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J Biol Chem, Vol. 274, Issue 6, 3910-3917, February 5, 1999
From the Sphingolipid and cholesterol-rich Triton
X-100-insoluble membrane fragments (detergent-resistant membranes,
DRMs) containing lipids in a state similar to the liquid-ordered phase
can be isolated from mammalian cells, and probably exist as discrete
domains or rafts in intact membranes. We postulated that proteins with
a high affinity for such an ordered lipid environment might be targeted to rafts. Saturated acyl chains should prefer an extended conformation that would fit well in rafts. In contrast, prenyl groups, which are as
hydrophobic as acyl chains but have a branched and bulky structure,
should be excluded from rafts. Here, we showed that at least half of
the proteins in Madin-Darby canine kidney cell DRMs (other than
cytoskeletal contaminants) could be labeled with [3H]palmitate. Association of influenza
hemagglutinin with DRMs required all three of its palmitoylated Cys
residues. Prenylated proteins, detected by [3H]mevalonate
labeling or by blotting for Rap1, Rab5, G
Role of Lipid Modifications in Targeting Proteins to
Detergent-resistant Membrane Rafts
MANY RAFT PROTEINS ARE ACYLATED, WHILE FEW ARE PRENYLATED
,,
Department of Biochemistry and Cell Biology,
State University of New York at Stony Brook, Stony Brook, New York
11794-5215 and the ¶ Department of Biochemistry, University of
Texas Southwestern Medical Center, Dallas, Texas 75235-9038
, or Ras, were
excluded from DRMs. Rab5 and H-Ras each contain more than one lipid
group, showing that hydrophobicity alone does not target multiply
lipid-modified proteins to DRMs. Partitioning of covalently linked
saturated acyl chains into liquid-ordered phase domains is likely to be
an important mechanism for targeting proteins to DRMs.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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V. Dolganiuc, L. McGinnes, E. J. Luna, and T. G. Morrison Role of the Cytoplasmic Domain of the Newcastle Disease Virus Fusion Protein in Association with Lipid Rafts J. Virol., December 15, 2003; 77(24): 12968 - 12979. [Abstract] [Full Text] [PDF]
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D. E. Shvartsman, M. Kotler, R. D. Tall, M. G. Roth, and Y. I. Henis Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts J. Cell Biol., November 24, 2003; 163(4): 879 - 888. [Abstract] [Full Text] [PDF]
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S. Kazerounian and S. Aho Characterization of Periphilin, a Widespread, Highly Insoluble Nuclear Protein and Potential Constituent of the Keratinocyte Cornified Envelope J. Biol. Chem., September 19, 2003; 278(38): 36707 - 36717. [Abstract] [Full Text] [PDF]
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A. M. Navratil, S. P. Bliss, K. A. Berghorn, J. M. Haughian, T. A. Farmerie, J. K. Graham, C. M. Clay, and M. S. Roberson Constitutive Localization of the Gonadotropin-releasing Hormone (GnRH) Receptor to Low Density Membrane Microdomains Is Necessary for GnRH Signaling to ERK J. Biol. Chem., August 22, 2003; 278(34): 31593 - 31602. [Abstract] [Full Text] [PDF]
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A. Gidwani, H. A. Brown, D. Holowka, and B. Baird Disruption of lipid order by short-chain ceramides correlates with inhibition of phospholipase D and downstream signaling by Fc{epsilon}RI J. Cell Sci., August 1, 2003; 116(15): 3177 - 3187. [Abstract] [Full Text] [PDF]
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S. Venkatesan, J. J. Rose, R. Lodge, P. M. Murphy, and J. F. Foley Distinct Mechanisms of Agonist-induced Endocytosis for Human Chemokine Receptors CCR5 and CXCR4 Mol. Biol. Cell, August 1, 2003; 14(8): 3305 - 3324. [Abstract] [Full Text] [PDF]
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G. Vereb, J. Szollosi, J. Matko, P. Nagy, T. Farkas, L. Vigh, L. Matyus, T. A. Waldmann, and S. Damjanovich Dynamic, yet structured: The cell membrane three decades after the Singer-Nicolson model PNAS, July 8, 2003; 100(14): 8053 - 8058. [Abstract] [Full Text] [PDF]
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 N. Chazal and D. Gerlier Virus Entry, Assembly, Budding, and Membrane Rafts Microbiol. Mol. Biol. Rev., June 1, 2003; 67(2): 226 - 237. [Abstract] [Full Text] [PDF]
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S. X. Zhang, Y. Han, and G. W. Blissard Palmitoylation of the Autographa californica Multicapsid Nucleopolyhedrovirus Envelope Glycoprotein GP64: Mapping, Functional Studies, and Lipid Rafts J. Virol., June 1, 2003; 77(11): 6265 - 6273. [Abstract] [Full Text] [PDF]
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R. M. Young, D. Holowka, and B. Baird A Lipid Raft Environment Enhances Lyn Kinase Activity by Protecting the Active Site Tyrosine from Dephosphorylation J. Biol. Chem., May 30, 2003; 278(23): 20746 - 20752. [Abstract] [Full Text] [PDF]
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T. L. Baker, H. Zheng, J. Walker, J. L. Coloff, and J. E. Buss Distinct Rates of Palmitate Turnover on Membrane-bound Cellular and Oncogenic H-Ras J. Biol. Chem., May 23, 2003; 278(21): 19292 - 19300. [Abstract] [Full Text] [PDF]
