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J Biol Chem, Vol. 274, Issue 7, 4202-4206, February 12, 1999
From the Department of Biochemistry, Duke University Medical
Center, Durham, North Carolina 27710
The lack of superoxide dismutase and the
consequent elevation of [O2
] imposes, on
Escherichia coli, auxotrophies for branched chain, sulfur-containing, and aromatic amino acids. The former two classes of
auxotrophies have already been explained, whereas the third is
explained herein. Thus O2 is shown to interfere with
the production of erythrose-4-phosphate, which is essential for the
first step of the aromatic biosynthetic pathway. It does so by
oxidizing the 1,2-dihydroxyethyl thiamine pyrophosphate intermediate of
transketolase and inactivating this enzyme.
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