JBC Transcription and Nuclear Factor Monoclonals

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Soutoglou, E.
Right arrow Articles by Talianidis, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Soutoglou, E.
Right arrow Articles by Talianidis, I.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

J Biol Chem, Vol. 275, Issue 17, 12515-12520, April 28, 2000

Transcriptional Activation by Hepatocyte Nuclear Factor-1 Requires Synergism between Multiple Coactivator Proteins*

Evi SoutoglouDagger , George PapafotiouDagger , Nitsa Katrakili, and Iannis Talianidis§

From the Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, 711 10 Herakleion Crete, Greece

Hepatocyte nuclear factor-1 (HNF-1) plays an important role in the regulation of a large number of genes expressed in the liver, kidney, and pancreatic beta -cells. In exploring the molecular mechanism involved in HNF-1-dependent gene activation in the in vivo chromatin context, we found that HNF-1 can physically interact with the histone acetyltransferases (HATs) CREB-binding protein (CBP), p300/CBP-associated factor (P/CAF), Src-1, and RAC3. The transcriptional activation potential of HNF-1 on a genome integrated promoter was strictly dependent on the synergistic action of CBP and P/CAF, which can independently interact with the N-terminal and C-terminal domain of HNF-1, respectively. Moreover, the HAT activity of both coactivators was important, as opposed to the selective requirement for the HAT activity of P/CAF in activation from a transiently transfected reporter. Interaction of CBP with the N-terminal domain of HNF-1 greatly increased the binding affinity for P/CAF with the C-terminal activation domain, which may represent the molecular basis for the observed functional synergism. The results support a model that involves the combined action of multiple coactivators recruited by HNF-1, which activate transcription by coupling nucleosome modification and recruitment of the general transcription machinery.

* This work was supported by funds from the Greek General Secretariat for Science and Technology.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger Supported by the Joint Graduate Program in Molecular Biology and Biomedicine of the Greek Ministry of Education.