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A. Hiol, P. C. Davey, J. L. Osterhout, A. A. Waheed, E. R. Fischer, C.-K. Chen, G. Milligan, K. M. Druey, and T. L. Z. Jones Palmitoylation Regulates Regulators of G-protein Signaling (RGS) 16 Function: I. MUTATION OF AMINO-TERMINAL CYSTEINE RESIDUES ON RGS16 PREVENTS ITS TARGETING TO LIPID RAFTS AND PALMITOYLATION OF AN INTERNAL CYSTEINE RESIDUE J. Biol. Chem., May 23, 2003; 278(21): 19301 - 19308. [Abstract] [Full Text] [PDF]
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 J. K. Zehmer and J. R. Hazel Plasma membrane rafts of rainbow trout are subject to thermal acclimation J. Exp. Biol., May 15, 2003; 206(10): 1657 - 1667. [Abstract] [Full Text] [PDF]
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 J. A. G. Briggs, T. Wilk, and S. D. Fuller Do lipid rafts mediate virus assembly and pseudotyping? J. Gen. Virol., April 1, 2003; 84(4): 757 - 768. [Abstract] [Full Text] [PDF]
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V. D. Dixit, R. Sridaran, M. A. Edmonsond, D. Taub, and W. E. Thompson Gonadotropin-Releasing Hormone Attenuates Pregnancy-Associated Thymic Involution and Modulates the Expression of Antiproliferative Gene Product Prohibitin Endocrinology, April 1, 2003; 144(4): 1496 - 1505. [Abstract] [Full Text] [PDF]
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K. Ishikawa, N. L. Catlett, J. L. Novak, F. Tang, J. J. Nau, and L. S. Weisman Identification of an organelle-specific myosin V receptor J. Cell Biol., March 17, 2003; 160(6): 887 - 897. [Abstract] [Full Text] [PDF]
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L. M. Pierini, R. J. Eddy, M. Fuortes, S. Seveau, C. Casulo, and F. R. Maxfield Membrane Lipid Organization Is Critical for Human Neutrophil Polarization J. Biol. Chem., March 14, 2003; 278(12): 10831 - 10841. [Abstract] [Full Text] [PDF]
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E. V. Kalinina and L. D. Fricker Palmitoylation of Carboxypeptidase D. IMPLICATIONS FOR INTRACELLULAR TRAFFICKING J. Biol. Chem., March 7, 2003; 278(11): 9244 - 9249. [Abstract] [Full Text] [PDF]
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N. Gupta and A. L. DeFranco Visualizing Lipid Raft Dynamics and Early Signaling Events during Antigen Receptor-mediated B-Lymphocyte Activation Mol. Biol. Cell, February 1, 2003; 14(2): 432 - 444. [Abstract] [Full Text] [PDF]
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Y. Percherancier, B. Lagane, T. Planchenault, I. Staropoli, R. Altmeyer, J.-L. Virelizier, F. Arenzana-Seisdedos, D. C. Hoessli, and F. Bachelerie HIV-1 Entry into T-cells Is Not Dependent on CD4 and CCR5 Localization to Sphingolipid-enriched, Detergent-resistant, Raft Membrane Domains J. Biol. Chem., January 24, 2003; 278(5): 3153 - 3161. [Abstract] [Full Text] [PDF]
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 I. Semac, C. Palomba, K. Kulangara, N. Klages, G. van Echten-Deckert, B. Borisch, and D. C. Hoessli Anti-CD20 Therapeutic Antibody Rituximab Modifies the Functional Organization of Rafts/Microdomains of B Lymphoma Cells Cancer Res., January 15, 2003; 63(2): 534 - 540. [Abstract] [Full Text] [PDF]
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I. C. Morrow, S. Rea, S. Martin, I. A. Prior, R. Prohaska, J. F. Hancock, D. E. James, and R. G. Parton Flotillin-1/Reggie-2 Traffics to Surface Raft Domains via a Novel Golgi-independent Pathway. IDENTIFICATION OF A NOVEL MEMBRANE TARGETING DOMAIN AND A ROLE FOR PALMITOYLATION J. Biol. Chem., December 6, 2002; 277(50): 48834 - 48841. [Abstract] [Full Text] [PDF]
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B. Barylko, P. Wlodarski, D. D. Binns, S. H. Gerber, S. Earnest, T. C. Sudhof, N. Grichine, and J. P. Albanesi Analysis of the Catalytic Domain of Phosphatidylinositol 4-Kinase Type II J. Biol. Chem., November 8, 2002; 277(46): 44366 - 44375. [Abstract] [Full Text] [PDF]
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T. Nebl, K. N. Pestonjamasp, J. D. Leszyk, J. L. Crowley, S. W. Oh, and E. J. Luna Proteomic Analysis of a Detergent-resistant Membrane Skeleton from Neutrophil Plasma Membranes J. Biol. Chem., November 1, 2002; 277(45): 43399 - 43409. [Abstract] [Full Text] [PDF]
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M. Li, C. Yang, S. Tong, A. Weidmann, and R. W. Compans Palmitoylation of the Murine Leukemia Virus Envelope Protein Is Critical for Lipid Raft Association and Surface Expression J. Virol., October 25, 2002; 76(23): 11845 - 11852. [Abstract] [Full Text] [PDF]
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 C. N. Shrimpton, G. Borthakur, S. Larrucea, M. A. Cruz, J.-F. Dong, and J. A. Lopez Localization of the Adhesion Receptor Glycoprotein Ib-IX-V Complex to Lipid Rafts Is Required for Platelet Adhesion and Activation J. Exp. Med., October 21, 2002; 196(8): 1057 - 1066. [Abstract] [Full Text] [PDF]
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