|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 275, Issue 17, 13134-13141, April 28, 2000
From the Progression through the cell cycle requires ATP
for protein synthesis, cytoskeletal rearrangement, chromatin
remodeling, and protein degradation. The mechanisms by which mammalian
cells increase respiratory capacity and ATP production in preparation
for cell division are largely unexplored. Here, we demonstrate that
serum induction of cytochrome c mRNA and processed
protein in quiescent BALB/3T3 fibroblasts is associated with a marked
increase in mitochondrial respiration. Cytochrome c was
induced in the absence of any increase in citrate synthase activity or
in subunit IV of the cytochrome c oxidase complex mRNA
or protein, indicating that the enhanced respiratory rate did not
require a general increase in mitochondrial biogenesis or respiratory
chain expression. Transfections with a series of cytochrome
c promoter mutants showed that both nuclear respiratory
factor 1 (NRF-1) and cAMP-response element-binding protein (CREB)
binding sites contributed equally to induced expression by serum.
Moreover, CREB and NRF-1 were phosphorylated sequentially in response
to serum, and the NRF-1 phosphorylation was accompanied by an increase
in its ability to trans-activate target gene expression. The results demonstrate that the differential transcriptional expression of cytochrome c, through sequential
transcription factor phosphorylations, leads to enhanced mitochondrial
respiratory capacity upon serum-induced entry to the cell cycle.
Sequential Serum-dependent Activation of CREB and
NRF-1 Leads to Enhanced Mitochondrial Respiration through the Induction
of Cytochrome c*
,¶
Department of Cell and Molecular Biology,
Northwestern Medical School, Chicago, Illinois 60611 and the
§ Institute of Medical Biochemistry and Chemistry,
University of Bari, Piazza G. Cesare, 70124 Bari, Italy
*
This work was supported by United States Public Health
Service Grant GM32525-17 from the National Institutes of Health.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  V. E. Jahnke, O. Sabido, and D. Freyssenet Control of mitochondrial biogenesis, ROS level, and cytosolic Ca2+ concentration during the cell cycle and the onset of differentiation in L6E9 myoblasts Am J Physiol Cell Physiol, May 1, 2009; 296(5): C1185 - C1194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hallberg, D. L. Morganstein, E. Kiskinis, K. Shah, A. Kralli, S. M. Dilworth, R. White, M. G. Parker, and M. Christian A Functional Interaction between RIP140 and PGC-1{alpha} Regulates the Expression of the Lipid Droplet Protein CIDEA Mol. Cell. Biol., November 15, 2008; 28(22): 6785 - 6795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ramachandran, G. Yu, and T. Gulick Nuclear Respiratory Factor 1 Controls Myocyte Enhancer Factor 2A Transcription to Provide a Mechanism for Coordinate Expression of Respiratory Chain Subunits J. Biol. Chem., May 2, 2008; 283(18): 11935 - 11946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Scarpulla Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function Physiol Rev, April 1, 2008; 88(2): 611 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Franko, S. Mayer, G. Thiel, L. Mercy, T. Arnould, H.-T. Hornig-Do, R. J. Wiesner, and S. Goffart CREB-1{alpha} Is Recruited to and Mediates Upregulation of the Cytochrome c Promoter during Enhanced Mitochondrial Biogenesis Accompanying Skeletal Muscle Differentiation Mol. Cell. Biol., April 1, 2008; 28(7): 2446 - 2459. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Watson, J. E. B. Reusch, S. A. McCune, L. A. Leinwand, S. W. Luckey, J. P. Konhilas, D. A. Brown, A. J. Chicco, G. C. Sparagna, C. S. Long, et al. Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H246 - H259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Srivastava, J. N. Barrett, and C. T. Moraes PGC-1{alpha}/{beta} upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations Hum. Mol. Genet., April 15, 2007; 16(8): 993 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Chamberlin Changes in mitochondrial electron transport chain activity during insect metamorphosis Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R1016 - R1022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. A. Oliveira, S. Chen, S. Almeida, R. Riley, J. Goncalves, C. R. Oliveira, M. R. Hayden, D. G. Nicholls, L. M. Ellerby, and A. C. Rego Mitochondrial-Dependent Ca2+ Handling in Huntington's Disease Striatal Cells: Effect of Histone Deacetylase Inhibitors J. Neurosci., October 25, 2006; 26(43): 11174 - 11186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Vercauteren, R. A. Pasko, N. Gleyzer, V. M. Marino, and R. C. Scarpulla PGC-1-Related Coactivator: Immediate Early Expression and Characterization of a CREB/NRF-1 Binding Domain Associated with Cytochrome c Promoter Occupancy and Respiratory Growth Mol. Cell. Biol., October 15, 2006; 26(20): 7409 - 7419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Wu, X. Huang, Y. Feng, C. Handschin, Y. Feng, P. S. Gullicksen, O. Bare, M. Labow, B. Spiegelman, and S. C. Stevenson Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1{alpha} transcription and mitochondrial biogenesis in muscle cells PNAS, September 26, 2006; 103(39): 14379 - 14384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wang, Z. Li, Y. Lu, R. Du, S. Katiyar, J. Yang, M. Fu, J. E. Leader, A. Quong, P. M. Novikoff, et al. Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function PNAS, August 1, 2006; 103(31): 11567 - 11572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Kraft, C. M. R. LeMoine, C. N. Lyons, D. Michaud, C. R. Mueller, and C. D. Moyes Control of mitochondrial biogenesis during myogenesis Am J Physiol Cell Physiol, April 1, 2006; 290(4): C1119 - C1127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. López-Lluch, N. Hunt, B. Jones, M. Zhu, H. Jamieson, S. Hilmer, M. V. Cascajo, J. Allard, D. K. Ingram, P. Navas, et al. Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency PNAS, February 7, 2006; 103(6): 1768 - 1773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Duckles, D. N. Krause, C. Stirone, and V. Procaccio Estrogen and mitochondria: a new paradigm for vascular protection? Mol. Interv., February 1, 2006; 6(1): 26 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Piantadosi and H. B. Suliman Mitochondrial Transcription Factor A Induction by Redox Activation of Nuclear Respiratory Factor 1 J. Biol. Chem., January 6, 2006; 281(1): 324 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Stirone, S. P. Duckles, D. N. Krause, and V. Procaccio Estrogen Increases Mitochondrial Efficiency and Reduces Oxidative Stress in Cerebral Blood Vessels Mol. Pharmacol., October 1, 2005; 68(4): 959 - 965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gleyzer, K. Vercauteren, and R. C. Scarpulla Control of Mitochondrial Transcription Specificity Factors (TFB1M and TFB2M) by Nuclear Respiratory Factors (NRF-1 and NRF-2) and PGC-1 Family Coactivators Mol. Cell. Biol., February 15, 2005; 25(4): 1354 - 1366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Goffart, J.-C. von Kleist-Retzow, and R. J. Wiesner Regulation of mitochondrial proliferation in the heart: power-plant failure contributes to cardiac failure in hypertrophy Cardiovasc Res, November 1, 2004; 64(2): 198 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. McLeod, A. P. Jeyabalan, J. O. Minners, R. Clevenger, R. F. Hoyt Jr, and M. N. Sack Delayed Ischemic Preconditioning Activates Nuclear-Encoded Electron-Transfer-Chain Gene Expression in Parallel With Enhanced Postanoxic Mitochondrial Respiratory Recovery Circulation, August 3, 2004; 110(5): 534 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Simon, C. Arthur, A. L. Fong, J. M. Dwyer, M. Davare, E. Reese, K. Obrietan, and S. Impey Mitogen- and Stress-Activated Protein Kinase 1 Mediates cAMP Response Element-Binding Protein Phosphorylation and Activation by Neurotrophins J. Neurosci., May 5, 2004; 24(18): 4324 - 4332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Takeuchi and T. Ueda Down-regulation of the Mitochondrial Translation System during Terminal Differentiation of HL-60 cells by 12-O-Tetradecanoyl-1-phorbol-13-acetate: COMPARISON WITH THE CYTOPLASMIC TRANSLATION SYSTEM J. Biol. Chem., November 14, 2003; 278(46): 45318 - 45324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Gybina and J. R. Prohaska Increased Rat Brain Cytochrome C Correlates with Degree of Perinatal Copper Deficiency Rather than Apoptosis J. Nutr., November 1, 2003; 133(11): 3361 - 3368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. BAAR, Z. SONG, C. F. SEMENKOVICH, T. E. JONES, D.-H. HAN, L. A. NOLTE, E. O. OJUKA, M. CHEN, and J. O. HOLLOSZY Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity FASEB J, September 1, 2003; 17(12): 1666 - 1673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.-J. Huang, S. A. Price, L. Chilton, N. A. Calcutt, D. R. Tomlinson, A. Verkhratsky, and P. Fernyhough Insulin Prevents Depolarization of the Mitochondrial Inner Membrane in Sensory Neurons of Type 1 Diabetic Rats in the Presence of Sustained Hyperglycemia Diabetes, August 1, 2003; 52(8): 2129 - 2136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Elkon, C. Linhart, R. Sharan, R. Shamir, and Y. Shiloh Genome-Wide In Silico Identification of Transcriptional Regulators Controlling the Cell Cycle in Human Cells Genome Res., May 1, 2003; 13(5): 773 - 780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gines, I. S. Seong, E. Fossale, E. Ivanova, F. Trettel, J. F. Gusella, V. C. Wheeler, F. Persichetti, and M. E. MacDonald Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice Hum. Mol. Genet., March 1, 2003; 12(5): 497 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Morrish, C. Giedt, and D. Hockenbery c-MYC apoptotic function is mediated by NRF-1 target genes Genes & Dev., January 15, 2003; 17(2): 240 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Duguez, L. Feasson, C. Denis, and D. Freyssenet Mitochondrial biogenesis during skeletal muscle regeneration Am J Physiol Endocrinol Metab, April 1, 2002; 282(4): E802 - E809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Yeh, P. Lecine, J. A. Nunes, S. Spicuglia, P. Ferrier, D. Olive, and J. Imbert Novel CD28-Responsive Enhancer Activated by CREB/ATF and AP-1 Families in the Human Interleukin-2 Receptor {alpha}-Chain Locus Mol. Cell. Biol., July 15, 2001; 21(14): 4515 - 4527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Hood Plasticity in Skeletal, Cardiac, and Smooth Muscle: Invited Review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle J Appl Physiol, March 1, 2001; 90(3): 1137 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Scacco, R. Vergari, R. C. Scarpulla, Z. Technikova-Dobrova, A. Sardanelli, R. Lambo, V. Lorusso, and S. Papa cAMP-dependent Phosphorylation of the Nuclear Encoded 18-kDa (IP) Subunit of Respiratory Complex I and Activation of the Complex in Serum-starved Mouse Fibroblast Cultures J. Biol. Chem., June 2, 2000; 275(23): 17578 - 17582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. K. Fazio, T. A. Bolger, and G. Gill Conserved Regions of the Drosophila Erect Wing Protein Contribute Both Positively and Negatively to Transcriptional Activity J. Biol. Chem., May 25, 2001; 276(22): 18710 - 18716. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |