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J Biol Chem, Vol. 275, Issue 19, 14102-14106, May 12, 2000
From the A full-length cDNA encoding a SUMO-1-specific
protease, named SUSP1, was identified and cloned for the first time
from the human brain. Nucleotide sequence analysis of the cDNA
containing an open reading frame of 3336 base pairs revealed that the
protease consists of 1112 amino acids with a calculated molecular mass of 126,116 Da. Like yeast Ulp1, SUSP1 is a cysteine protease containing the well conserved His/Asp/Cys catalytic triad. SUSP1 expressed in
Escherichia coli cells efficiently released SUMO-1 from
SUMO-1· The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AF196304.
A New SUMO-1-specific Protease, SUSP1, That Is Highly
Expressed in Reproductive Organs*
,,,
,,§§
School of Biological Sciences and Research
Center for Cell Differentiation, Seoul National University,
Seoul 151-742, Korea, the § Department of Internal
Medicine, University of Tokyo Branch Hospital, Tokyo 112-8688, Japan,
¶ Tokyo Metropolitan Institute of Medical Science, CREST, Japan
Science and Technology Corp. Tokyo 113-8613, Japan, the
Biomedical R & D Department, Sumitomo Electrical Industries,
Yokohama 244-8588, Japan, and the ** Picower Institute for Medical
Research, Manhasset, New York 11030
-galactosidase fusion but not from other ubiquitin-like
protein fusions, including Smt3·-galactosidase, suggesting its
role in the generation of matured SUMO-1 specifically from its
precursors. Interestingly, reproductive organs, such as testis, ovary,
and prostate, contained much higher amounts of SUSP1 mRNA than
colon and peripheral blood leukocyte, whereas other tissues, such as
heart and spleen, had little or none. In addition, confocal microscopy
using green fluorescent protein·SUSP1 fusion showed that SUSP1 is
exclusively localized to the cytoplasm of NIH3T3 and HeLa cells. These
results suggest that SUSP1 may play a role in the regulation of
SUMO-1-mediated cellular processes particularly related to reproduction.
*
This work was supported by grants from the Korea Science and
Engineering Foundation through the (BK Program Research Center for Cell
Differentiation, Korea Ministry of Education, and CREST, Japan Science
and Technology Corporation.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
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