| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 275, Issue 16, 12102-12107, April 21, 2000
From The Burnham Institute, La Jolla, California 92037 and the
§ Center for Molecular Genetics, University of California
San Diego, La Jolla, California 92093
A member of the tumor necrosis factor (TNF)
receptor-associated factor (TRAF) family was identified in
Drosophila. DTRAF1 contains 7 zinc finger domains followed
by a TRAF domain, similar to mammalian TRAFs and other members of the
family identified in data bases from Caenorhabditis
elegans, Arabidopsis, and Dictyostelium. Analysis of DTRAF1 binding to different members of the human TNF receptor family showed that this protein can interact through its TRAF
domain with the p75 neurotrophin receptor and weakly with the
lymphotoxin-
The Drosophila Tumor Necrosis Factor
Receptor-associated Factor-1 (DTRAF1) Interacts with Pelle and
Regulates NF
B Activity*
,
receptor. DTRAF1 can also self-associate and binds to
human TRAF1, TRAF2, and TRAF4. Interestingly, DTRAF1 interacts with
human cIAP-1 and cIAP-2 but not with Drosophila DIAP-1 and
-2. By itself, DTRAF1 did not induce significant NF
B activation when
overexpressed in mammalian cells, although it specifically increased
NFB induction by TRAF6. In contrast, TRAF2-mediated NFB induction
was partially inhibited by DTRAF1. Mutants of DTRAF1 lacking the
N-terminal region inhibited NFB induction by either TRAF2 or TRAF6.
DTRAF1 specifically associated with the regulatory N-terminal domain of
Pelle, a Drosophila homolog of the human kinase
interleukin-1 receptor-associated kinase (IRAK). Interestingly, though
Pelle and DTRAF1 individually were unable to induce NFB in a human
cell line, co-expression of Pelle and DTRAF1 resulted in significant
NFB activity. Interactions of DTRAF1 with human TRAF-, TNF
receptor-, and IAP-family proteins imply strong evolutionary conservation of TRAF protein structure and function throughout Metazoan evolution.
*
This work was supported in part by National Institutes of
Health Grants CA-69381 and GM50545 and also by Zaiya Inc.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
A research fellow of the Lymphoma Research Foundation of America.
¶
To whom correspondence should be addressed: The Burnham
Institute, 10901 N. Torrey Pines Rd., La Jolla, CA 92037. Tel.:
858-646-3140; Fax: 858-646-3194; E-mail: jreed@burnham-inst.org.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  G.-H. Cha, K. S. Cho, J. H. Lee, M. Kim, E. Kim, J. Park, S. B. Lee, and J. Chung Discrete Functions of TRAF1 and TRAF2 in Drosophila melanogaster Mediated by c-Jun N-Terminal Kinase and NF-{kappa}B-Dependent Signaling Pathways Mol. Cell. Biol., November 15, 2003; 23(22): 7982 - 7991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Sun, B. N. Bristow, G. Qu, and S. A. Wasserman A heterotrimeric death domain complex in Toll signaling PNAS, October 1, 2002; 99(20): 12871 - 12876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Mamidipudi, X. Li, and M. W. Wooten Identification of Interleukin 1 Receptor-associated Kinase as a Conserved Component in the p75-Neurotrophin Receptor Activation of Nuclear Factor-kappa B J. Biol. Chem., July 26, 2002; 277(31): 28010 - 28018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. C. Xu, R. F. Wu, Y. Gu, Y.-S. Yang, M.-C. Yang, F. E. Nwariaku, and L. S. Terada Involvement of TRAF4 in Oxidative Activation of c-Jun N-terminal Kinase J. Biol. Chem., July 26, 2002; 277(31): 28051 - 28057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Zapata and J. C. Reed TRAF1: Lord Without A RING Sci. Signal., May 21, 2002; 2002(133): pe27 - pe27. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Y. Chung, Y. C. Park, H. Ye, and H. Wu All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction J. Cell Sci., February 15, 2002; 115(4): 679 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Towb, A. Bergmann, and S. A. Wasserman The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway Development, December 1, 2001; 128(23): 4729 - 4736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Silverman and T. Maniatis NF-{kappa}B signaling pathways in mammalian and insect innate immunity Genes & Dev., September 15, 2001; 15(18): 2321 - 2342. [Full Text] [PDF]
|
|
|
|
|
|
B. Shen, H. Liu, E. Y. Skolnik, and J. L. Manley Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation PNAS, July 5, 2001; (2001) 141235698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Zapata, K. Pawlowski, E. Haas, C. F. Ware, A. Godzik, and J. C. Reed A Diverse Family of Proteins Containing Tumor Necrosis Factor Receptor-associated Factor Domains J. Biol. Chem., June 22, 2001; 276(26): 24242 - 24252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Shen, H. Liu, E. Y. Skolnik, and J. L. Manley Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation PNAS, July 17, 2001; 98(15): 8596 - 8601. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
