| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 275, Issue 19, 14598-14607, May 12, 2000
From the Department of Research Administration, Immunex
Corporation, Seattle, Washington 98101
The extracellular domains of many proteins,
including growth factors, cytokines, receptors, and adhesion molecules,
are proteolytically released from cells, a process termed
"shedding." Tumor necrosis factor-
Stimulation-induced Down-regulation of Tumor Necrosis Factor-
Converting Enzyme*
and
converting enzyme
(TACE/ADAM-17) is a metalloprotease-disintegrin that sheds tumor
necrosis factor- and other proteins. To study the regulation of
TACE-mediated shedding, we examined the effects of stimulation of cells
on TACE localization and expression. Immunofluorescence microscopy
revealed a punctate distribution of TACE on the surface of untreated
cells, and stimulation of monocytic cells with lipopolysaccharide did
not affect TACE staining. Phorbol 12-myristate 13-acetate (PMA), a
potent inducer of shedding, decreased cell-surface staining for TACE.
Surface biotinylation experiments confirmed and extended this
observation; PMA decreased the half-life of surface-biotinylated TACE
without increasing the turnover of total cell-surface proteins. Soluble
fragments of TACE were not detected in the medium of cells that had
down-regulated TACE, and TACE was not down-regulated when endocytosis
was inhibited. Antibody uptake experiments suggested that cell-surface
TACE was internalized in response to PMA. Surprisingly, a
metalloprotease inhibitor prevented the PMA-induced turnover of TACE.
Thus, PMA activates shedding and causes the down-regulation of a major
"sheddase," suggesting that induced shedding may be regulated by a
mechanism that decreases the amount of active TACE on the cell surface.
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed: Immunex Corp., 51 University St., Seattle, WA 98101. Tel.: 206-587-0430; Fax: 206-621-7977; E-mail: doedensj@immunex.com.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. J. Levine Molecular Mechanisms of Soluble Cytokine Receptor Generation J. Biol. Chem., May 23, 2008; 283(21): 14177 - 14181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Schaff, P. E. Mattila, S. I. Simon, and B. Walcheck Neutrophil adhesion to E-selectin under shear promotes the redistribution and co-clustering of ADAM17 and its proteolytic substrate L-selectin J. Leukoc. Biol., January 1, 2008; 83(1): 99 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gomez-Gaviro, M. Dominguez-Luis, J. Canchado, J. Calafat, H. Janssen, E. Lara-Pezzi, A. Fourie, A. Tugores, A. Valenzuela-Fernandez, F. Mollinedo, et al. Expression and Regulation of the Metalloproteinase ADAM-8 during Human Neutrophil Pathophysiological Activation and Its Catalytic Activity on L-Selectin Shedding J. Immunol., June 15, 2007; 178(12): 8053 - 8063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Santiago-Josefat, C. Esselens, J. J. Bech-Serra, and J. Arribas Post-transcriptional Up-regulation of ADAM17 upon Epidermal Growth Factor Receptor Activation and in Breast Tumors J. Biol. Chem., March 16, 2007; 282(11): 8325 - 8331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Horiuchi, S. Le Gall, M. Schulte, T. Yamaguchi, K. Reiss, G. Murphy, Y. Toyama, D. Hartmann, P. Saftig, and C. P. Blobel Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx Mol. Biol. Cell, January 1, 2007; 18(1): 176 - 188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Nishi, Y. Hiraoka, K. Yoshida, K. Okawa, and T. Kita Nardilysin Enhances Ectodomain Shedding of Heparin-binding Epidermal Growth Factor-like Growth Factor through Activation of Tumor Necrosis Factor-{alpha}-converting Enzyme J. Biol. Chem., October 13, 2006; 281(41): 31164 - 31172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Loesch, L. Deng, J. W. Cowan, X. Wang, K. He, J. Jiang, R. A. Black, and S. J. Frank Janus Kinase 2 Influences Growth Hormone Receptor Metalloproteolysis Endocrinology, June 1, 2006; 147(6): 2839 - 2849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. X. G. Shao and J. A. Nadel Neutrophil Elastase Induces MUC5AC Mucin Production in Human Airway Epithelial Cells via a Cascade Involving Protein Kinase C, Reactive Oxygen Species, and TNF-{alpha}-Converting Enzyme J. Immunol., September 15, 2005; 175(6): 4009 - 4016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Gomez, S. H. Sokol, A. B. Muir, G. Soong, J. Bastien, and