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J Biol Chem, Vol. 275, Issue 18, 13398-13405, May 5, 2000
From the We examined the in vivo expression of
up to 16 genes encoding for components of both glutaredoxin and
thioredoxin systems and for members of the OxyR and SoxRS regulons. We
demonstrated that grxA (Grx1) transcription is triggered in
bacteria lacking Trx1 (trxA) and GSH (gshA) in
an OxyR-dependent manner. We also indicated that, unlike
OxyR, SoxR is not constitutively activated in the oxidizing environment
of trxA gshA mutants. We discovered that the lack of Trx1
plus GSH increases the steady-state levels of Trx reductase
(trxB) and Trx2 (trxC) transcripts. This
increase and the trxB and trxC up-regulation
caused by the constitutive oxyR2 allele indicate that OxyR
also plays a role in the regulation of the thioredoxin pathway. On the
contrary, no change in the expression of genes for Trx1, Grx2, and Grx3
was observed. Transcription of nrdAB (RRase) was not
induced by oxidative stress yet was induced by hydroxyurea (RRase
inhibitor). Induction level was as the enhanced nrdAB basal
expression of trxA grxA mutants, indicating that RRase operation without Trx1 and Grx1 must lead to disturbances sensed as
those caused by hydroxyurea. We also demonstrated an inverse relation
between nrdAB expression and that of genes coding for components of both glutaredoxin (grxA, gorA)
and thioredoxin (trxB, trxC) systems.
Transcriptional Regulation of Glutaredoxin and Thioredoxin
Pathways and Related Enzymes in Response to Oxidative Stress*
,§,,¶,
, and**
Departamento de Bioquímica y
Biología Molecular, Universidad de Córdoba,
14071-Córdoba, España and the Medical Nobel
Institute for Biochemistry, Department of Medical Biochemistry and
Biophysics, Karolinska Institute, S-171 77, Stockholm, Sweden
*
This work was supported by Junta de Andalucía (group
CVI 0187) Grants PB95-0557-CO2-01 and PB98-1627 (to D. G. E. S.) and by the Swedish Cancer Society.The costs of publication of this article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
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