| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 9, 5422-5428, February 26, 1999
From the Molecular Biology and Virology Laboratory, The Salk
Institute for Biological Studies, La Jolla, California 92037
Increased expression of the insulin-like growth
factor-I receptor (IGF-IR) protein-tyrosine kinase occurs in several
kinds of cancer and induces neoplastic transformation in fibroblast cell lines. The transformed phenotype can be reversed by interfering with the function of the IGF-IR. The IGF-IR is required for
transformation by a number of viral and cellular oncoproteins,
including SV40 large T antigen, Ras, Raf, and Src. The IGF-IR is a
substrate for Src in vitro and is phosphorylated in
v-Src-transformed cells. We observed that the IGF-IR and IR associated
with the C-terminal Src kinase (CSK) following ligand stimulation. We
found that the SH2 domain of CSK binds to the tyrosine-phosphorylated
form of IGF-IR and IR. We determined the tyrosine residues in the
IGF-IR and in the IR responsible for this interaction. We also observed that fibroblasts stimulated with IGF-I or insulin showed a rapid and
transient decrease in c-Src tyrosine kinase activity. The results
suggest that c-Src and CSK are involved in IGF-IR and IR signaling and
that the interaction of CSK with the IGF-IR may play a role in the
decrease in c-Src activity following IGF-I stimulation.
This article has been cited by other articles:
|
|
 |
|
  S. Bunda, P. Liu, Y. Wang, K. Liu, and A. Hinek Aldosterone Induces Elastin Production in Cardiac Fibroblasts through Activation of Insulin-Like Growth Factor-I Receptors in a Mineralocorticoid Receptor-Independent Manner Am. J. Pathol., September 1, 2007; 171(3): 809 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Ayrapetov, N. H. Nam, G. Ye, A. Kumar, K. Parang, and G. Sun Functional Diversity of Csk, Chk, and Src SH2 Domains due to a Single Residue Variation J. Biol. Chem., July 8, 2005; 280(27): 25780 - 25787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Biedi, D. Panetta, D. Segat, R. Cordera, and D. Maggi Specificity of Insulin-Like Growth Factor I and Insulin on Shc Phosphorylation and Grb2 Recruitment in Caveolae Endocrinology, December 1, 2003; 144(12): 5497 - 5503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Brdickova, T. Brdicka, P. Angelisova, O. Horvath, J. Spicka, I. Hilgert, J. Paces, L. Simeoni, S. Kliche, C. Merten, et al. LIME: A New Membrane Raft-associated Adaptor Protein Involved in CD4 and CD8 Coreceptor Signaling J. Exp. Med., November 17, 2003; 198(10): 1453 - 1462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sekimoto and C. M. Boney C-Terminal Src Kinase (CSK) Modulates Insulin-Like Growth Factor-I Signaling through Src in 3T3-L1 Differentiation Endocrinology, June 1, 2003; 144(6): 2546 - 2552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Kiely, A. Sant, and R. O'Connor RACK1 Is an Insulin-like Growth Factor 1 (IGF-1) Receptor-interacting Protein That Can Regulate IGF-1-mediated Akt Activation and Protection from Cell Death J. Biol. Chem., June 14, 2002; 277(25): 22581 - 22589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Luis Del Valle, S. Enam, A. Lassak, J. Y. Wang, S. Croul, K. Khalili, and K. Reiss Insulin-like Growth Factor I Receptor Activity in Human Medulloblastomas Clin. Cancer Res., June 1, 2002; 8(6): 1822 - 1830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Hermanto, C. S. Zong, W. Li, and L.-H. Wang RACK1, an Insulin-Like Growth Factor I (IGF-I) Receptor-Interacting Protein, Modulates IGF-I-Dependent Integrin Signaling and Promotes Cell Spreading and Contact with Extracellular Matrix Mol. Cell. Biol., April 1, 2002; 22(7): 2345 - 2365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Boney, H. Sekimoto, P. A. Gruppuso, and A. R. Frackelton Jr. Src Family Tyrosine Kinases Participate in Insulin-like Growth Factor I Mitogenic Signaling in 3T3-L1 Cells Cell Growth Differ., July 1, 2001; 12(7): 379 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Playford, D. Bicknell, W. F. Bodmer, and V. M. Macaulay Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta -catenin PNAS, October 12, 2000; (2000) 210394297. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. M. Boney, P. A. Gruppuso, R. A. Faris, and A. R. Frackelton Jr. The Critical Role of Shc in Insulin-Like Growth Factor-I-Mediated Mitogenesis and Differentiation in 3T3-L1 Preadipocytes Mol. Endocrinol., June 1, 2000; 14(6): 805 - 813. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. M. Moasser, M. Srethapakdi, K. S. Sachar, A. J. Kraker, and N. Rosen Inhibition of Src Kinases by a Selective Tyrosine Kinase Inhibitor Causes Mitotic Arrest Cancer Res., December 1, 1999; 59(24): 6145 - 6152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Torgersen, T. Vang, H. Abrahamsen, S. Yaqub, V. Horejsi, B. Schraven, B. Rolstad, T. Mustelin, and K. Tasken Release from Tonic Inhibition of T Cell Activation through Transient Displacement of C-terminal Src Kinase (Csk) from Lipid Rafts J. Biol. Chem., July 27, 2001; 276(31): 29313 - 29318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Playford, D. Bicknell, W. F. Bodmer, and V. M. Macaulay Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta -catenin PNAS, October 24, 2000; 97(22): 12103 - 12108. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