A. S. Prince Bacterial Induction of TNF-{alpha} Converting Enzyme Expression and IL-6 Receptor {alpha} Shedding Regulates Airway Inflammatory Signaling J. Immunol., August 1, 2005; 175(3): 1930 - 1936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Soond, B. Everson, D. W. H. Riches, and G. Murphy ERK-mediated phosphorylation of Thr735 in TNF{alpha}-converting enzyme and its potential role in TACE protein trafficking J. Cell Sci., June 1, 2005; 118(11): 2371 - 2380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Buckley, F. N. Rouhani, M. Kaler, B. Adamik, F. I. Hawari, and S. J. Levine Amino-terminal TACE prodomain attenuates TNFR2 cleavage independently of the cysteine switch Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1132 - L1138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Peiretti, M. Canault, D. Bernot, B. Bonardo, P. Deprez-Beauclair, I. Juhan-Vague, and G. Nalbone Proteasome inhibition activates the transport and the ectodomain shedding of TNF-{alpha} receptors in human endothelial cells J. Cell Sci., March 1, 2005; 118(5): 1061 - 1070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Robertshaw and F. M. Brennan Release of tumour necrosis factor {alpha} (TNF{alpha}) by TNF{alpha} cleaving enzyme (TACE) in response to septic stimuli in vitro Br. J. Anaesth., February 1, 2005; 94(2): 222 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Adair-Kirk, J. J. Atkinson, D. G. Kelley, R. H. Arch, J. H. Miner, and R. M. Senior A Chemotactic Peptide from Laminin {alpha}5 Functions as a Regulator of Inflammatory Immune Responses via TNF{alpha}-mediated Signaling J. Immunol., February 1, 2005; 174(3): 1621 - 1629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. X. G. Shao and J. A. Nadel Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells PNAS, January 18, 2005; 102(3): 767 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Levine Mechanisms of Soluble Cytokine Receptor Generation J. Immunol., November 1, 2004; 173(9): 5343 - 5348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ivetic, O. Florey, J. Deka, D. O. Haskard, A. Ager, and A. J. Ridley Mutagenesis of the Ezrin-Radixin-Moesin Binding Domain of L-selectin Tail Affects Shedding, Microvillar Positioning, and Leukocyte Tethering J. Biol. Chem., August 6, 2004; 279(32): 33263 - 33272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. V. Bax, A. J. Messent, J. Tart, M. van Hoang, J. Kott, R. A. Maciewicz, and M. J. Humphries Integrin {alpha}5{beta}1 and ADAM-17 Interact in Vitro and Co-localize in Migrating HeLa Cells J. Biol. Chem., May 21, 2004; 279(21): 22377 - 22386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang, G. Z. Feuerstein, L. Xu, H. Wang, W. A. Schumacher, M. L. Ogletree, R. Taub, J. J.-W. Duan, C. P. Decicco, and R.-Q. Liu Inhibition of Tumor Necrosis Factor-{alpha}-Converting Enzyme by a Selective Antagonist Protects Brain from Focal Ischemic Injury in Rats Mol. Pharmacol., April 1, 2004; 65(4): 890 - 896. [Abstract] [Full Text]
|
|
|
|
|
|
J. R. Worley, M. D. Baugh, D. A. Hughes, D. R. Edwards, A. Hogan, M. J. Sampson, and J. Gavrilovic Metalloproteinase Expression in PMA-stimulated THP-1 Cells: EFFECTS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-{gamma} (PPAR{gamma}) AGONISTS AND 9-CIS-RETINOIC ACID J. Biol. Chem., December 19, 2003; 278(51): 51340 - 51346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Matthews, B. Schuster, S. Schutze, I. Bussmeyer, A. Ludwig, C. Hundhausen, T. Sadowski, P. Saftig, D. Hartmann, K.-J. Kallen, et al. Cellular Cholesterol Depletion Triggers Shedding of the Human Interleukin-6 Receptor by ADAM10 and ADAM17 (TACE) J. Biol. Chem., October 3, 2003; 278(40): 38829 - 38839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Wheeler, K. J. Ness, T. D. Oberley, and A. K. Verma Protein Kinase C{epsilon} Is Linked to 12-O-tetradecanoylphorbol-13-acetate-induced Tumor Necrosis Factor-{alpha} Ectodomain Shedding and the Development of Metastatic Squamous Cell Carcinoma in Protein Kinase C{epsilon} Transgenic Mice Cancer Res., October 1, 2003; 63(19): 6547 - 6555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Smith, V. Patel, S. D. Seatter, M. R. Deehan, M. H. Brown, G. P. Brooke, H. S. Goodridge, C. J. Howard, K. P. Rigley, W. Harnett, et al. A novel MyD-1 (SIRP-1{alpha}) signaling pathway that inhibits LPS-induced TNF{alpha} production by monocytes Blood, October 1, 2003; 102(7): 2532 - 2540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. X. G. Shao, I. F. Ueki, and J. A. Nadel Tumor necrosis factor {alpha}-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells PNAS, September 30, 2003; 100(20): 11618 - 11623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Contin, V. Pitard, T. Itai, S. Nagata, J.