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J Biol Chem, Vol. 275, Issue 19, 14501-14508, May 12, 2000
Acute Regulation of Fatty Acid Uptake Involves the Cellular
Redistribution of Fatty Acid Translocase*
Arend
Bonen §,
Joost J. F. P.
Luiken ¶ ,
Yoga
Arumugam ,
Jan F. C.
Glatz¶, and
Narendra N.
Tandon**
From the Department of Kinesiology, University of
Waterloo, Waterloo, Ontario N2L 3G1, Canada, the ¶ Department of
Physiology, Maastricht University, 6200 MD Maastricht, The Netherlands,
and the ** Thrombosis and Vascular Biology Laboratory, Otsuka America
Pharmaceutical, Inc., Rockville, Maryland 20850
We used muscle contraction, which increases fatty
acid oxidation, as a model to determine whether fatty acid transport is acutely regulated by fatty acid translocase (FAT/CD36). Palmitate uptake by giant vesicles, obtained from skeletal muscle, was increased by muscle contraction. Kinetic studies indicated that muscle
contraction increased Vmax, but
Km remained unaltered.
Sulfo-N-succinimidyl oleate, a specific inhibitor of
FAT/CD36, fully blocked the contraction-induced increase in palmitate
uptake. In giant vesicles from contracting muscles, plasma membrane
FAT/CD36 was also increased in parallel with the increase in long chain
fatty acid uptake. Further studies showed that like GLUT-4, FAT/CD36 is
located in both the plasma membrane and intracellularly (endosomally).
With muscle contraction, FAT/CD36 at the surface of the muscle was
increased, while concomitantly, FAT/CD36 in the intracellular pool was
reduced. Similar responses were observed for GLUT-4. We conclude that
fatty acid uptake is subject to short term regulation by muscle
contraction and involves the translocation of FAT/CD36 from
intracellular stores to the sarcolemma, analogous to the regulation of
glucose uptake by GLUT-4.
*
This work was supported by a grant from the Medical Research
Council of Canada.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
§
To whom correspondence should be addressed. Tel.: 1-519-888-1211 (ext. 5214); Fax: 1-519-746-6776; E-mail:
abonen@healthy.uwaterloo.ca.
Dekker postdoctoral fellow of the Netherlands Heart Foundation.
Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.

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|
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|
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|
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|
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|
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|
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|
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|

|
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|
 |
 
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[Abstract]
[Full Text]
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|
 |
|

|
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|
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[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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[Abstract]
[Full Text]
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|
 |
|

|
 |

|
 |
 
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[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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86(1):
205 - 243.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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January 1, 2006;
100(1):
249 - 257.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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June 1, 2005;
46(6):
1295 - 1302.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Garcia-Martinez, M. Marotta, R. Moore-Carrasco, M. Guitart, M. Camps, S. Busquets, E. Montell, and A. M. Gomez-Foix
Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells
Am J Physiol Cell Physiol,
June 1, 2005;
288(6):
C1264 - C1272.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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Postexercise insulin sensitivity is not impaired after an overnight lipid infusion
Am J Physiol Endocrinol Metab,
March 1, 2005;
288(3):
E519 - E525.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. A. Raney, A. J. Yee, M. K. Todd, and L. P. Turcotte
AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction
Am J Physiol Endocrinol Metab,
March 1, 2005;
288(3):
E592 - E598.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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FAT/CD36-mediated Long-Chain Fatty Acid Uptake in Adipocytes Requires Plasma Membrane Rafts
Mol. Biol. Cell,
January 1, 2005;
16(1):
24 - 31.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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Induction of Adipocyte-Like Phenotype in Human Mesenchymal Stem Cells by Hypoxia
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December 1, 2004;
22(7):
1346 - 1355.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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Exercise rapidly increases expression of the monocarboxylate transporters MCT1 and MCT4 in rat muscle
J. Physiol.,
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561(1):
253 - 261.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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[Abstract]
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|
 |
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|
 |

|
 |
 
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145(10):
4667 - 4676.
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|
 |
|

|
 |

|
 |
 
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Am J Physiol Endocrinol Metab,
October 1, 2004;
287(4):
E696 - E705.
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[Full Text]
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|
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|

|
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|
 |
 
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Am J Physiol Endocrinol Metab,
October 1, 2004;
287(4):
E781 - E789.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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J. Biol. Chem.,
August 27, 2004;
279(35):
36235 - 36241.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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July 1, 2004;
53(7):
1649 - 1654.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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[Full Text]
[PDF]
|
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|

|
 |

|
 |
 
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|
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|
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|
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|
 |
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|
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|
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285(4):
E827 - E835.
[Abstract]
[Full Text]
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P. N. Black and C. C. DiRusso
Transmembrane Movement of Exogenous Long-Chain Fatty Acids: Proteins, Enzymes, and Vectorial Esterification
Microbiol. Mol. Biol. Rev.,
September 1, 2003;
67(3):
454 - 472.
[Abstract]
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B. Binas, X.-X. Han, E. Erol, J. J. F. P. Luiken, J. F. C. Glatz, D. J. Dyck, R. Motazavi, P. J. Adihetty, D. A. Hood, and A. Bonen
A null mutation in H-FABP only partially inhibits skeletal muscle fatty acid metabolism
Am J Physiol Endocrinol Metab,
September 1, 2003;
285(3):
E481 - E489.
[Abstract]
[Full Text]
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Y. Wang, M. Tonouchi, D. Miskovic, H. Hatta, and A. Bonen
T3 increases lactate transport and the expression of MCT4, but not MCT1, in rat skeletal muscle
Am J Physiol Endocrinol Metab,
September 1, 2003;
285(3):
E622 - E628.
[Abstract]
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M. J. Watt, G. R. Steinberg, G. J. F. Heigenhauser, L. L. Spriet, and D. J. Dyck
Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid
Am J Physiol Endocrinol Metab,
August 1, 2003;
285(2):
E412 - E419.
[Abstract]
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J. J.F.P. Luiken, S. L.M. Coort, J. Willems, W. A. Coumans, A. Bonen, G. J. van der Vusse, and J. F.C. Glatz
Contraction-Induced Fatty Acid Translocase/CD36 Translocation in Rat Cardiac Myocytes Is Mediated Through AMP-Activated Protein Kinase Signaling
Diabetes,
July 1, 2003;
52(7):
1627 - 1634.
[Abstract]
[Full Text]
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H. Irie, I. B. Krukenkamp, J. F. F. Brinkmann, G. R. Gaudette, A. E. Saltman, W. Jou, J. F. C. Glatz, N. A. Abumrad, and A. Ibrahimi
Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids
PNAS,
May 27, 2003;
100(11):
6819 - 6824.
[Abstract]
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H. H. A. G. M. van der Putten, E. C. H. Friesema, N. A. Abumrad, M. E. Everts, and T. J. Visser
Thyroid Hormone Transport by the Rat Fatty Acid Translocase
Endocrinology,
April 1, 2003;
144(4):
1315 - 1323.
[Abstract]
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J. J. F. P. Luiken, Y. Arumugam, R. C. Bell, J. Calles-Escandon, N. N. Tandon, J. F. C. Glatz, and A. Bonen
Changes in fatty acid transport and transporters are related to the severity of insulin deficiency
Am J Physiol Endocrinol Metab,
September 1, 2002;
283(3):
E612 - E621.
[Abstract]
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M. Z. Tucker and L. P. Turcotte
Brief food restriction increases FA oxidation and glycogen synthesis under insulin-stimulated conditions
Am J Physiol Regulatory Integrative Comp Physiol,
April 1, 2002;
282(4):
R1210 - R1218.
[Abstract]
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G. R. Steinberg, D. J. Dyck, J. Calles-Escandon, N. N. Tandon, J. J. F. P. Luiken, J. F. C. Glatz, and A. Bonen
Chronic Leptin Administration Decreases Fatty Acid Uptake and Fatty Acid Transporters in Rat Skeletal Muscle
J. Biol. Chem.,
March 8, 2002;
277(11):
8854 - 8860.
[Abstract]
[Full Text]
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J. E. Schaffer
Fatty acid transport: the roads taken
Am J Physiol Endocrinol Metab,
February 1, 2002;
282(2):
E239 - E246.
[Abstract]
[Full Text]
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J. J. F. P. Luiken, D. J. Dyck, X.-X. Han, N. N. Tandon, Y. Arumugam, J. F. C. Glatz, and A. Bonen
Insulin induces the translocation of the fatty acid transporter FAT/CD36 to the plasma membrane
Am J Physiol Endocrinol Metab,
February 1, 2002;
282(2):
E491 - E495.
[Abstract]
[Full Text]
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L. P. Turcotte, J. R. Swenberger, and A. J. Yee
High carbohydrate availability increases LCFA uptake and decreases LCFA oxidation in perfused muscle
Am J Physiol Endocrinol Metab,
January 1, 2002;
282(1):
E177 - E183.
[Abstract]
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J. J. F. P. Luiken, J. Willems, G. J. van der Vusse, and J. F. C. Glatz
Electrostimulation enhances FAT/CD36-mediated long-chain fatty acid uptake by isolated rat cardiac myocytes
Am J Physiol Endocrinol Metab,
October 1, 2001;
281(4):
E704 - E712.
[Abstract]
[Full Text]
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S. E. Campbell, D. J. Angus, and M. A. Febbraio
Glucose kinetics and exercise performance during phases of the menstrual cycle: effect of glucose ingestion
Am J Physiol Endocrinol Metab,
October 1, 2001;
281(4):
E817 - E825.
[Abstract]
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L. J C van Loon, P. L Greenhaff, D Constantin-Teodosiu, W. H M Saris, and A. J M Wagenmakers
The effects of increasing exercise intensity on muscle fuel utilisation in humans
J. Physiol.,
October 1, 2001;
536(1):
295 - 304.
[Abstract]
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D. J. Dyck, G. Steinberg, and A. Bonen
Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle
Am J Physiol Endocrinol Metab,
September 1, 2001;
281(3):
E600 - E607.
[Abstract]
[Full Text]
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J. J. F. P. Luiken, Y. Arumugam, D. J. Dyck, R. C. Bell, M. M. L. Pelsers, L. P. Turcotte, N. N. Tandon, J. F. C. Glatz, and A. Bonen
Increased Rates of Fatty Acid Uptake and Plasmalemmal Fatty Acid Transporters in Obese Zucker Rats
J. Biol. Chem.,
October 26, 2001;
276(44):
40567 - 40573.
[Abstract]
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G. R. Steinberg, A. Bonen, and D. J. Dyck
Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats
Am J Physiol Endocrinol Metab,
March 1, 2002;
282(3):
E593 - E600.
[Abstract]
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M. Tonouchi, H. Hatta, and A. Bonen
Muscle contraction increases lactate transport while reducing sarcolemmal MCT4, but not MCT1
Am J Physiol Endocrinol Metab,
May 1, 2002;
282(5):
E1062 - E1069.
[Abstract]
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Copyright © 2000 by the American Society for Biochemistry and Molecular Biology.
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