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J Biol Chem, Vol. 274, Issue 9, 5888-5894, February 26, 1999
From the Institute for Chemical Reaction Science, Tohoku
University, 2-1-1 Katahira, Aoba-ku, Sendai, 980-8577, Japan
Geranylgeranyl diphosphate (GGPP) synthase
(GGPPSase) catalyzes the synthesis of GGPP, which is an important
molecule responsible for the C20-prenylated protein
biosynthesis and for the regulation of a nuclear hormone receptor
(LXR·RXR). The human GGPPSase cDNA encodes a protein of 300 amino
acids which shows 16% sequence identity with the known human farnesyl
diphosphate (FPP) synthase (FPPSase). The GGPPSase expressed in
Escherichia coli catalyzes the GGPP formation (240 nmol/min/mg) from FPP and isopentenyl diphosphate. The human GGPPSase
behaves as an oligomeric molecule with 280 kDa on a gel filtration
column and cross-reacts with an antibody directed against bovine brain
GGPPSase, which differs immunochemically from bovine brain FPPSase.
Northern blot analysis indicates the presence of two forms of the mRNA.
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