| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 275, Issue 11, 8032-8037, March 17, 2000
From Immunex Corporation, Seattle, Washington 98101
Crystals seldom form spontaneously within tissues
of mammals, except in the urinary tract or in association with
eosinophil-rich diseases in humans (Charcot-Leyden crystals).
Endogenously formed eosinophilic crystals have been reported in
respiratory tract and other tissues of several strains of mice, but the
biochemical characterization of these crystals has not been reported.
In this study, eosinophilic crystal formation was examined in
homozygous C57BL/6J viable motheaten mice, lung-specific surfactant
apoprotein C promoter/soluble human tumor necrosis factor p75 receptor
type II fusion protein transgenic mice (C57BL/6NTac × Sv/129),
and CD40L-deficient mice with spontaneous Pneumocystis
carinii infection. In viable motheaten but not wild type mice,
rapidly developing crystals represented a major feature of the fatal
lung injury induced by macrophage dysregulation. Conversely,
eosinophilic crystals did not form until 4-8 months of age in
transgenic and CD40L-deficient mice and were present in 10-30% of
age-matched wild type controls. Mass spectrometry analysis of proteins
from bronchoalveolar lavage fluid identified the crystals as Ym1,
sometimes referred to as T-lymphocyte-derived eosinophil chemotactic
factor. The Ym1 sequence was homologous to chitinase, and enzymatic
assays indicated a 3-5-fold increase in chitinase activity compared
with control mice. Intracellular and extracellular crystals associated with epithelial damage suggested that the crystals may contribute to
lung inflammation through mechanical damage and enzymatic degradation.
Biochemical Characterization of Endogenously Formed Eosinophilic
Crystals in the Lungs of Mice*
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom all correspondence should be addressed: Immunex Corp., 51 University St., Seattle, WA 98101. Tel.: 206-389-4361; Fax: 206-233-9733; E-mail: schuhj@immunex.com.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Baldan, A. V. Gomes, P. Ping, and P. A. Edwards Loss of ABCG1 Results in Chronic Pulmonary Inflammation J. Immunol., March 1, 2008; 180(5): 3560 - 3568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Hoenerhoff, M. F. Starost, and J. M. Ward Eosinophilic Crystalline Pneumonia as a Major Cause of Death in 129S4/SvJae Mice. Vet. Pathol., September 1, 2006; 43(5): 682 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Marchesi, S. Minucci, P. G. Pelicci, A. Gobbi, and E. Scanziani Immunohistochemical Detection of Ym1/Ym2 Chitinase-like Lectins Associated with Hyalinosis and Polypoid Adenomas of the Transitional Epithelium in a Mouse with Acute Myeloid Leukemia. Vet. Pathol., September 1, 2006; 43(5): 773 - 776. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yang, J. Gao, M. Adamian, X.-H. Wen, B. Pawlyk, L. Zhang, M. J. Sanderson, J. Zuo, C. L. Makino, and T. Li The Ciliary Rootlet Maintains Long-Term Stability of Sensory Cilia Mol. Cell. Biol., May 15, 2005; 25(10): 4129 - 4137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Arora, Y. Hernandez, J. R. Erb-Downward, R. A. McDonald, G. B. Toews, and G. B. Huffnagle Role of IFN-{gamma} in Regulating T2 Immunity and the Development of Alternatively Activated Macrophages during Allergic Bronchopulmonary Mycosis J. Immunol., May 15, 2005; 174(10): 6346 - 6356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Nair, I. J. Gallagher, M. D. Taylor, P. Loke, P. S. Coulson, R. A. Wilson, R. M. Maizels, and J. E. Allen Chitinase and Fizz Family Members Are a Generalized Feature of Nematode Infection with Selective Upregulation of Ym1 and Fizz1 by Antigen-Presenting Cells Infect. Immun., January 1, 2005; 73(1): 385 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Hickman-Davis, J. Gibbs-Erwin, J. R. Lindsey, and S. Matalon Role of Surfactant Protein-A in Nitric Oxide Production and Mycoplasma Killing in Congenic C57BL/6 Mice Am. J. Respir. Cell Mol. Biol., March 1, 2004; 30(3): 319 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Welch, L. Escoubet-Lozach, D. B. Sykes, K. Liddiard, D. R. Greaves, and C. K. Glass TH2 Cytokines and Allergic Challenge Induce Ym1 Expression in Macrophages by a STAT6-dependent Mechanism J. Biol. Chem., November 1, 2002; 277(45): 42821 - 42829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ernst, M. Inglese, G. M. Scholz, K. W. Harder, F. J. Clay, S. Bozinovski, P. Waring, R. Darwiche, T. Kay, P. Sly, et al. Constitutive Activation of the Src Family Kinase Hck Results in Spontaneous Pulmonary Inflammation and an Enhanced Innate Immune Response J. Exp. Med., September 2, 2002; 196(5): 589 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-I. Hung, A. C. Chang, I. Kato, and N.