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J Biol Chem, Vol. 275, Issue 10, 7045-7051, March 10, 2000
From the Department of Biological Sciences, Korea Advanced
Institute of Science and Technology, Taejon 305-701, Korea
cAMP response element-binding protein-binding
protein (CBP) is a eucaryotic transcriptional co-activator that
contains multiple protein-protein interaction domains for association
with various transcription factors, components of the basal
transcriptional apparatus, and other co-activator proteins. Here, we
report that CBP is also a co-activator of the human papillomavirus
(HPV) E2 protein, which is a sequence-specific
transcription/replication factor. We provide biochemical, genetic, and
functional evidence that CBP binds directly to HPV E2 in
vivo and in vitro and activates E2-dependent transcription. Mutations in an amphipathic
helix within HPV-18 E2 abolish its transcriptional activation
properties and its ability to bind to CBP. Furthermore, the binding of
CBP to E2 was shown to be necessary for E2-dependent
transcription. Interestingly, the histone acetyltransferase activity of
CBP plays a role in CBP activation of E2-dependent transcription.
cAMP Response Element-binding Protein-binding Protein Binds to
Human Papillomavirus E2 Protein and Activates E2-dependent
Transcription*
*
This work was supported by the Academic Research Fund of the
Ministry of Education, Republic of Korea, and by the Molecular Medicine
Research Group Program of the Korea Institute of Science & Technology
Evaluation and Planning through the Biomedical Research Center at the
Korea Advanced Institute of Science and Technology.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed. Tel.: 82-42-869-2630;
Fax: 82-42-869-5630; E-mail: jchoe@mail.kaist.ac.kr.
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