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J Biol Chem, Vol. 274, Issue 7, 4254-4258, February 12, 1999

Identification and Functional Expression of the Plasma Membrane Calcium ATPase Gene Family from Caenorhabditis elegans

From the Institute of Biochemistry, Swiss Federal Institute of Technology (ETH), 8092 Zürich, Switzerland and the Department of Biological Chemistry, University of Padova, 35121 Padova, Ialy

Calcium-pumping ATPases are an essential component of the intracellular calcium homeostasis system and have been characterized in a large variety of species and cell types. In mammalian genomes, these proteins are encoded by gene families whose individual members feature complex tissue-specific expression and alternative splicing. In the search for a less complex system that is more amenable to genetic manipulation, we have identified a family of three genes (mca-1, mca-2, and mca-3) encoding putative calcium ATPases in the Caenorhabditis elegans Genome Project data and completed their transcript structure. In this work, we report the cloning and functional expression of the mca-1 gene, which encodes a calcium-stimulated ATPase whose features resemble those of the plasma membrane calcium adenosine triphosphatase family of mammalian cells and appears to be regulated by a multipartite promoter.

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