS, March 5, 2002; 99(5): 2872 - 2877. [Abstract] [Full Text] [PDF]
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