-F. Moreau, and J. Dechanet-Merville Membrane-anchored CD40 Is Processed by the Tumor Necrosis Factor-{alpha}-converting Enzyme: IMPLICATIONS FOR CD40 SIGNALING J. Biol. Chem., August 29, 2003; 278(35): 32801 - 32809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, R. S. Al-Lamki, H. Zhang, N. Kirkiles-Smith, M. L. Gaeta, S. Thiru, J. S. Pober, and J. R. Bradley Histamine Antagonizes Tumor Necrosis Factor (TNF) Signaling by Stimulating TNF Receptor Shedding from the Cell Surface and Golgi Storage Pool J. Biol. Chem., June 6, 2003; 278(24): 21751 - 21760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Pedron, R. Girard, and R. Chaby TLR4-dependent Lipopolysaccharide-induced Shedding of Tumor Necrosis Factor Receptors in Mouse Bone Marrow Granulocytes J. Biol. Chem., May 30, 2003; 278(23): 20555 - 20564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Peiretti, P. Deprez-Beauclair, B. Bonardo, H. Aubert, I. Juhan-Vague, and G. Nalbone Identification of SAP97 as an intracellular binding partner of TACE J. Cell Sci., May 15, 2003; 116(10): 1949 - 1957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pribyl, C. B. Muratov, and S. Y. Shvartsman Long-Range Signal Transmission in Autocrine Relays Biophys. J., February 1, 2003; 84(2): 883 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Thathiah, C. P. Blobel, and D. D. Carson Tumor Necrosis Factor-alpha Converting Enzyme/ADAM 17 Mediates MUC1 Shedding J. Biol. Chem., January 24, 2003; 278(5): 3386 - 3394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zheng, J. Schlondorff, and C. P. Blobel Evidence for Regulation of the Tumor Necrosis Factor alpha -Convertase (TACE) by Protein-tyrosine Phosphatase PTPH1 J. Biol. Chem., November 1, 2002; 277(45): 42463 - 42470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Brynskov, P Foegh, G Pedersen, C Ellervik, T Kirkegaard, A Bingham, and T Saermark Tumour necrosis factor {alpha} converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease Gut, July 1, 2002; 51(1): 37 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cartee, R. Smith, Y. Dai, M. Rahmani, R. Rosato, J. Almenara, P. Dent, and S. Grant Synergistic Induction of Apoptosis in Human Myeloid Leukemia Cells by Phorbol 12-Myristate 13-Acetate and Flavopiridol Proceeds via Activation of Both the Intrinsic and Tumor Necrosis Factor-Mediated Extrinsic Cell Death Pathways Mol. Pharmacol., June 1, 2002; 61(6): 1313 - 1321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Diaz-Rodriguez, J. C. Montero, A. Esparis-Ogando, L. Yuste, and A. Pandiella Extracellular Signal-regulated Kinase Phosphorylates Tumor Necrosis Factor alpha -converting Enzyme at Threonine 735: A Potential Role in Regulated Shedding Mol. Biol. Cell, June 1, 2002; 13(6): 2031 - 2044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Sunnarborg, C. L. Hinkle, M. Stevenson, W. E. Russell, C. S. Raska, J. J. Peschon, B. J. Castner, M. J. Gerhart, R. J. Paxton, R. A. Black, et al. Tumor Necrosis Factor-alpha Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability J. Biol. Chem., April 5, 2002; 277(15): 12838 - 12845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jiang, K. Lehti, X. Wang, S. J. Weiss, J. Keski-Oja, and D. Pei Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis PNAS, October 31, 2001; (2001) 241293698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Fors, K. Goodarzi, and U. H. von Andrian L-Selectin Shedding Is Independent of Its Subsurface Structures and Topographic Distribution J. Immunol., October 1, 2001; 167(7): 3642 - 3651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jiang, K. Lehti, X. Wang, S. J. Weiss, J. Keski-Oja, and D. Pei Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis PNAS, November 20, 2001; 98(24): 13693 - 13698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Shvartsman, M. P. Hagan, A. Yacoub, P. Dent, H. S. Wiley, and D. A. Lauffenburger Autocrine loops with positive feedback enable context-dependent cell signaling Am J Physiol Cell Physiol, March 1, 2002; 282(3): C545 - C559. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