§ To whom correspondence should be addressed: Inst. of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, P.O. Box 1527, 711 10 Herakleion Crete, Greece. Tel.: 30-81-391173; Fax: 30-81-391101; E-mail: talianid@nefeli.imbb.forth.gr.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
M. Yu, J. Wang, W. Li, Y. Z. Yuan, C. Y. Li, X. H. Qian, W. X. Xu, Y. Q. Zhan, and X. M. Yang
Proteomic screen defines the hepatocyte nuclear factor 1{alpha}-binding partners and identifies HMGB1 as a new cofactor of HNF1{alpha}
Nucleic Acids Res., March 27, 2008; 36(4): 1209 - 1219.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Hiroki, S. A. Liebhaber, and N. E. Cooke
An Intronic Locus Control Region Plays an Essential Role in the Establishment of an Autonomous Hepatic Chromatin Domain for the Human Vitamin D-Binding Protein Gene
Mol. Cell. Biol., November 1, 2007; 27(21): 7365 - 7380.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. F. Luco, M. A. Maestro, N. del Pozo, W. M. Philbrick, P. P. de la Ossa, and J. Ferrer
A Conditional Model Reveals That Induction of Hepatocyte Nuclear Factor-1{alpha} in Hnf1{alpha}-Null Mutant {beta}-Cells Can Activate Silenced Genes Postnatally, Whereas Overexpression Is Deleterious.
Diabetes, August 1, 2006; 55(8): 2202 - 2211.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Hoffmann, T. Barz, and D. Spengler
Multitasking C2H2 Zinc Fingers Link Zac DNA Binding to Coordinated Regulation of p300-Histone Acetyltransferase Activity.
Mol. Cell. Biol., July 1, 2006; 26(14): 5544 - 5557.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. K. Yang, J. H. Kim, H. Li, and M. R. Stallcup
Differential Use of Functional Domains by Coiled-coil Coactivator in Its Synergistic Coactivator Function with beta-Catenin or GRIP1
J. Biol. Chem., February 10, 2006; 281(6): 3389 - 3397.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-i. Satoh, T. Noaki, T. Ishigure, S. Osada, M. Imagawa, N. Miura, K. Yamada, and T. Noguchi
Nuclear Factor 1 Family Members Interact with Hepatocyte Nuclear Factor 1{alpha} to Synergistically Activate L-type Pyruvate Kinase Gene Transcription
J. Biol. Chem., December 2, 2005; 280(48): 39827 - 39834.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. T. Vander Kooi, H. Onuma, J. K. Oeser, C. A. Svitek, S. R. Allen, C. W. Vander Kooi, W. J. Chazin, and R. M. O'Brien
The Glucose-6-Phosphatase Catalytic Subunit Gene Promoter Contains Both Positive and Negative Glucocorticoid Response Elements
Mol. Endocrinol., December 1, 2005; 19(12): 3001 - 3022.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Puppin, F. D'Aurizio, A. V. D'Elia, L. Cesaratto, G. Tell, D. Russo, S. Filetti, E. Ferretti, E. Tosi, T. Mattei, et al.
Effects of Histone Acetylation on Sodium Iodide Symporter Promoter and Expression of Thyroid-Specific Transcription Factors
Endocrinology, September 1, 2005; 146(9): 3967 - 3974.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Xu, M. Capezzone, X. Xu, and J. M. Hershman
Activation of Nicotinamide N-Methyltransferase Gene Promoter by Hepatocyte Nuclear Factor-1{beta} in Human Papillary Thyroid Cancer Cells
Mol. Endocrinol., February 1, 2005; 19(2): 527 - 539.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
L. Wang, A. Klopot, J.-N. Freund, L. N. Dowling, S. D. Krasinski, and J. C. Fleet
Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1{alpha}
Am J Physiol Gastrointest Liver Physiol, November 1, 2004; 287(5): G943 - G953.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. M. Rausa III, D. E. Hughes, and R. H. Costa
Stability of the Hepatocyte Nuclear Factor 6 Transcription Factor Requires Acetylation by the CREB-binding Protein Coactivator
J. Biol. Chem., October 8, 2004; 279(41): 43070 - 43076.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
T. Dohda, H. Kaneoka, Y. Inayoshi, M. Kamihira, K. Miyake, and S. Iijima
Transcriptional Coactivators CBP and p300 Cooperatively Enhance HNF-1{alpha}-Mediated Expression of the Albumin Gene in Hepatocytes
J. Biochem., September 1, 2004; 136(3): 313 - 319.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. Eeckhoute, P. Formstecher, and B. Laine
Hepatocyte Nuclear Factor 4{alpha} enhances the Hepatocyte Nuclear Factor 1{alpha}-mediated activation of transcription
Nucleic Acids Res., May 11, 2004; 32(8): 2586 - 2593.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Kitanaka, Y. Miki, Y. Hayashi, and T. Igarashi
Promoter-Specific Repression of Hepatocyte Nuclear Factor (HNF)-1{beta} and HNF-1{alpha} Transcriptional Activity by an HNF-1{beta} Missense Mutant Associated with Type 5 Maturity-Onset Diabetes of the Young with Hepatic and Biliary Manifestations
J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1369 - 1378.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. Gerrish, J. C. Van Velkinburgh, and R. Stein
Conserved Transcriptional Regulatory Domains of the pdx-1 Gene
Mol. Endocrinol., March 1, 2004; 18(3): 533 - 548.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Sanyal, J. Matthews, D. Bouton, H.-J. Kim, H.-S. Choi, E. Treuter, and J.-A. Gustafsson
Deoxyribonucleic Acid Response Element-Dependent Regulation of Transcription by Orphan Nuclear Receptor Estrogen Receptor-Related Receptor {gamma}
Mol. Endocrinol., February 1, 2004; 18(2): 312 - 325.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. B. Smith, R. Gasa, H. Watada, J. Wang, S. C. Griffen, and M. S. German
Neurogenin3 and Hepatic Nuclear Factor 1 Cooperate in Activating Pancreatic Expression of Pax4
