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J Biol Chem, Vol. 274, Issue 7, 4202-4206, February 12, 1999

Why Superoxide Imposes an Aromatic Amino Acid Auxotrophy on Escherichia coli
THE TRANSKETOLASE CONNECTION

From the Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710

The lack of superoxide dismutase and the consequent elevation of [O₂] imposes, on Escherichia coli, auxotrophies for branched chain, sulfur-containing, and aromatic amino acids. The former two classes of auxotrophies have already been explained, whereas the third is explained herein. Thus O₂ is shown to interfere with the production of erythrose-4-phosphate, which is essential for the first step of the aromatic biosynthetic pathway. It does so by oxidizing the 1,2-dihydroxyethyl thiamine pyrophosphate intermediate of transketolase and inactivating this enzyme.

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