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J Biol Chem, Vol. 274, Issue 7, 4231-4238, February 12, 1999
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From the Transgenic tobacco plants with reduced activity
of either uroporphyrinogen decarboxylase or coproporphyrinogen oxidase,
two enzymes of the tetrapyrrole biosynthetic pathway, are characterized by the accumulation of photosensitizing tetrapyrrole intermediates, antioxidative responses, and necrotic leaf lesions. In this study we
report on cellular responses in uroporphyrinogen decarboxylase and
coproporphyrinogen oxidase antisense plants, normally associated with
pathogen defense. These plants accumulate the highly fluorescent coumarin scopolin in their leaves. They also display increased pathogenesis-related protein expression and higher levels of free and
conjugated salicylic acid. Upon tobacco mosaic virus inoculation, the
plants with leaf lesions and high levels of PR-1 mRNA
expression show reduced accumulation of virus RNA relative to wild-type
controls. This result is indicative of an increased resistance to
tobacco mosaic virus. We conclude that porphyrinogenesis as a result of deregulated tetrapyrrole synthesis induces a set of defense responses that resemble the hypersensitive reaction observed after pathogen attack.
Institut für Pflanzengenetik und
Kulturpflanzenforschung, Biotechnology and Genomics
Center, Novartis Crop Protection, Inc., Research Triangle Park,
North Carolina 27709-2257
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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