|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 275, Issue 17, 12475-12480, April 28, 2000
From the Expression of the kinin B1 receptor is
up-regulated in chronic inflammatory and fibrotic disorders; however,
little is known about its role in fibrogenesis. We examined human
embryonic lung fibroblasts that constitutively express the B1 receptor
and report that engagement of the B1 receptor by
des-Arg10-kallidin stabilized connective tissue
growth factor (CTGF) mRNA, stimulated an increase in
Des-Arg10-kallidin Engagement of the B1 Receptor
Stimulates Type I Collagen Synthesis via Stabilization of
Connective Tissue Growth Factor mRNA*
§,
,**, and
Pulmonary Center, Departments of Medicine
and Biochemistry, Boston University School of Medicine and the
Boston Veterans Affairs Medical Center and the
¶ Endocrine-Hypertension Division, Department of Medicine, Harvard
Medical School, Boston, Massachusetts 02118-2394
1(I)
collagen mRNA, and stimulated type I collagen production. These
events were not observed in B2 receptor-activated fibroblasts. In
addition, B1 receptor activation by des-Arg10-kallidin
induced a rise in cytosolic Ca2+ that is consistent with B1
receptor pharmacology. Our results show that the
des-Arg10-kallidin-stimulated increase in 1(I) collagen
mRNA was time- and dose-dependent, with a peak response
observed at 20 h with 100 nM
des-Arg10-kallidin. The increase in CTGF mRNA was also
time- and dose-dependent, with a peak response observed at
4 h with 100 nM des-Arg10-kallidin. The
increase in CTGF mRNA was blocked by the B1 receptor antagonist
des-Arg10,Leu9-kallidin. Inhibition of protein
synthesis by cycloheximide did not block the
des-Arg10-kallidin-induced increase in CTGF mRNA. These
results suggest that engagement of the kinin B1 receptor contributes to
fibrogenesis through increased expression of CTGF.
*
This work was supported in part by NHLBI Grant P50HL56386
from the National Institutes of Health and by the Veterans Affairs Medical Center Merit Review Research Program.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Supported by NIDDK Grant R03DK53538 from the National
Institutes of Health.
**
Boston Veterans Affairs Medical Center Research Enhancement Awards
Program Fellow.
§
To whom correspondence should be addressed: Pulmonary Center,
Boston University School of Medicine, 715 Albany St., R3, Boston, MA
02118-2394. Tel.: 617-638-4860; Fax: 617-536-8093l; E-mail: ricupero@ bu.edu.
Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Westermann, T. Walther, K. Savvatis, F. Escher, M. Sobirey, A. Riad, M. Bader, H.-P. Schultheiss, and C. Tschope Gene Deletion of the Kinin Receptor B1 Attenuates Cardiac Inflammation and Fibrosis During the Development of Experimental Diabetic Cardiomyopathy Diabetes, June 1, 2009; 58(6): 1373 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Klein, J. Gonzalez, J. Duchene, L. Esposito, J. P. Pradere, E. Neau, C. Delage, D. Calise, A. Ahluwalia, P. Carayon, et al. Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy FASEB J, January 1, 2009; 23(1): 134 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Helske, M. Laine, M. Kupari, J. Lommi, H. Turto, L. Nurmi, I. Tikkanen, K. Werkkala, K. A. Lindstedt, and P. T. Kovanen Increased expression of profibrotic neutral endopeptidase and bradykinin type 1 receptors in stenotic aortic valves Eur. Heart J., August 1, 2007; 28(15): 1894 - 1903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Phagoo, K. Reddi, B. J. Silvallana, L. M. F. Leeb-Lundberg, and D. Warburton Infection-Induced Kinin B1 Receptors in Human Pulmonary Fibroblasts: Role of Intact Pathogens and p38 Mitogen-Activated Protein Kinase-Dependent Signaling J. Pharmacol. Exp. Ther., June 1, 2005; 313(3): 1231 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Liesmaa, A. Kuoppala, N. Shiota, J. O. Kokkonen, K. Kostner, M. Mayranpaa, P. T. Kovanen, and