-C. A. Chang Transient expression of Ym1, a heparin-binding lectin, during developmental hematopoiesis and inflammation J. Leukoc. Biol., July 1, 2002; 72(1): 72 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Homer, T. Zheng, G. Chupp, S. He, Z. Zhu, Q. Chen, B. Ma, R. D. Hite, L. I. Gobran, S. A. Rooney, et al. Pulmonary type II cell hypertrophy and pulmonary lipoproteinosis are features of chronic IL-13 exposure Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L52 - L59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Raes, P. De Baetselier, W. Noel, A. Beschin, F. Brombacher, and G. Hassanzadeh Gh. Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages J. Leukoc. Biol., April 1, 2002; 71(4): 597 - 602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Harbord, M. Novelli, B. Canas, D. Power, C. Davis, J. Godovac-Zimmermann, J. Roes, and A. W. Segal Ym1 Is a Neutrophil Granule Protein That Crystallizes in p47phox-deficient Mice J. Biol. Chem., February 8, 2002; 277(7): 5468 - 5475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Webb, A. N. J. McKenzie, and P. S. Foster Expression of the Ym2 Lectin-binding Protein Is Dependent on Interleukin (IL)-4 and IL-13 Signal Transduction. IDENTIFICATION OF A NOVEL ALLERGY-ASSOCIATED PROTEIN J. Biol. Chem., November 2, 2001; 276(45): 41969 - 41976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. H. Falcone, P'n. Loke, X. Zang, A. S. MacDonald, R. M. Maizels, and J. E. Allen A Brugia malayi Homolog of Macrophage Migration Inhibitory Factor Reveals an Important Link Between Macrophages and Eosinophil Recruitment During Nematode Infection J. Immunol., November 1, 2001; 167(9): 5348 - 5354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pande, J. Pande, N. Asherie, A. Lomakin, O. Ogun, J. King, and G. B. Benedek Crystal cataracts: Human genetic cataract caused by protein crystallization PNAS, May 22, 2001; 98(11): 6116 - 6120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Feldmesser, Y. Kress, and A. Casadevall Intracellular Crystal Formation as a Mechanism of Cytotoxicity in Murine Pulmonary Cryptococcus neoformans Infection Infect. Immun., April 1, 2001; 69(4): 2723 - 2727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Mizgerd, M. R. Spieker, and C. M. Doerschuk Early Response Cytokines and Innate Immunity: Essential Roles for TNF Receptor 1 and Type I IL-1 Receptor During Escherichia coli Pneumonia in Mice J. Immunol., March 15, 2001; 166(6): 4042 - 4048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Fallon, C. L. Emson, P. Smith, and A. N. J. McKenzie IL-13 Overexpression Predisposes to Anaphylaxis Following Antigen Sensitization J. Immunol., February 15, 2001; 166(4): 2712 - 2716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Ward, M. Yoon, M. R. Anver, D. C. Haines, G. Kudo, F. J. Gonzalez, and S. Kimura Hyalinosis and Ym1/Ym2 Gene Expression in the Stomach and Respiratory Tract of 129S4/SvJae and Wild-Type and CYP1A2-Null B6,129 Mice Am. J. Pathol., January 1, 2001; 158(1): 323 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Olszewski, G. B. Huffnagle, R. A. McDonald, D. M. Lindell, B. B. Moore, D. N. Cook, and G. B. Toews The Role of Macrophage Inflammatory Protein-1{alpha}/CCL3 in Regulation of T Cell-Mediated Immunity to Cryptococcus neoformans Infection J. Immunol., December 1, 2000; 165(11): 6429 - 6436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N.-C. A. Chang, S.-I. Hung, K.-Y. Hwa, I. Kato, J.-E. Chen, C.-H. Liu, and A. C. Chang A Macrophage Protein, Ym1, Transiently Expressed during Inflammation Is a Novel Mammalian Lectin J. Biol. Chem., May 11, 2001; 276(20): 17497 - 17506. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
