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J Biol Chem, Vol. 275, Issue 19, 14501-14508, May 12, 2000
From the We used muscle contraction, which increases fatty
acid oxidation, as a model to determine whether fatty acid transport is acutely regulated by fatty acid translocase (FAT/CD36). Palmitate uptake by giant vesicles, obtained from skeletal muscle, was increased by muscle contraction. Kinetic studies indicated that muscle
contraction increased Vmax, but
Km remained unaltered.
Sulfo-N-succinimidyl oleate, a specific inhibitor of
FAT/CD36, fully blocked the contraction-induced increase in palmitate
uptake. In giant vesicles from contracting muscles, plasma membrane
FAT/CD36 was also increased in parallel with the increase in long chain
fatty acid uptake. Further studies showed that like GLUT-4, FAT/CD36 is
located in both the plasma membrane and intracellularly (endosomally).
With muscle contraction, FAT/CD36 at the surface of the muscle was
increased, while concomitantly, FAT/CD36 in the intracellular pool was
reduced. Similar responses were observed for GLUT-4. We conclude that
fatty acid uptake is subject to short term regulation by muscle
contraction and involves the translocation of FAT/CD36 from
intracellular stores to the sarcolemma, analogous to the regulation of
glucose uptake by GLUT-4.
Acute Regulation of Fatty Acid Uptake Involves the Cellular
Redistribution of Fatty Acid Translocase*
§,¶
,, Department of Kinesiology, University of
Waterloo, Waterloo, Ontario N2L 3G1, Canada, the ¶ Department of
Physiology, Maastricht University, 6200 MD Maastricht, The Netherlands,
and the ** Thrombosis and Vascular Biology Laboratory, Otsuka America
Pharmaceutical, Inc., Rockville, Maryland 20850
*
This work was supported by a grant from the Medical Research
Council of Canada.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Dekker postdoctoral fellow of the Netherlands Heart Foundation.
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