K. A. Lindstedt Increased expression of bradykinin type-1 receptors in endothelium of intramyocardial coronary vessels in human failing hearts Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2317 - H2322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Romero, A. Rivera, V. Lanca, M. D. P. Bicho, P. R. Conlin, and D. A. Ricupero Na+/Ca2+ Exchanger Activity Modulates Connective Tissue Growth Factor mRNA Expression in Transforming Growth Factor {beta}1- and Des-Arg10-kallidin-stimulated Myofibroblasts J. Biol. Chem., April 15, 2005; 280(15): 14378 - 14384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. F. Leeb-Lundberg, F. Marceau, W. Muller-Esterl, D. J. Pettibone, and B. L. Zuraw International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences Pharmacol. Rev., March 1, 2005; 57(1): 27 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Del Rosso, O Distler, A F Milia, C Emanueli, L Ibba-Manneschi, S Guiducci, M L Conforti, S Generini, A Pignone, S Gay, et al. Increased circulating levels of tissue kallikrein in systemic sclerosis correlate with microvascular involvement Ann Rheum Dis, March 1, 2005; 64(3): 382 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Morissette, J.-P. Fortin, S. Otis, J. Bouthillier, and F. Marceau A Novel Nonpeptide Antagonist of the Kinin B1 Receptor: Effects at the Rabbit Receptor J. Pharmacol. Exp. Ther., December 1, 2004; 311(3): 1121 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Iwanciw, M. Rehm, M. Porst, and M. Goppelt-Struebe Induction of Connective Tissue Growth Factor by Angiotensin II: Integration of Signaling Pathways Arterioscler. Thromb. Vasc. Biol., October 1, 2003; 23(10): 1782 - 1787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Utsugi, K. Dobashi, T. Ishizuka, K. Masubuchi, Y. Shimizu, T. Nakazawa, and M. Mori C-Jun-NH2-Terminal Kinase Mediates Expression of Connective Tissue Growth Factor Induced by Transforming Growth Factor-{beta}1 in Human Lung Fibroblasts Am. J. Respir. Cell Mol. Biol., June 1, 2003; 28(6): 754 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Harlow, L. Davidson, K. H. Burns, C. Yan, M. M. Matzuk, and S. G. Hillier FSH and TGF-{beta} Superfamily Members Regulate Granulosa Cell Connective Tissue Growth Factor Gene Expression in Vitro and in Vivo Endocrinology, September 1, 2002; 143(9): 3316 - 3325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Christiansen, J. Eddleston, K. M. Woessner, S. S. Chambers, R. Ye, Z. K. Pan, and B. L. Zuraw Up-Regulation of Functional Kinin B1 Receptors in Allergic Airway Inflammation J. Immunol., August 15, 2002; 169(4): 2054 - 2060. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. HEUSINGER-RIBEIRO, M. EBERLEIN, N. A. WAHAB, and M. GOPPELT-STRUEBE Expression of Connective Tissue Growth Factor in Human Renal Fibroblasts: Regulatory Roles of RhoA and cAMP J. Am. Soc. Nephrol., September 1, 2001; 12(9): 1853 - 1861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. KONDO, S. KAGAMI, H. KIDO, F. STRUTZ, G. A. MULLER, and Y. KURODA Role of Mast Cell Tryptase in Renal Interstitial Fibrosis J. Am. Soc. Nephrol., August 1, 2001; 12(8): 1668 - 1676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hahn, J. Heusinger-Ribeiro, T. Lanz, S. Zenkel, and M. Goppelt-Struebe Induction of Connective Tissue Growth Factor by Activation of Heptahelical Receptors. MODULATION BY Rho PROTEINS AND THE ACTIN CYTOSKELETON J. Biol. Chem., November 22, 2000; 275(48): 37429 - 37435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Suzuma, K. Naruse, I. Suzuma, N. Takahara, K. Ueki, L. P. Aiello, and G. L. King Vascular Endothelial Growth Factor Induces Expression of Connective Tissue Growth Factor via KDR, Flt1, and Phosphatidylinositol 3-Kinase-Akt-dependent Pathways in Retinal Vascular Cells J. Biol. Chem., December 22, 2000; 275(52): 40725 - 40731. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |