Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Renz, M.
Right arrow Articles by Stewart, T. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Renz, M.
Right arrow Articles by Stewart, T. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

J Biol Chem, Vol. 275, Issue 14, 10429-10436, April 7, 2000

Quantitative Expression Analysis of Genes Regulated by Both Obesity and Leptin Reveals a Regulatory Loop between Leptin and Pituitary-derived ACTH*

Mark RenzDagger , Elizabeth TomlinsonDagger , Bruce HultgrenDagger , Nancy LevinDagger §, Qimin GuDagger , Richard A. Shimkets, David A. Lewin, and Timothy A. StewartDagger ||

From the Dagger  Department of Endocrine Research, Genentech, Inc., South San Francisco, California 94080 and  Gene Discovery, CuraGen Corp., New Haven, Connecticut 06511

Absence of the hormone leptin leads to dramatic increases in appetite, food intake, and adiposity. The primary site of action, at least with respect to appetite, is the hypothalamus. Leptin also has significant effects on the function(s) of peripheral organs involved in maintaining body composition. Some of these effects are mediated through direct interaction of leptin with its receptor on the target tissue, and some effects are indirectly mediated through secondary hormonal and neural pathways. Few of the genes that are responsible for regulating body composition and the peripheral effects of leptin are known. We have used a new gene profiling technology to characterize gene expression changes that occur in the pituitary, hypothalamus, fat, muscle, and liver in response to both obesity and treatment with exogenous leptin. These differences were then overlaid to allow the identification of genes that are regulated by obesity and at least partially normalized by leptin treatment. By using this process we have identified five genes (POMC, PC2, prolactin, HSGP25L2G, and one novel) that are both abnormally expressed in the pituitaries of obese mice and are sensitive to the effects of leptin. We also show that adrenocorticotropic hormone appears to be involved in a regulatory loop involving leptin.

* The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

§ Present address: Amgen Inc., Thousand Oaks, CA.

|| To whom correspondence should be addressed: Dept. of Endocrine Research, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080. Tel.: 650-225-1222; Fax: 650-225-6497; E-mail: tas@gene.com.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Guo, H. Munzberg, R. C. Stuart, E. A. Nillni, and C. Bjorbaek
N-acetylation of hypothalamic {alpha}-melanocyte-stimulating hormone and regulation by leptin
PNAS, August 10, 2004; 101(32): 11797 - 11802.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. Watanobe
Leptin directly acts within the hypothalamus to stimulate gonadotropin-releasing hormone secretion in vivo in rats
J. Physiol., November 15, 2002; 545(1): 255 - 268.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Klein, A. R. de Fougerolles, P. Blaikie, L. Khan, A. Pepe, C. D. Green, V. Koteliansky, and F. G. Giancotti
{alpha}5{beta}1 Integrin Activates an NF-{kappa}B-Dependent Program of Gene Expression Important for Angiogenesis and Inflammation
Mol. Cell. Biol., August 15, 2002; 22(16): 5912 - 5922.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. S. Jessop, M. F. Dallman, D. Fleming, and S. L. Lightman
Resistance to Glucocorticoid Feedback in Obesity
J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4109 - 4114.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Tartare-Deckert, C. Chavey, M.-N. Monthouel, N. Gautier, and E. Van Obberghen
The Matricellular Protein SPARC/Osteonectin as a Newly Identified Factor Up-regulated in Obesity
J. Biol. Chem., June 15, 2001; 276(25): 22231 - 22237.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C.-P. Liang and A. R. Tall
Transcriptional Profiling Reveals Global Defects in Energy Metabolism, Lipoprotein, and Bile Acid Synthesis and Transport with Reversal by Leptin Treatment in Ob/ob Mouse Liver
J. Biol. Chem., December 21, 2001; 276(52): 49066 - 49076.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2000 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement