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J Biol Chem, Vol. 275, Issue 1, 147-153, January 7, 2000
From Unité INSERM U453, Centre Léon Bérard, 69373 Lyon Cedex 08, France
BTG1 and BTG2 belong to a
family of functionally related genes involved in the control of the
cell cycle. As part of an ongoing attempt to understand their
biological functions, we used a yeast two-hybrid screening to look for
possible functional partners of Btg1 and Btg2. Here we report the
physical and functional association between these proteins and the
homeodomain protein Hoxb9. We further show that Btg1 and Btg2 enhance
Hoxb9-mediated transcription in transfected cells, and we report the
formation of a Hoxb9·Btg2 complex on a Hoxb9-responsive target, and
the fact that this interaction facilitates the binding of Hoxb9 to DNA.
The transcriptional activity of the Hoxb9·Btg complex is
essentially dependent on the activation domain of Hoxb9, located
in the N-terminal portion of the protein. Our data indicate that Btg1
and Btg2 act as transcriptional cofactors of the Hoxb9 protein,
and suggest that this interaction may mediate their
antiproliferative function.
The Leukemia-associated Protein Btg1 and the p53-regulated
Protein Btg2 Interact with the Homeoprotein Hoxb9 and Enhance Its
Transcriptional Activation*
,
*
This work was supported in part by the Groupement des
Entreprises Françaises dans la Lutte contre le Cancer; by the
Ligue Nationale Contre le Cancer, Comité de l'Ardèche; and
by Association pour la Recherche sur le Cancer Grant 9718.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Recipient of a Ministère de l'Education National de la
Recherche et de la Technologie fellowship.
§
To whom correspondence should be addressed: Unité INSERM
U453, Centre Léon Bérard, 28 rue Laënnec, 69373 Lyon
Cedex 08, France. Tel.: 33-4-78-78-26-91; Fax: 33-4-78-78-27-20;
E-mail: corbo@lyon.fnclcc.fr.
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