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J Biol Chem, Vol. 274, Issue 9, 5385-5390, February 26, 1999
-Adaptin
From the Zentrum für Biochemie und Molekulare Zellbiologie,
Dept. Biochemie II, Universität Göttingen,
Gosslerstrasse 12D, 37073 Göttingen, Germany
Intracellular protein transport and sorting by
vesicles in the secretory and endocytic pathways requires the formation
of a protein coat on the membrane. The heterotetrameric adaptor protein complex 1 (AP-1) promotes the formation of clathrin-coated vesicles at
the trans-Golgi network. AP-1 interacts with various
sorting signals in the cytoplasmic tails of cargo molecules, thus
indicating a function in protein sorting. We generated mutants of the
-adaptin subunit of AP-1 in mice to investigate its role in
post-Golgi vesicle transport and sorting processes.
-Adaptin-deficient embryos develop until day 3.5 post coitus and die
during the prenidation period, revealing that AP-1 is essential for
viability. In heterozygous mice the amount of AP-1 complexes is reduced
to half of controls. Free 
1- or µ1 chains were not detectable,
indicating that they are unstable unless they are part of AP-1
complexes. Heterozygous mice weigh less then their wild-type
littermates and show impaired T cell development.
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