J. Biol. Chem., October 3, 2003; 278(40): 38254 - 38259.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. K. Chakrabarti, J. Francis, S. M. Ziesmann, J. C. Garmey, and R. G. Mirmira
Covalent Histone Modifications Underlie the Developmental Regulation of Insulin Gene Transcription in Pancreatic {beta} Cells
J. Biol. Chem., June 20, 2003; 278(26): 23617 - 23623.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Schjerven, P. Brandtzaeg, and F.-E. Johansen
Hepatocyte NF-1 and STAT6 Cooperate with Additional DNA-Binding Factors to Activate Transcription of the Human Polymeric Ig Receptor Gene in Response to IL-4
J. Immunol., June 15, 2003; 170(12): 6048 - 6056.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. L. Mosley and S. Ozcan
Glucose Regulates Insulin Gene Transcription by Hyperacetylation of Histone H4
J. Biol. Chem., May 23, 2003; 278(22): 19660 - 19666.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Li, T. L. Zimmerman, S. Thevananther, H.-Y. Lee, J. M. Kurie, and S. J. Karpen
Interleukin-1beta -mediated Suppression of RXR:RAR Transactivation of the Ntcp Promoter Is JNK-dependent
J. Biol. Chem., August 23, 2002; 277(35): 31416 - 31422.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Boudreau, E. H. H. M. Rings, H. M. van Wering, R. K. Kim, G. P. Swain, S. D. Krasinski, J. Moffett, R. J. Grand, E. R. Suh, and P. G. Traber
Hepatocyte Nuclear Factor-1alpha , GATA-4, and Caudal Related Homeodomain Protein Cdx2 Interact Functionally to Modulate Intestinal Gene Transcription. IMPLICATION FOR THE DEVELOPMENTAL REGULATION OF THE SUCRASE-ISOMALTASE GENE
J. Biol. Chem., August 23, 2002; 277(35): 31909 - 31917.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. M. van Wering, I. L. Huibregtse, S. M. van der Zwan, M. S. de Bie, L. N. Dowling, F. Boudreau, E. H. H. M. Rings, R. J. Grand, and S. D. Krasinski
Physical Interaction between GATA-5 and Hepatocyte Nuclear Factor-1alpha Results in Synergistic Activation of the Human Lactase-Phlorizin Hydrolase Promoter
J. Biol. Chem., July 26, 2002; 277(31): 27659 - 27667.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Lim, K. Jin, and E. Friedman
Mirk Protein Kinase Is Activated by MKK3 and Functions as a Transcriptional Activator of HNF1alpha
J. Biol. Chem., July 5, 2002; 277(28): 25040 - 25046.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
N. Ban, Y. Yamada, Y. Someya, K. Miyawaki, Y. Ihara, M. Hosokawa, S. Toyokuni, K. Tsuda, and Y. Seino
Hepatocyte Nuclear Factor-1{alpha} Recruits the Transcriptional Co-Activator p300 on the GLUT2 Gene Promoter
Diabetes, May 1, 2002; 51(5): 1409 - 1418.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
H. Schrem, J. Klempnauer, and J. Borlak
Liver-Enriched Transcription Factors in Liver Function and Development. Part I: The Hepatocyte Nuclear Factor Network and Liver-Specific Gene Expression
Pharmacol. Rev., March 1, 2002; 54(1): 129 - 158.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Qiu, M. Guo, S. Huang, and R. Stein
Insulin Gene Transcription Is Mediated by Interactions between the p300 Coactivator and PDX-1, BETA2, and E47
Mol. Cell. Biol., January 15, 2002; 22(2): 412 - 420.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
F. Oswald, B. Tauber, T. Dobner, S. Bourteele, U. Kostezka, G. Adler, S. Liptay, and R. M. Schmid
p300 Acts as a Transcriptional Coactivator for Mammalian Notch-1
Mol. Cell. Biol., November 15, 2001; 21(22): 7761 - 7774.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Aranda and A. Pascual
Nuclear Hormone Receptors and Gene Expression
Physiol Rev, July 1, 2001; 81(3): 1269 - 1304.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Párrizas, M. A. Maestro, S. F. Boj, A. Paniagua, R. Casamitjana, R. Gomis, F. Rivera, and J. Ferrer
Hepatic Nuclear Factor 1-{alpha} Directs Nucleosomal Hyperacetylation to Its Tissue-Specific Transcriptional Targets
Mol. Cell. Biol., May 1, 2001; 21(9): 3234 - 3243.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
S. L. Wyszomierski and J. M. Rosen
Cooperative Effects of STAT5 (Signal Transducer and Activator of Transcription 5) and C/EBP {beta} (CCAAT/Enhancer-Binding Protein-{beta}) on {beta}-Casein Gene Transcription Are Mediated by the Glucocorticoid Receptor
Mol. Endocrinol., February 1, 2001; 15(2): 228 - 240.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
J. I. Leu, M. A. S. Crissey, J. P. Leu, G. Ciliberto, and R. Taub
Interleukin-6-Induced STAT3 and AP-1 Amplify Hepatocyte Nuclear Factor 1-Mediated Transactivation of Hepatic Genes, an Adaptive Response to Liver Injury
Mol. Cell. Biol., January 15, 2001; 21(2): 414 - 424.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
J. M. Stafford, M. Waltner-Law, and D. K. Granner
Role of Accessory Factors and Steroid Receptor Coactivator 1 in the Regulation of Phosphoenolpyruvate Carboxykinase Gene Transcription by Glucocorticoids
J. Biol. Chem., February 2, 2001; 276(6): 3811 - 3819.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Boudreau, Y. Zhu, and P. G. Traber
Sucrase-isomaltase Gene Transcription Requires the Hepatocyte Nuclear Factor-1 (HNF-1) Regulatory Element and Is Regulated by the Ratio of HNF-1alpha to HNF-1beta
J. Biol. Chem., August 17, 2001; 276(34): 32122 - 32128.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Jung, B. Hagenbuch, L. Gresh, M. Pontoglio, P. J. Meier, and G. A. Kullak-Ublick
Characterization of the Human OATP-C (SLC21A6) Gene Promoter and Regulation of Liver-specific OATP Genes by Hepatocyte Nuclear Factor 1alpha
J. Biol. Chem., September 28, 2001; 276(40): 37206 - 37214.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2000 by the American Society for Biochemistry and Molecular Biology.